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The association between a person's physical activity and various health outcomes is an area of active research. The National Health and Nutrition Examination Survey (NHANES) data provide a valuable resource for studying these associations.…

Applications · Statistics 2021-06-01 Bohan Wu , Bradley Van Allen

Background: Clinical trials are designed to prove the efficacy of an intervention by means of model-based approaches involving parametric hypothesis testing. Issues arise when no effect is observed in the study population. Indeed, an effect…

The identification of patient subgroups with comparable event-risk dynamics plays a key role in supporting informed decision-making in clinical research. In such settings, it is important to account for the inherent dependence that arises…

Computation · Statistics 2026-01-13 Alessandra Ragni , Lara Cavinato , Francesca Ieva

In this paper, we consider clustering based on principal component analysis (PCA) for high-dimension, low-sample-size (HDLSS) data. We give theoretical reasons why PCA is effective for clustering HDLSS data. First, we derive a geometric…

Statistics Theory · Mathematics 2015-03-17 Kazuyoshi Yata , Makoto Aoshima

Due to advances in sensors, growing large and complex medical image data have the ability to visualize the pathological change in the cellular or even the molecular level or anatomical changes in tissues and organs. As a consequence, the…

Machine Learning · Statistics 2016-02-17 Nan Lin , Junhai Jiang , Shicheng Guo , Momiao Xiong

In this paper, we discuss the impact of some mortality data anomalies on an internal model capturing longevity risk in the Solvency 2 framework. In particular, we are concerned with abnormal cohort effects such as those for generations 1919…

Risk Management · Quantitative Finance 2020-09-02 Fabrice Balland , Alexandre Boumezoued , Laurent Devineau , Marine Habart , Tom Popa

Analysis of child mortality is crucial as it pertains to the policy and programs of a country. The early assessment of patterns and trends in causes of child mortality help decision-makers assess needs, prioritize interventions, and monitor…

Computers and Society · Computer Science 2020-11-20 Asadullah Hill Galib , Nadia Nahar , B M Mainul Hossain

Functional linear discriminant analysis (FLDA) is a powerful tool that extends LDA-mediated multiclass classification and dimension reduction to univariate time-series functions. However, in the age of large multivariate and incomplete…

Machine Learning · Computer Science 2026-04-23 Rahul Bordoloi , Clémence Réda , Orell Trautmann , Saptarshi Bej , Olaf Wolkenhauer

Improving the future of healthcare starts by better understanding the current actual practices in hospital settings. This motivates the objective of discovering typical care pathways from patient data. Revealing typical care pathways can be…

Machine Learning · Computer Science 2024-12-20 Thomas Guyet , Pierre Pinson , Enoal Gesny

The adoption of probabilistic models for the best individuals found so far is a powerful approach for evolutionary computation. Increasingly more complex models have been used by estimation of distribution algorithms (EDAs), which often…

Neural and Evolutionary Computing · Computer Science 2007-10-16 Leonardo Emmendorfer , Aurora Pozo

Digital health technologies enable high-frequency collection of data in near-continuous time and capture rich information about the health of individuals. The raw data collected by these devices often have a hierarchical functional…

Clustering algorithms aim to organize data into groups or clusters based on the inherent patterns and similarities within the data. They play an important role in today's life, such as in marketing and e-commerce, healthcare, data…

Machine Learning · Computer Science 2024-01-17 Hui Yin , Amir Aryani , Stephen Petrie , Aishwarya Nambissan , Aland Astudillo , Shengyuan Cao

Federated learning (FL) is a distributed learning method that offers medical institutes the prospect of collaboration in a global model while preserving the privacy of their patients. Although most medical centers conduct similar medical…

Machine Learning · Computer Science 2022-07-08 Yousef Yeganeh , Azade Farshad , Johann Boschmann , Richard Gaus , Maximilian Frantzen , Nassir Navab

Clustering multimorbidity has been a global research priority in recent years. Existing studies usually identify these clusters using one of several popular clustering methods and then explore various characteristics of these clusters,…

Applications · Statistics 2025-05-06 Sohan Seth , Nazir Lone , Niels Peek , Bruce Guthrie

Federated clustering (FC) is an extension of centralized clustering in federated settings. The key here is how to construct a global similarity measure without sharing private data, since the local similarity may be insufficient to group…

Machine Learning · Computer Science 2023-10-24 Jie Yan , Jing Liu , Ji Qi , Zhong-Yuan Zhang

This paper explores the critical role of data clustering in data science, emphasizing its methodologies, tools, and diverse applications. Traditional techniques, such as partitional and hierarchical clustering, are analyzed alongside…

Artificial Intelligence · Computer Science 2025-10-07 Tai Dinh , Wong Hauchi , Daniil Lisik , Michal Koren , Dat Tran , Philip S. Yu , Joaquín Torres-Sospedra

In recent times, functional data analysis (FDA) has been successfully applied in the field of high dimensional data classification. In this paper, we present a novel classification framework using functional data and classwise Principal…

Machine Learning · Statistics 2021-06-29 Avishek Chatterjee , Satyaki Mazumder , Koel Das

Functional concurrent, or varying-coefficient, regression models are commonly used in biomedical and clinical settings to investigate how the relation between an outcome and observed covariate varies as a function of another covariate. In…

Survival analysis aims to predict the timing of future events across various fields, from medical outcomes to customer churn. However, the integration of clustering into survival analysis, particularly for precision medicine, remains…

Machine Learning · Computer Science 2024-05-28 Gabriel Buginga , Edmundo de Souza e Silva

Functional Principal Components Analysis (FPCA) is a widely used analytic tool for dimension reduction of functional data. Traditional implementations of FPCA estimate the principal components from the data, then treat these estimates as…

Methodology · Statistics 2026-04-03 Joseph Sartini , Xinkai Zhou , Liz Selvin , Scott Zeger , Ciprian Crainiceanu