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The essence of precision oncology lies in its commitment to tailor targeted treatments and care measures to each patient based on the individual characteristics of the tumor. The inherent heterogeneity of tumors necessitates gathering…

Quantitative Methods · Quantitative Biology 2024-07-01 Huajun Zhou , Fengtao Zhou , Chenyu Zhao , Yingxue Xu , Luyang Luo , Hao Chen

Breast cancer is a significant global health issue, and the diagnosis of breast cancer through imaging remains challenging. Mammography images are characterized by extremely high resolution, while lesions often occupy only a small portion…

Tissues and Organs · Quantitative Biology 2025-07-28 Shilong Yang , Chulong Zhang , Xiaokun Liang , Qi Zang , Juan Yu , Liang Zeng , Xiao Luo , Yexuan Xing , Xin Pan , Qi Li , Linlin Shen , Yaoqin Xie

Continuous response variables often need to be transformed to meet regression modeling assumptions; however, finding the optimal transformation is challenging and results may vary with the choice of transformation. When a continuous…

Methodology · Statistics 2022-07-19 Yuqi Tian , Bryan E. Shepherd , Chun Li , Donglin Zeng , Jonathan J. Schildcrout

Multi-view clustering can explore common semantics from multiple views and has received increasing attention in recent years. However, current methods focus on learning consistency in representation, neglecting the contribution of each…

Computer Vision and Pattern Recognition · Computer Science 2025-04-08 Bo Li , Jing Yun

Model-based clustering is a popular approach for clustering multivariate data which has seen applications in numerous fields. Nowadays, high-dimensional data are more and more common and the model-based clustering approach has adapted to…

Methodology · Statistics 2018-09-25 Michael Fop , Thomas Brendan Murphy

There are relatively few works dealing with conformal prediction for multi-task learning issues, and this is particularly true for multi-target regression. This paper focuses on the problem of providing valid (i.e., frequency calibrated)…

Machine Learning · Computer Science 2021-01-29 Soundouss Messoudi , Sébastien Destercke , Sylvain Rousseau

In recent years, conditional copulas, that allow dependence between variables to vary according to the values of one or more covariates, have attracted increasing attention. In high dimension, vine copulas offer greater flexibility compared…

Methodology · Statistics 2021-09-24 Rosario Barone , Luciana Dalla Valle

We propose an algorithm for clustering high dimensional data. If $P$ features for $N$ objects are represented in an $N\times P$ matrix ${\bf X}$, where $N\ll P$, the method is based on exploiting the cluster-dependent structure of the…

Machine Learning · Statistics 2018-11-05 Shahina Rahman , Valen E. Johnson

We introduce a new computer aided detection and diagnosis system for lung cancer screening with low-dose CT scans that produces meaningful probability assessments. Our system is based entirely on 3D convolutional neural networks and…

Computer Vision and Pattern Recognition · Computer Science 2020-01-22 Onur Ozdemir , Rebecca L. Russell , Andrew A. Berlin

The two most extended density-based approaches to clustering are surely mixture model clustering and modal clustering. In the mixture model approach, the density is represented as a mixture and clusters are associated to the different…

Machine Learning · Statistics 2016-09-16 José E. Chacón

This paper proposes different methods to consistently detect multiple breaks in copula-based dependence measures, mainly focusing on Spearman's $\rho$. The leading model is a factor copula model due to its usefulness for analyzing data in…

Methodology · Statistics 2022-06-13 Marvin Borsch , Alexander Mayer , Dominik Wied

Clustering is a fundamental machine learning task which has been widely studied in the literature. Classic clustering methods follow the assumption that data are represented as features in a vectorized form through various representation…

Machine Learning · Computer Science 2022-06-16 Sheng Zhou , Hongjia Xu , Zhuonan Zheng , Jiawei Chen , Zhao li , Jiajun Bu , Jia Wu , Xin Wang , Wenwu Zhu , Martin Ester

The Cancer Genome Atlas (TCGA) has enabled novel discoveries and served as a large-scale reference dataset in cancer through its harmonized genomics, clinical, and imaging data. Numerous prior studies have developed bespoke deep learning…

Machine Learning · Computer Science 2026-05-11 Steven Song , Morgan Borjigin-Wang , Irene Madejski , Robert L. Grossman

Multi-view learning methods often focus on improving decision accuracy, while neglecting the decision uncertainty, limiting their suitability for safety-critical applications. To mitigate this, researchers propose trusted multi-view…

Machine Learning · Computer Science 2024-10-08 Ying Liu , Lihong Liu , Cai Xu , Xiangyu Song , Ziyu Guan , Wei Zhao

Technological advances have enabled the generation of unique and complementary types of data or views (e.g. genomics, proteomics, metabolomics) and opened up a new era in multiview learning research with the potential to lead to new…

Machine Learning · Computer Science 2024-02-19 Hengkang Wang , Han Lu , Ju Sun , Sandra E Safo

Cancer is a complex disease that provides various types of information depending on the scale of observation. While most tumor diagnostics are performed by observing histopathological slides, radiology images should yield additional…

Image and Video Processing · Electrical Eng. & Systems 2020-10-07 Marvin Lerousseau , Eric Deutsh , Nikos Paragios

Incomplete multi-view clustering is a challenging and non-trivial task to provide effective data analysis for large amounts of unlabeled data in the real world. All incomplete multi-view clustering methods need to address the problem of how…

Machine Learning · Computer Science 2023-05-22 Sifan Fang

We study the task of unsupervised domain adaptation, where no labeled data from the target domain is provided during training time. To deal with the potential discrepancy between the source and target distributions, both in features and…

Machine Learning · Computer Science 2017-10-03 Cuong D. Tran , Ognjen Rudovic , Vladimir Pavlovic

A new depth-based clustering procedure for directional data is proposed. Such method is fully non-parametric and has the advantages to be flexible and applicable even in high dimensions when a suitable notion of depth is adopted. The…

Methodology · Statistics 2022-06-22 Giuseppe Pandolfo , Antonio D'ambrosio

Modern high-throughput sequencing technologies have enabled us to profile multiple molecular modalities from the same single cell, providing unprecedented opportunities to assay celluar heterogeneity from multiple biological layers.…

Machine Learning · Statistics 2022-05-20 Pengcheng Zeng , Zhixiang Lin