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Dendritic spines are key structural components of excitatory synapses in the brain. Given the size of dendritic spines provides a proxy for synaptic efficacy, their detection and tracking across time is important for studies of the neural…
In radial fast spin-echo MRI, a set of overlapping spokes with an inconsistent T2 weighting is acquired, which results in an averaged image contrast when employing conventional image reconstruction techniques. This work demonstrates that…
Magnetic resonance fingerprinting (MRF) provides a unique concept for simultaneous and fast acquisition of multiple quantitative MR parameters. Despite acquisition efficiency, adoption of MRF into the clinics is hindered by its dictionary…
Medical image denoising is essential for improving the reliability of clinical diagnosis and guiding subsequent image-based tasks. In this paper, we propose a multi-scale approach that integrates anisotropic Gaussian filtering with…
Accurate segmentation of spinal structures in X-ray images is a prerequisite for quantitative scoliosis assessment, including Cobb angle measurement, vertebral translation estimation and curvature classification. In routine practice,…
This paper deals with the highly challenging problem of reconstructing the shape of a refracting object from a single image of its resulting caustic. Due to the ubiquity of transparent refracting objects in everyday life, reconstruction of…
In multi-photon microscopy (MPM), a recent in-vivo fluorescence microscopy system, the task of image restoration can be decomposed into two interlinked inverse problems: firstly, the characterization of the Point Spread Function (PSF) and…
Designing implants for large and complex cranial defects is a challenging task, even for professional designers. Current efforts on automating the design process focused mainly on convolutional neural networks (CNN), which have produced…
A model-based reconstruction technique for accelerated T2 mapping with improved accuracy is proposed using undersampled Cartesian spin-echo MRI data. The technique employs an advanced signal model for T2 relaxation that accounts for…
Automated sample preparation and electron microscopy enables acquisition of very large image data sets. These technical advances are of special importance to the field of neuroanatomy, as 3D reconstructions of neuronal processes at the nm…
Light microscopy is a widespread and inexpensive imaging technique facilitating biomedical discovery and diagnostics. However, light diffraction barrier and imperfections in optics limit the level of detail of the acquired images. The…
We propose approaches based on deep learning to localize objects in images when only a small training dataset is available and the images have low quality. That applies to many problems in medical image processing, and in particular to the…
This paper presents a new variational inference framework for image restoration and a convolutional neural network (CNN) structure that can solve the restoration problems described by the proposed framework. Earlier CNN-based image…
Surface reconstruction from magnetic resonance (MR) imaging data is indispensable in medical image analysis and clinical research. A reliable and effective reconstruction tool should: be fast in prediction of accurate well localised and…
Endoscopy is essential in medical imaging, used for diagnosis, prognosis and treatment. Developing a robust dynamic 3D reconstruction pipeline for endoscopic videos could enhance visualization, improve diagnostic accuracy, aid in treatment…
MRI is preferred over CT in paediatric imaging because it avoids ionising radiation, but its use in spine deformity assessment is largely limited by the lack of automated, high-resolution 3D bony reconstruction, which continues to rely on…
Data driven segmentation is an important initial step of shape prior-based segmentation methods since it is assumed that the data term brings a curve to a plausible level so that shape and data terms can then work together to produce better…
Fourier ptychographic microscopy (FPM) is a recently developed computational imaging technique for wide-field, high-resolution microscopy with a high space-bandwidth product. It integrates the concepts of synthetic aperture and phase…
Automated detection of sclerotic metastases (bone lesions) in Computed Tomography (CT) images has potential to be an important tool in clinical practice and research. State-of-the-art methods show performance of 79% sensitivity or…
Magnetic Resonance (MR) Fingerprinting is an emerging multi-parametric quantitative MR imaging technique, for which image reconstruction methods utilizing low-rank and subspace constraints have achieved state-of-the-art performance.…