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Cells or bacteria carrying cilia on their surface show many striking features : alignment of cilia in an array, two-phase asymmetric beating for each cilium, coordination between cilia and existence of metachronal waves with a constant…

Biological Physics · Physics 2009-11-11 Boris Guirao , Jean-François Joanny

Motile cilia beat in an asymmetric fashion in order to propel the surrounding fluid. When many cilia are located on a surface, their beating can synchronise such that their phases form metachronal waves. Here, we computationally study a…

Soft Condensed Matter · Physics 2023-09-29 David J. Hickey , Ramin Golestanian , Andrej Vilfan

Synchronisation is often observed in the swimming of flagellated cells, either for multiple appendages on the same organism or between the flagella of nearby cells. Beating cilia are also seen to synchronise their dynamics. In 1951, Taylor…

Biological Physics · Physics 2021-04-28 Weida Liao , Eric Lauga

We calculate the hydrodynamic flow field generated far from a cilium which is attached to a surface and beats periodically. In the case of two beating cilia, hydrodynamic interactions can lead to synchronization of the cilia, which are…

Biological Physics · Physics 2007-05-23 Andrej Vilfan , Frank Julicher

A model of coupled molecular oscillators is proposed to study nonequilibrium thermodynamics of synchronization. We find that synchronization of nonequilibrium oscillators costs energy even when the oscillator-oscillator coupling is…

Biological Physics · Physics 2020-01-29 Dongliang Zhang , Yuansheng Cao , Qi Ouyang , Yuhai Tu

Direct mechanical coupling is known to be critical for establishing synchronization among cilia. However, the actual role of the connections is still elusive - partly because controlled experiments in live samples are challenging. Here, we…

Soft Condensed Matter · Physics 2023-12-27 Yiming Xia , Zixian Hu , Da Wei , Ke Chen , Yi Peng , Mingcheng Yang

We introduce a measure for energetic efficiency of biological cilia acting individually or collectively and numerically determine the optimal beating patterns according to this criterion. Maximizing the efficiency of a single cilium leads…

Biological Physics · Physics 2011-09-21 Natan Osterman , Andrej Vilfan

Carpets of actively bending cilia represent arrays of biological oscillators that can exhibit self-organized metachronal synchronization in the form of traveling waves of cilia phase. This metachronal coordination supposedly enhances fluid…

Biological Physics · Physics 2022-01-11 Anton Solovev , Benjamin M. Friedrich

Recent exploration of collective phenomena in oscillator arrays has highlighted its potential for accessing a range of physical phenomena, from fundamental quantum many-body dynamics to the solution of practical optimization problems using…

Carpets of beating cilia represent a paradigmatic example of self-organized synchronization of noisy biological oscillators, characterized by traveling waves of cilia phase. We present a multi-scale model of a cilia carpet, which comprises…

Biological Physics · Physics 2022-03-17 Anton Solovev , Benjamin M. Friedrich

Synchronization plays a crucial role in the dynamics of living organisms, from fireflies flashing in unison to pacemaker cells that jointly generate heartbeats. Uncovering the mechanism behind these phenomena requires an understanding of…

Adaptation and Self-Organizing Systems · Physics 2024-05-16 Aleksandre Japaridze , Victor Struijk , Kushal Swamy , Irek Roslon , Oriel Shoshani , Cees Dekker , Farbod Alijani

We study the dynamics of phase synchronization in growing populations of discrete phase oscillatory systems when the division process is coupled to the distribution of oscillator phases. Using mean field theory, linear stability analysis,…

Statistical Mechanics · Physics 2015-06-16 Wen Yu , Kevin B. Wood

On surfaces with many motile cilia, beats of the individual cilia coordinate to form metachronal waves. We present a theoretical framework that connects the dynamics of an individual cilium to the collective dynamics of a ciliary carpet via…

Soft Condensed Matter · Physics 2021-03-12 Fanlong Meng , Rachel R. Bennett , Nariya Uchida , Ramin Golestanian

Ciliated tissues such as in the mammalian lungs, brains, and reproductive tracts, are specialized to pump fluid. They generate flows by the collective activity of hundreds of thousands of individual cilia that beat in a striking metachronal…

Soft Condensed Matter · Physics 2022-11-30 Anup Kanale , Feng Ling , Hanliang Guo , Sebastian Fuerthauer , Eva Kanso

Cellular appendages conferring motility, such as flagella or cilia, are known to synchronise their periodic beats. The origin of synchronisation is a combination of long-range hydrodynamic interactions with physical mechanisms allowing the…

Biological Physics · Physics 2021-04-21 Ivan Tanasijević , Eric Lauga

To gain insight into the nature of biological synchronization at the microscopic scale, we here investigate the hydrodynamic synchronization between conically rotating objects termed nodal cilia. A mechanical model of three rotating cilia…

Soft Condensed Matter · Physics 2018-03-28 Keiji Okumura , Seiya Nishikawa , Toshihiro Omori , Takuji Ishikawa , Atsuko Takamatsu

A system of two enzymes mechanically coupled to each other in a viscous medium was recently studied, and conditions for obtaining synchronization and an enhanced average rate of the thermally-activated catalytic reactions of the enzymes…

Statistical Mechanics · Physics 2023-09-29 Michalis Chatzittofi , Ramin Golestanian , Jaime Agudo-Canalejo

Large groups of active cilia collectively beat in a fluid medium as metachronal waves, essential for some microorganisms motility and for flow generation in mucociliary clearance. Several models can predict the emergence of metachronal…

Soft Condensed Matter · Physics 2024-05-08 Supravat Dey , Gladys Massiera , Estelle Pitard

Microorganisms develop coordinated beating patterns on surfaces lined with cilia known as metachronal waves. For a chain of cilia attached to a flat ciliate, it has been shown that hydrodynamic interactions alone can lead the system to…

Fluid Dynamics · Physics 2016-03-23 Babak Nasouri , Gwynn J. Elfring

Organisms use hair-like cilia that beat in a metachronal fashion to actively transport fluid and suspended particles. Metachronal motion emerges due to a phase difference between beating cycles of neighboring cilia and appears as traveling…

Fluid Dynamics · Physics 2018-06-13 Srinivas Hanasoge , Peter J. Hesketh , Alexander Alexeev
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