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Machine learning (ML) has been playing important roles in drug discovery in the past years by providing (pre-)screening tools for prioritising chemical compounds to pass through wet lab experiments. One of the main ML tasks in drug…

Biomolecules · Quantitative Biology 2025-02-25 Alex G. C. de Sá , David B. Ascher

Model-agnostic meta-learning (MAML) has emerged as one of the most successful meta-learning techniques in few-shot learning. It enables us to learn a meta-initialization} of model parameters (that we call meta-model) to rapidly adapt to new…

Machine Learning · Computer Science 2021-02-23 Ren Wang , Kaidi Xu , Sijia Liu , Pin-Yu Chen , Tsui-Wei Weng , Chuang Gan , Meng Wang

While deep networks can learn complex functions such as classifiers, detectors, and trackers, many applications require models that continually adapt to changing input distributions, changing tasks, and changing environmental conditions.…

Machine Learning · Computer Science 2022-02-21 Jathushan Rajasegaran , Chelsea Finn , Sergey Levine

Although Gaussian processes (GPs) with deep kernels have been successfully used for meta-learning in regression tasks, its uncertainty estimation performance can be poor. We propose a meta-learning method for calibrating deep kernel GPs for…

Machine Learning · Statistics 2023-12-14 Tomoharu Iwata , Atsutoshi Kumagai

The representations of the Earth's surface vary from one geographic region to another. For instance, the appearance of urban areas differs between continents, and seasonality influences the appearance of vegetation. To capture the diversity…

Machine Learning · Computer Science 2020-04-29 Marc Rußwurm , Sherrie Wang , Marco Körner , David Lobell

Deep neural state-space models (SSMs) provide a powerful tool for modeling dynamical systems solely using operational data. Typically, neural SSMs are trained using data collected from the actual system under consideration, despite the…

Machine Learning · Computer Science 2022-11-16 Ankush Chakrabarty , Gordon Wichern , Christopher R. Laughman

Model-agnostic meta-learning (MAML) is arguably one of the most popular meta-learning algorithms nowadays. Nevertheless, its performance on few-shot classification is far behind many recent algorithms dedicated to the problem. In this…

Machine Learning · Computer Science 2022-07-12 Han-Jia Ye , Wei-Lun Chao

Model Agnostic Meta-Learning (MAML) is one of the most representative of gradient-based meta-learning algorithms. MAML learns new tasks with a few data samples using inner updates from a meta-initialization point and learns the…

Machine Learning · Computer Science 2021-03-04 Jaehoon Oh , Hyungjun Yoo , ChangHwan Kim , Se-Young Yun

Machine learning and deep learning have gained popularity and achieved immense success in Drug discovery in recent decades. Historically, machine learning and deep learning models were trained on either structural data or chemical…

Machine Learning · Statistics 2019-09-18 Huy Ngoc Pham , Trung Hoang Le

Machine learning (ML) pipeline composition and optimisation have been studied to seek multi-stage ML models, i.e. preprocessor-inclusive, that are both valid and well-performing. These processes typically require the design and traversal of…

Machine Learning · Computer Science 2021-05-04 Tien-Dung Nguyen , David Jacob Kedziora , Katarzyna Musial , Bogdan Gabrys

The explosion of digital data has created multiple opportunities for organizations and individuals to leverage machine learning (ML) to transform the way they operate. However, the shortage of experts in the field of machine learning --…

Machine Learning · Computer Science 2019-11-21 Doron Laadan , Roman Vainshtein , Yarden Curiel , Gilad Katz , Lior Rokach

Large language models are powerful but costly. We ask whether meta-learning can make the pretraining of small language models not only better but also more interpretable. We integrate first-order MAML with subset-masked LM pretraining,…

Computation and Language · Computer Science 2025-11-10 David Demitri Africa , Yuval Weiss , Paula Buttery , Richard Diehl Martinez

Gene expression profiles obtained through DNA microarray have proven successful in providing critical information for cancer detection classifiers. However, the limited number of samples in these datasets poses a challenge to employ complex…

Machine Learning · Computer Science 2024-08-20 Arya Hadizadeh Moghaddam , Mohsen Nayebi Kerdabadi , Cuncong Zhong , Zijun Yao

Molecular property is usually observed with a limited number of samples, and researchers have considered property prediction as a few-shot problem. One important fact that has been ignored by prior works is that each molecule can be…

Machine Learning · Computer Science 2023-06-30 Xiang Zhuang , Qiang Zhang , Bin Wu , Keyan Ding , Yin Fang , Huajun Chen

This paper introduces Domain Generalization Sharpness-Aware Minimization Model-Agnostic Meta-Learning (DGS-MAML), a novel meta-learning algorithm designed to generalize across tasks with limited training data. DGS-MAML combines gradient…

Machine Learning · Computer Science 2025-08-14 Usman Anjum , Chris Stockman , Cat Luong , Justin Zhan

Machine learning (ML) enables accurate and fast molecular property predictions, which are of interest in drug discovery and material design. Their success is based on the principle of similarity at its heart, assuming that similar molecules…

Computational Engineering, Finance, and Science · Computer Science 2026-01-09 Fang Wu

Low-cost particulate matter sensors are transforming air quality monitoring because they have lower costs and greater mobility as compared to reference monitors. Calibration of these low-cost sensors requires training data from co-deployed…

Machine Learning · Computer Science 2021-08-03 Kalpit Yadav , Vipul Arora , Sonu Kumar Jha , Mohit Kumar , Sachchida Nand Tripathi

In the context of few-shot learning, it is currently believed that a fixed pre-trained (PT) model, along with fine-tuning the final layer during evaluation, outperforms standard meta-learning algorithms. We re-evaluate these claims under an…

Machine Learning · Computer Science 2025-09-24 Brando Miranda , Patrick Yu , Saumya Goyal , Yu-Xiong Wang , Sanmi Koyejo

Although model-agnostic meta-learning (MAML) is a very successful algorithm in meta-learning practice, it can have high computational cost because it updates all model parameters over both the inner loop of task-specific adaptation and the…

Machine Learning · Computer Science 2020-10-26 Kaiyi Ji , Jason D. Lee , Yingbin Liang , H. Vincent Poor

Widely used traditional supervised deep learning methods require a large number of training samples but often fail to generalize on unseen datasets. Therefore, a more general application of any trained model is quite limited for medical…

Computer Vision and Pattern Recognition · Computer Science 2022-02-01 Rabindra Khadga , Debesh Jha , Steven Hicks , Vajira Thambawita , Michael A. Riegler , Sharib Ali , Pål Halvorsen
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