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Modern electron tomography has progressed to higher resolution at lower doses by leveraging compressed sensing methods that minimize total variation (TV). However, these sparsity-emphasized reconstruction algorithms introduce tunable…

Medical Physics · Physics 2023-09-12 William Millsaps , Jonathan Schwartz , Zichao Wendy Di , Yi Jiang , Robert Hovden

Direct observation of nanoscale transformations in three dimensions (3D) is essential for understanding materials evolution under operating conditions, yet dynamic electron tomography remains limited by slow tilt series acquisition and by…

Three-dimensional electron diffraction (3D ED) has emerged as a powerful method for solving the structures of sub-micron-sized particles down to nanoparticles. However, it faces technical challenges when applied to beam-sensitive samples or…

Electrical Impedance Tomography (EIT) is a powerful tool for non-destructive evaluation, state estimation, and process tomography - among numerous other use cases. For these applications, and in order to reliably reconstruct images of a…

Signal Processing · Electrical Eng. & Systems 2020-01-31 Danny Smyl , Dong Liu

Cryogenic electron tomography is a technique for imaging biological samples in 3D. A microscope collects a series of 2D projections of the sample, and the goal is to reconstruct the 3D density of the sample called the tomogram.…

Computer Vision and Pattern Recognition · Computer Science 2024-08-13 Simon Wiedemann , Reinhard Heckel

Transmission electron microscopes use electrons with wavelengths of a few picometers, potentially capable of imaging individual atoms in solids at a resolution ultimately set by the intrinsic size of an atom. Unfortunately, due to…

Size effects are ubiquitous in the structural, mechanical, and physical properties of materials, making it highly desirable to study the intrinsic properties of thick objects through high-resolution structural analysis in transmission…

Materials Science · Physics 2025-02-26 Wenfeng Yang , Haozhi Sha , Jizhe Cui , Rong Yu

Atomic resolution imaging in transmission electron microscopy (TEM) and scanning TEM (STEM) of light elements in electron-transparent materials has long been a challenge. Biomolecular materials, for example, are rapidly altered when…

Instrumentation and Detectors · Physics 2018-12-05 Fehmi S. Yasin , Tyler R. Harvey , Jordan J. Chess , Jordan S. Pierce , Colin Ophus , Peter Ercius , Benjamin J. McMorran

Real-space imaging of three-dimensional atomic structures is a critical yet challenging task in materials science. Although scanning transmission electron microscopy has achieved sub-angstrom lateral resolution through techniques like…

Electron tomography is a widely used technique for 3D structural analysis of nanomaterials, but it can cause damage to samples due to high electron doses and long exposure times. To minimize such damage, researchers often reduce beam…

Image and Video Processing · Electrical Eng. & Systems 2023-04-05 Timothy M. Craig , Ajinkya A Kadu , Kees Joost Batenburg , Sara Bals

Transmission electron microscopy (TEM) is a potent technique for the determination of three-dimensional atomic scale structure of samples in structural biology and materials science. In structural biology, three-dimensional structures of…

Electron ptychography describes a family of algorithms which are used to enable the reconstruction of complex specimen transmission functions of a sample in order to obtain both phase and amplitude information, as applied within the realms…

Optics · Physics 2025-03-17 L. Clark , P. D. Nellist

In a comprehensive study on several samples we demonstrate for our laboratory-based computed tomography system resolutions down to 150nm. The achieved resolution is validated by imaging com-mon test structures in 2D and Fourier Shell…

Instrumentation and Detectors · Physics 2021-02-15 Dominik Müller , Jonas Graetz , Andreas Balles , Simon Stier , Randolf Hanke , Christian Fella

Electron tomography has become a commonly used tool to investigate the three-dimensional (3D) structure of nanomaterials, including colloidal nanoparticle assemblies. However, electron microscopy is typically carried out under high vacuum…

To date, high-resolution (< 1 nm) imaging of extended objects in three-dimensions (3D) has not been possible. A restriction known as the Crowther criterion forces a tradeoff between object size and resolution for 3D reconstructions by…

Materials Science · Physics 2014-11-20 Robert Hovden , Peter Ercius , Yi Jiang , Deli Wang , Yingchao Yu , Hector D. Abruna , Veit Elser , David A. Muller

Electron tomography (ET) plays an important role in the three-dimensional (3D) characterization of nanomaterials. However, under limited-angle and sparse-view conditions, conventional algorithms produce degraded reconstructions, which…

Image and Video Processing · Electrical Eng. & Systems 2026-05-27 Serge Brosset , Daniel del Pozo Bueno , Thomas David , Laure Guetaz , Philippe Ciuciu , Zineb Saghi

Proton radiography is a technique extensively used to resolve magnetic field structures in high energy density plasmas, revealing a whole variety of interesting phenomena such as magnetic reconnection and collisionless shocks found in…

Limited-angle electron tomography aims to reconstruct 3D shapes from 2D projections of Transmission Electron Microscopy (TEM) within a restricted range and number of tilting angles, but it suffers from the missing-wedge problem that causes…

Computer Vision and Pattern Recognition · Computer Science 2026-05-05 Zhantao Deng , Mériem Er-Rafik , Anna Sushko , Cécile Hébert , Pascal Fua

The most sophisticated existing methods to generate 3D isotropic super-resolution (SR) from non-isotropic electron microscopy (EM) are based on learned dictionaries. Unfortunately, none of the existing methods generate practically…

Computer Vision and Pattern Recognition · Computer Science 2017-06-13 Larissa Heinrich , John A. Bogovic , Stephan Saalfeld

In tomographic reconstruction, the image quality of the reconstructed images can be significantly degraded by defects in the measured two-dimensional (2D) raw image data. Despite the importance of screening defective 2D images for robust…

Image and Video Processing · Electrical Eng. & Systems 2019-10-29 Donghun Ryu , Youngju Jo , Jihyeong Yoo , Taean Chang , Daewoong Ahn , Young Seo Kim , Geon Kim , Hyun-seok Min , Yongkeun Park