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An important component of every country's COVID-19 response is fast and efficient testing - to identify and isolate cases, as well as for early detection of local hotspots. For many countries, producing a sufficient number of tests has been…

Methodology · Statistics 2020-10-27 J. Batson , N. Bottman , Y. Cooper , F. Janda

Large scale disease screening is a complicated process in which high costs must be balanced against pressing public health needs. When the goal is screening for infectious disease, one approach is group testing in which samples are…

Applications · Statistics 2021-03-02 Gregory Haber , Yaakov Malinovsky , Paul S. Albert

We propose `Tapestry', a novel approach to pooled testing with application to COVID-19 testing with quantitative Reverse Transcription Polymerase Chain Reaction (RT-PCR) that can result in shorter testing time and conservation of reagents…

In one-stage or non-adaptive group testing, instead of testing every sample unit individually, they are split, bundled in pools, and simultaneously tested. The results are then decoded to infer the states of the individual items. This…

Applications · Statistics 2020-12-04 Christoph Schumacher , Matthias Täufer

We argue that frequent sampling of the fraction of infected people (either by random testing or by analysis of sewage water), is central to managing the COVID-19 pandemic because it both measures in real time the key variable controlled by…

Populations and Evolution · Quantitative Biology 2020-07-24 Markus Müller , Peter M. Derlet , Christopher Mudry , Gabriel Aeppli

Compressed sensing, which involves the reconstruction of sparse signals from an under-determined linear system, has been recently used to solve problems in group testing. In a public health context, group testing aims to determine the…

Applications · Statistics 2026-01-21 Shuvayan Banerjee , Radhendushka Srivastava , James Saunderson , Ajit Rajwade

Major advances in public health have resulted from disease prevention. However, prevention of a new infectious disease by vaccination or pharmaceuticals is made difficult by the slow process of vaccine and drug development. We propose an…

Populations and Evolution · Quantitative Biology 2021-04-15 Jussi Taipale , Ioannis Kontoyiannis , Sten Linnarsson

We consider real-time timely tracking of infection status (e.g., covid-19) of individuals in a population. In this work, a health care provider wants to detect infected people as well as people who have recovered from the disease as quickly…

Information Theory · Computer Science 2022-06-15 Melih Bastopcu , Sennur Ulukus

Despite of the fast development of highly effective vaccines to control the current COVID$-$19 pandemic, the unequal distribution and availability of these vaccines worldwide and the number of people infected in the world lead to the…

Using recent data from voluntary mass testing, I provide credible bounds on prevalence of SARS-CoV-2 for Austrian counties in early December 2020. When estimating prevalence, a natural missing data problem arises: no test results are…

General Economics · Economics 2020-12-23 Gabriel Ziegler

We propose two-stage adaptive pooling schemes, 2-STAP and 2-STAMP, for detecting COVID-19 using real-time reverse transcription quantitative polymerase chain reaction (RT-qPCR) test kits. Similar to the Tapestry scheme of Ghosh et al., the…

Information Theory · Computer Science 2020-07-07 Anoosheh Heidarzadeh , Krishna R. Narayanan

The experience of Singapur and South Korea makes it clear that under certain circumstances massive testing is an effective way for containing the advance of the COVID-19. In this paper, we propose a modified SEIR model which takes into…

Applications · Statistics 2020-12-24 José Luis Sainz-Pardo , José Valero

Pooled testing is widely used for screening for viral or bacterial infections with low prevalence when individual testing is not cost-efficient. Pooled testing with qualitative assays that give binary results has been well-studied. However,…

Methodology · Statistics 2020-11-03 Tao Liu , Joseph W Hogan , Wanning Su , Yizhen Xu , Michael J Daniels , Kantor Rami

Repeat asymptomatic testing in order to identify and quarantine infectious individuals has become a widely-used intervention to control SARS-CoV-2 transmission. In some workplaces, and in particular health and social care settings with…

Populations and Evolution · Quantitative Biology 2022-10-18 Carl A Whitfield , University of Manchester COVID-19 Modelling Group , Ian Hall

The group testing problem asks for efficient pooling schemes and algorithms that allow to screen moderately large numbers of samples for rare infections. The goal is to accurately identify the infected samples while conducting the least…

Artificial Intelligence · Computer Science 2021-05-19 AminCoja-Oghlan , Max Hahn-Klimroth , Philipp Loick , Manuel Penschuck

This paper examines the statistical properties of a distributional form that arises from pooled testing for the prevalence of a binary outcome. Our base distribution is a two-parameter distribution using a prevalence and excess intensity…

Methodology · Statistics 2021-08-11 Ben O'Neill , Angus McLure

In this paper, we study the pooled data problem of identifying the labels associated with a large collection of items, based on a sequence of pooled tests revealing the counts of each label within the pool. In the noiseless setting, we…

Machine Learning · Statistics 2017-10-19 Jonathan Scarlett , Volkan Cevher

There are many sources of data giving information about the number of SARS-CoV-2 infections in the population, but all have major drawbacks, including biases and delayed reporting. For example, the number of confirmed cases largely…

Applications · Statistics 2022-06-08 Nicholas J. Irons , Adrian E. Raftery

Group testing is an efficient method for testing a large population to detect infected individuals. In this paper, we consider an efficient adaptive two stage group testing scheme. Using a straightforward analysis, we characterize the…

Methodology · Statistics 2020-08-26 Arjun Kodialam

In order to slow the spread of the CoViD-19 pandemic, governments around the world have enacted a wide set of policies limiting the transmission of the disease. Initially, these focused on non-pharmaceutical interventions; more recently,…

Populations and Evolution · Quantitative Biology 2021-06-24 Janoś Gabler , Tobias Raabe , Klara Röhrl , Hans-Martin von Gaudecker