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Systems biology models are useful models of complex biological systems that may require a large amount of experimental data to fit each model's parameters or to approximate a likelihood function. These models range from a few to thousands…

Quantitative Methods · Quantitative Biology 2024-07-12 Vincent D. Zaballa , Elliot E. Hui

Modular design maximizes utility by using standardized components in large-scale systems. From a manufacturing perspective, it supports green technology by reducing material waste and improving reusability. Industrially, it offers economic…

Emerging Technologies · Computer Science 2025-03-18 Sumin Lee , Namwoo Kang

Structural variants compose the majority of human genetic variation, but are difficult to assess using current genomic sequencing technologies. Optical mapping technologies, which measure the size of chromosomal fragments between labeled…

Quantitative Methods · Quantitative Biology 2019-10-10 Weiwei Li , Jan Hannig , Corbin Jones

Systems engineering approaches use high-level models to capture the architecture and behavior of the system. However, when safety engineers conduct safety and reliability analysis, they have to create formal models, such as fault-trees,…

Software Engineering · Computer Science 2020-04-29 Simon József Nagy , Bence Graics , Kristóf Marussy , András Vörös

A novel method for performing model updating on finite element models is presented. The approach is particularly tailored to modal analyses of buildings, by which the lowest frequencies, obtained by using sensors and system identification…

Numerical Analysis · Mathematics 2018-07-18 Maria Girardi , Cristina Padovani , Daniele Pellegrini , Margherita Porcelli , Leonardo Robol

FRET experiments can yield state-specific structural information on complex dynamic biomolecular assemblies. However, FRET experiments need to be combined with computer simulations to overcome their sparsity. We introduce (i) an automated…

Quantitative Methods · Quantitative Biology 2019-09-11 Mykola Dimura , Thomas O. Peulen , Hugo Sanabria , Dmitro Rodnin , Katherina Hemmen , Claus A. M. Seidel , Holger Gohlke

Rigid-bodied robots often lack compliance needed to adapt to unstructured environments, while fully soft robots, though highly adaptable, struggle with scalability and load capacity. In nature, musculoskeletal systems balance strength and…

Computational Engineering, Finance, and Science · Computer Science 2026-05-29 Hiroki Kobayashi , Yuki Takaha , Changyoung Yuhn , Yuki Sato , Sunao Tomita , Atsushi Kawamoto , Tsuyoshi Nomura

Meta-materials are an important emerging class of engineered materials in which complex macroscopic behaviour--whether electromagnetic, thermal, or mechanical--arises from modular substructure. Simulation and optimization of these materials…

Machine Learning · Computer Science 2020-05-18 Alex Beatson , Jordan T. Ash , Geoffrey Roeder , Tianju Xue , Ryan P. Adams

The recent decades have seen various attempts at accelerating the process of developing materials targeted towards specific applications. The performance required for a particular application leads to the choice of a particular material…

Building practitioners (architects, engineers, energy managers) are showing a growing interest in the design of more energy efficient and livable buildings. The best way to predict how a building will behave regarding energy consumption and…

The design of the cross-section of an FRP-reinforced concrete beam is an iterative process of estimating both its dimensions and the reinforcement ratio, followed by the check of the compliance of a number of strength and serviceability…

Neural and Evolutionary Computing · Computer Science 2021-01-26 M. S. Innocente , Ll. Torres , X. Cahís , G. Barbeta , A. Catalán

Algorithm design is a laborious process and often requires many iterations of ideation and validation. In this paper, we explore automating algorithm design and present a method to learn an optimization algorithm, which we believe to be the…

Machine Learning · Computer Science 2016-06-07 Ke Li , Jitendra Malik

One of the key problems in tensor network based quantum circuit simulation is the construction of a contraction tree which minimizes the cost of the simulation, where the cost can be expressed in the number of operations as a proxy for the…

Quantum Physics · Physics 2022-09-08 Cameron Ibrahim , Danylo Lykov , Zichang He , Yuri Alexeev , Ilya Safro

Integrating uncertainties in the design process of reinforced concrete rail bridges, in a fully probabilistic framework, makes their design more complex and challenging. To propagate these uncertainties and convey their influence on the…

Numerical Analysis · Mathematics 2025-11-13 Mouhammed Achhab , Pierre Jehel , Fabrice Gatuingt

Simulation is often used to evaluate the relevance of a Directing Program of Production (PDP) or to evaluate its impact on detailed sc\'enarii of scheduling. Within this framework, we propose to reduce the complexity of a model of…

Neural and Evolutionary Computing · Computer Science 2008-12-08 Philippe Thomas , André Thomas

While machine learning models are typically trained to solve prediction problems, we might often want to use them for optimization problems. For example, given a dataset of proteins and their corresponding fluorescence levels, we might want…

Machine Learning · Computer Science 2024-10-18 Jakub Grudzien Kuba , Masatoshi Uehara , Pieter Abbeel , Sergey Levine

A major goal of materials design is to find material structures with desired properties and in a second step to find a processing path to reach one of these structures. In this paper, we propose and investigate a deep reinforcement learning…

Machine Learning · Computer Science 2021-07-09 Johannes Dornheim , Lukas Morand , Samuel Zeitvogel , Tarek Iraki , Norbert Link , Dirk Helm

The field of optimal design of linear elastic structures has seen many exciting successes that resulted in new architected materials and structural designs. With the availability of cloud computing, including high-performance computing,…

Computational Engineering, Finance, and Science · Computer Science 2021-02-09 Diab W. Abueidda , Seid Koric , Nahil A. Sobh

Optimization via simulation has been well established to find optimal solutions and designs in complex systems. However, it still faces modeling and computational challenges when extended to the multi-stage setting. This survey reviews the…

Optimization and Control · Mathematics 2023-12-08 Zhuo Zhang , Dan Wang , Haoxiang Yang , Shubin Si

Fast and accurate structural dynamics analysis is important for structural design and damage assessment. Structural dynamics analysis leveraging machine learning techniques has become a popular research focus in recent years. Although the…

Geophysics · Physics 2020-12-29 Yuan Feng , Hexiang Wang , Han Yang , Fangbo Wang
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