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Deep learning models are routinely employed in computational pathology (CPath) for solving problems of diagnostic and prognostic significance. Typically, the generalization performance of CPath models is analyzed using evaluation protocols…

Image and Video Processing · Electrical Eng. & Systems 2021-06-18 Alex Foote , Amina Asif , Ayesha Azam , Tim Marshall-Cox , Nasir Rajpoot , Fayyaz Minhas

Nuclei segmentation is one of the important tasks for whole slide image analysis in digital pathology. With the drastic advance of deep learning, recent deep networks have demonstrated successful performance of the nuclei segmentation task.…

Computer Vision and Pattern Recognition · Computer Science 2019-07-23 Inwan Yoo , Donggeun Yoo , Kyunghyun Paeng

Leukemia is the 10th most frequently diagnosed cancer and one of the leading causes of cancer-related deaths worldwide. Realistic analysis of leukemia requires white blood cell (WBC) localization, classification, and morphological…

Computer Vision and Pattern Recognition · Computer Science 2025-08-12 Abdul Rehman , Talha Meraj , Aiman Mahmood Minhas , Ayisha Imran , Mohsen Ali , Waqas Sultani , Mubarak Shah

Advances in digitizing tissue slides and the fast-paced progress in artificial intelligence, including deep learning, have boosted the field of computational pathology. This field holds tremendous potential to automate clinical diagnosis,…

Image and Video Processing · Electrical Eng. & Systems 2024-01-17 Andrew H. Song , Guillaume Jaume , Drew F. K. Williamson , Ming Y. Lu , Anurag Vaidya , Tiffany R. Miller , Faisal Mahmood

For diagnosing melanoma, hematoxylin and eosin (H&E) stained tissue slides remains the gold standard. These images contain quantitative information in different magnifications. In the present study, we investigated whether deep…

Tissues and Organs · Quantitative Biology 2019-04-15 Peizhen Xie , Ke Zuo , Yu Zhang , Fangfang Li , Mingzhu Yin , Kai Lu

Over half a million individuals are diagnosed with head and neck cancer each year worldwide. Radiotherapy is an important curative treatment for this disease, but it requires manual time consuming delineation of radio-sensitive organs at…

Breast cancer is a highly heterogeneous disease with diverse molecular profiles. The PAM50 gene signature is widely recognized as a standard for classifying breast cancer into intrinsic subtypes, enabling more personalized treatment…

Feature vectors provided by pre-trained deep artificial neural networks have become a dominant source for image representation in recent literature. Their contribution to the performance of image analysis can be improved through finetuning.…

Multi-class tissue-type classification of colorectal cancer (CRC) histopathologic images is a significant step in the development of downstream machine learning models for diagnosis and treatment planning. However, existing public CRC…

Computational Engineering, Finance, and Science · Computer Science 2025-11-10 Barathi Subramanian , Rathinaraja Jeyaraj , Mitchell Nevin Peterson , Terry Guo , Nigam Shah , Curtis Langlotz , Andrew Y. Ng , Jeanne Shen

Instance segmentation and classification of nuclei is an important task in computational pathology. We show that StarDist, a deep learning nuclei segmentation method originally developed for fluorescence microscopy, can be extended and…

Computer Vision and Pattern Recognition · Computer Science 2022-08-22 Martin Weigert , Uwe Schmidt

Recent studies have shown promising results in using Deep Learning to detect malignancy in whole slide imaging. However, they were limited to just predicting positive or negative finding for a specific neoplasm. We attempted to use Deep…

Computer Vision and Pattern Recognition · Computer Science 2018-11-08 Hanadi El Achi , Tatiana Belousova , Lei Chen , Amer Wahed , Iris Wang , Zhihong Hu , Zeyad Kanaan , Adan Rios , Andy N. D. Nguyen

Diagnosing and treating skin diseases require advanced visual skills across domains and the ability to synthesize information from multiple imaging modalities. While current deep learning models excel at specific tasks like skin cancer…

Computational cytology is a critical, rapid-developing, yet challenging topic in the field of medical image computing which analyzes the digitized cytology image by computer-aided technologies for cancer screening. Recently, an increasing…

Image and Video Processing · Electrical Eng. & Systems 2023-03-21 Hao Jiang , Yanning Zhou , Yi Lin , Ronald CK Chan , Jiang Liu , Hao Chen

Prognostic information at diagnosis has important implications for cancer treatment and monitoring. Although cancer staging, histopathological assessment, molecular features, and clinical variables can provide useful prognostic insights,…

Obtaining semantic labels on a large scale radiology image database (215,786 key images from 61,845 unique patients) is a prerequisite yet bottleneck to train highly effective deep convolutional neural network (CNN) models for image…

Computer Vision and Pattern Recognition · Computer Science 2016-03-28 Xiaosong Wang , Le Lu , Hoo-chang Shin , Lauren Kim , Isabella Nogues , Jianhua Yao , Ronald Summers

Due to the recent advancements in machine vision, digital pathology has gained significant attention. Histopathology images are distinctly rich in visual information. The tissue glass slide images are utilized for disease diagnosis.…

Image and Video Processing · Electrical Eng. & Systems 2020-11-02 Danial Maleki , Mehdi Afshari , Morteza Babaie , H. R. Tizhoosh

Prognostic task is of great importance as it closely related to the survival analysis of patients, the optimization of treatment plans and the allocation of resources. The existing prognostic models have shown promising results on specific…

Image and Video Processing · Electrical Eng. & Systems 2025-01-14 Binyu Zhang , Shichao Li , Junpeng Jian , Zhu Meng , Limei Guo , Zhicheng Zhao

Treatment approaches for colorectal cancer (CRC) are highly dependent on the molecular subtype, as immunotherapy has shown efficacy in cases with microsatellite instability (MSI) but is ineffective for the microsatellite stable (MSS)…

Computer Vision and Pattern Recognition · Computer Science 2024-11-13 Hadar Hezi , Matan Gelber , Alexander Balabanov , Yosef E. Maruvka , Moti Freiman

Nasopharyngeal carcinoma (NPC) is one of the understudied yet deadliest cancers in South East Asia. In Malaysia, the prevalence is identified mainly in Sarawak, among the ethnic of Bidayuh. NPC is often late-diagnosed because it is…

Image and Video Processing · Electrical Eng. & Systems 2024-04-05 W. S. H. M. W. Ahmad , M. F. A. Fauzi , M. K. Abdullahi , Jenny T. H. Lee , N. S. A. Basry , A Yahaya , A. M. Ismail , A. Adam , Elaine W. L. Chan , F. S. Abas

Accurately and quickly binuclear cell (BC) detection plays a significant role in predicting the risk of leukemia and other malignant tumors. However, manual microscopy counting is time-consuming and lacks objectivity. Moreover, with the…

Computer Vision and Pattern Recognition · Computer Science 2022-08-29 Baomin Wang , Geng Hu , Dan Chen , Lihua Hu , Cheng Li , Yu An , Guiping Hu , Guang Jia