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Gene expression is a cellular process that plays a fundamental role in human phenotypical variations and diseases. Despite advances of deep learning models for gene expression prediction, recent benchmarks have revealed their inability to…

Cell Behavior · Quantitative Biology 2024-10-04 Edouardo Honig , Huixin Zhan , Ying Nian Wu , Zijun Frank Zhang

Registration is the process that computes the transformation that aligns sets of data. Commonly, a registration process can be divided into four main steps: target selection, feature extraction, feature matching, and transform computation…

Computer Vision and Pattern Recognition · Computer Science 2020-10-29 Victor Villena-Martinez , Sergiu Oprea , Marcelo Saval-Calvo , Jorge Azorin-Lopez , Andres Fuster-Guillo , Robert B. Fisher

The capability of accurate prediction of protein functions and properties is essential in the biotechnology industry, e.g. drug development and artificial protein synthesis, etc. The main challenges of protein function prediction are the…

Quantitative Methods · Quantitative Biology 2021-12-02 Wei-Cheng Tseng , Po-Han Chi , Jia-Hua Wu , Min Sun

Despite the great promise of Transformers in many sequence modeling tasks (e.g., machine translation), their deterministic nature hinders them from generalizing to high entropy tasks such as dialogue response generation. Previous work…

Computation and Language · Computer Science 2020-03-31 Zhaojiang Lin , Genta Indra Winata , Peng Xu , Zihan Liu , Pascale Fung

Several processes in the cell, such as gene regulation, start when key proteins recognise and bind to short DNA sequences. However, as these sequences can be hundreds of million times shorter than the genome, they are hard to find by simple…

Subcellular Processes · Quantitative Biology 2021-01-27 Markus Nyberg , Tobias Ambjörnsson , Per Stenberg , and Ludvig Lizana

We present a novel approach for training deep neural networks in a Bayesian way. Classical, i.e. non-Bayesian, deep learning has two major drawbacks both originating from the fact that network parameters are considered to be deterministic.…

Machine Learning · Statistics 2019-03-11 Konstantin Posch , Jan Steinbrener , Jürgen Pilz

Many structured prediction tasks in machine vision have a collection of acceptable answers, instead of one definitive ground truth answer. Segmentation of images, for example, is subject to human labeling bias. Similarly, there are multiple…

Computer Vision and Pattern Recognition · Computer Science 2020-08-26 Michael Firman , Neill D. F. Campbell , Lourdes Agapito , Gabriel J. Brostow

Embedding is a useful technique to project a high-dimensional feature into a low-dimensional space, and it has many successful applications including link prediction, node classification and natural language processing. Current approaches…

Information Retrieval · Computer Science 2020-09-21 Meimei Liu , Hongxia Yang

Emerging diseases present challenges in symptom recognition and timely clinical intervention due to limited available information. An effective prognostic model could assist physicians in making accurate diagnoses and designing personalized…

Machine Learning · Computer Science 2025-02-12 Zhongji Zhang , Yuhang Wang , Yinghao Zhu , Xinyu Ma , Yasha Wang , Junyi Gao , Liantao Ma , Wen Tang , Xiaoyun Zhang , Ling Wang

Transfer learning research attempts to make model induction transferable across different domains. This method assumes that specific information regarding to which domain each instance belongs is known. This paper helps to extend the…

Machine Learning · Computer Science 2025-06-04 Xinshun Liu , He Xin , Mao Hui , Liu Jing , Lai Weizhong , Ye Qingwen

Motivation: Array Comparative Genomic Hybridization (aCGH) is used to scan the entire genome for variations in DNA copy number. A central task in the analysis of aCGH data is the segmentation into groups of probes sharing the same DNA copy…

Quantitative Methods · Quantitative Biology 2008-04-29 Erez Ben-Yaacov , Yonina Eldar

It has been shown that deep learning models can under certain circumstances outperform traditional statistical methods at forecasting. Furthermore, various techniques have been developed for quantifying the forecast uncertainty (prediction…

Machine Learning · Computer Science 2021-10-08 Thabang Mathonsi , Terence L. van Zyl

To deploy and operate deep neural models in production, the quality of their predictions, which might be contaminated benignly or manipulated maliciously by input distributional deviations, must be monitored and assessed. Specifically, we…

Computer Vision and Pattern Recognition · Computer Science 2023-06-09 Guy Bar-Shalom , Yonatan Geifman , Ran El-Yaniv

Generative Adversarial Network (GAN) and its variants have recently attracted intensive research interests due to their elegant theoretical foundation and excellent empirical performance as generative models. These tools provide a promising…

Machine Learning · Computer Science 2018-02-20 Liyang Xie , Kaixiang Lin , Shu Wang , Fei Wang , Jiayu Zhou

Various Graph Neural Networks (GNNs) have been successful in analyzing data in non-Euclidean spaces, however, they have limitations such as oversmoothing, i.e., information becomes excessively averaged as the number of hidden layers…

Machine Learning · Computer Science 2024-01-23 Jaeyoon Sim , Sooyeon Jeon , InJun Choi , Guorong Wu , Won Hwa Kim

Ordinary stochastic neural networks mostly rely on the expected values of their weights to make predictions, whereas the induced noise is mostly used to capture the uncertainty, prevent overfitting and slightly boost the performance through…

Machine Learning · Statistics 2019-02-19 Kirill Neklyudov , Dmitry Molchanov , Arsenii Ashukha , Dmitry Vetrov

Deep Neural Networks (DNNs) demonstrate remarkable capabilities in learning complex hierarchical data representations, but the nature of these representations remains largely unknown. Existing global explainability methods, such as Network…

Machine Learning · Computer Science 2024-01-19 Kirill Bykov , Laura Kopf , Shinichi Nakajima , Marius Kloft , Marina M. -C. Höhne

Deep learning based image segmentation has achieved the state-of-the-art performance in many medical applications such as lesion quantification, organ detection, etc. However, most of the methods rely on supervised learning, which require a…

Computer Vision and Pattern Recognition · Computer Science 2020-04-20 Ruizhe Li , Dorothee Auer , Christian Wagner , Xin Chen

Structural changes in a network representation of a system (e.g.,different experimental conditions, time evolution), can provide insight on its organization, function and on how it responds to external perturbations. The deeper…

Data Analysis, Statistics and Probability · Physics 2021-01-04 Leonardo L. Portes , Michael Small

An essential part for the accurate classification of electrocardiogram (ECG) signals is the extraction of informative yet general features, which are able to discriminate diseases. Cardiovascular abnormalities manifest themselves in…

Signal Processing · Electrical Eng. & Systems 2024-07-11 Maximilian P Oppelt , Maximilian Riehl , Felix P Kemeth , Jan Steffan
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