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Crystal structures can be predicted from first-principles using ab initio random structure searching AIRSS and density functional theory (DFT). AIRSS provides a method to sample the potential energy landscape and DFT provides a robust and…

Materials Science · Physics 2025-09-30 Lewis J. Conway , Chris J. Pickard

In materials discovery, the integration of first-principles calculations with machine learning techniques has been actively studied for two key tasks: crystal structure prediction, which searches for stable structures given a chemical…

Materials Science · Physics 2026-04-14 Akira Kusaba , Tetsuji Kuboyama , Karol Kawka , Pawel Kempisty , Yoshihiro Kangawa

Efficiently and accurately determining the symmetry is a crucial step in the structural analysis of crystalline materials. Existing methods usually mindlessly apply deep learning models while ignoring the underlying chemical rules. More…

Machine Learning · Computer Science 2025-11-11 Liheng Yu , Zhe Zhao , Xucong Wang , Di Wu , Pengkun Wang

Causal structure discovery from observational data is fundamental to the causal understanding of autonomous systems such as medical decision support systems, advertising campaigns and self-driving cars. This is essential to solve well-known…

As computers get faster, researchers -- not hardware or algorithms -- become the bottleneck in scientific discovery. Computational study of colloidal self-assembly is one area that is keenly affected: even after computers generate massive…

Soft Condensed Matter · Physics 2018-03-28 Matthew Spellings , Sharon C Glotzer

Efficient structure search is a major challenge in computational materials science. We present a modification of the basin hopping global geometry optimization approach that uses a curvilinear coordinate system to describe global trial…

The emergence of deep learning has brought the long-standing goal of comprehensively understanding and exploring crystalline materials closer to reality. Yet, universal exploration across all elements remains hindered by the combinatorial…

Materials Science · Physics 2025-11-18 Fengyu Xie , Ruoyu Wang , Taoyuze Lv , Yuxiang Gao , Hongyu Wu , Zhicheng Zhong

Protein structure prediction can be shown to be an NP-hard problem; the number of conformations grows exponentially with the number of residues. The native conformations of proteins occupy a very small subset of these, hence an exploratory,…

Chemical Physics · Physics 2008-02-03 Mehul M. Khimasia , Peter V. Coveney

Structural search and feature extraction are a central subject in modern materials design, the efficiency of which is currently limited, but can be potentially boosted by machine learning (ML). Here, we develop an ML-based…

Materials Science · Physics 2023-02-08 Chuannan Li , Hanpu Liang , Xie Zhang , Zijing Lin , Su-Huai Wei

Accurately determining the crystallographic structure of a material, organic or inorganic, is a critical primary step in material development and analysis. The most common practices involve analysis of diffraction patterns produced in…

Solving black-box optimization problems with Ising machines is increasingly common in materials science. However, their application to crystal structure prediction (CSP) is still ineffective due to symmetry agnostic encoding of atomic…

Materials Science · Physics 2025-04-10 Chen Liang , Diptesh Das , Jiang Guo , Ryo Tamura , Zetian Mao , Koji Tsuda

The design of crystal materials plays a critical role in areas such as new energy development, biomedical engineering, and semiconductors. Recent advances in data-driven methods have enabled the generation of diverse crystal structures.…

Artificial Intelligence · Computer Science 2025-12-12 Chao Huang , Jiahui Chen , Chen Chen , Chen Chen , Chunyan Chen , Renjie Su , Shiyu Du

Predicting properties of crystals from their structures is a fundamental yet challenging task in materials science. Unlike molecules, crystal structures exhibit infinite periodic arrangements of atoms, requiring methods capable of capturing…

Machine Learning · Computer Science 2025-09-29 Jianan Nie , Peiyao Xiao , Kaiyi Ji , Peng Gao

Owing to the advances in computational techniques and the increase in computational power, atomistic simulations of materials can simulate large systems with higher accuracy. Complex phenomena can be observed in such state-of-the-art…

Materials Science · Physics 2022-02-16 Ryo Tamura , Momo Matsuda , Jianbo Lin , Yasunori Futamura , Tetsuya Sakurai , Tsuyoshi Miyazaki

Digital reticular chemistry relies on accurate crystal structures to power computational screening, data-driven discovery, and structure-property analysis, yet recent studies reveal that more than half of the top-performing candidates in…

Materials Science · Physics 2026-04-23 Yongchul G. Chung , Myoung Soo Lah

In this paper, we study the construction of structural models for the description of substitutional defects in crystalline materials. Predicting and designing the atomic structures in such systems is highly challenging due to the…

Computational Physics · Physics 2025-07-04 Xiaoxu Li , Ge Xu , Huajie Chen , Xingyu Gao , Haifeng Song

The arrival of AI techniques in computations, with the potential for hallucinations and non-robustness, has made trustworthiness of algorithms a focal point. However, trustworthiness of the many classical approaches are not well understood.…

Optimization and Control · Mathematics 2023-12-19 Alexander Bastounis , Felipe Cucker , Anders C. Hansen

Many proteins carry out their biological functions by forming the characteristic tertiary structures. Therefore, the search of the stable states of proteins by molecular simulations is important to understand their functions and…

Biomolecules · Quantitative Biology 2015-05-22 Yoshitake Sakae , Tomoyuki Hiroyasu , Mitsunori Miki , Katsuya Ishii , Yuko Okamoto

While topological materials are not restricted to crystals, there is no efficient method to diagnose topology in non-crystalline solids such as amorphous materials. Here we introduce the structural spillage, a new indicator that predicts…

Mesoscale and Nanoscale Physics · Physics 2023-10-13 Daniel Muñoz-Segovia , Paul Corbae , Dániel Varjas , Frances Hellman , Sinéad M. Griffin , Adolfo G. Grushin

Structured prediction tasks pose a fundamental trade-off between the need for model complexity to increase predictive power and the limited computational resources for inference in the exponentially-sized output spaces such models require.…

Machine Learning · Statistics 2012-08-17 David Weiss , Benjamin Sapp , Ben Taskar