Related papers: A Mathematical Model of Platelet Aggregation in an…
When a blood vessel ruptures or gets inflamed, the human body responds by rapidly forming a clot to restrict the loss of blood. Platelets aggregation at the injury site of the blood vessel occurring via platelet-platelet adhesion, tethering…
Primary hemostasis is initiated by platelet adhesion and aggregation at a site of vascular injury and is strongly regulated by local hydrodynamic conditions. At elevated shear rates, platelet capture is mediated by von Willebrand factor…
Platelet adhesion and aggregation are essential for primary hemostasis, forming a clot that quickly stops initial bleeding. Despite this critical role, the dynamic interactions of platelet receptors with exposed collagen and von Willebrand…
Interfacing atomistic-based with continuum-based simulation codes is now required in many multiscale physical and biological systems. We present the first results from coupled atomistic-continuum simulations on 190,000 processors. Platelet…
The early stages of clot formation in blood vessels involve platelets adhesion-aggregation. Although these mechanisms have been extensively studied, gaps in their understanding still persist. We have performed detailed in-vitro experiments…
During the formation of a thrombus, the architecture of the growing platelet aggregate is heterogeneous, with areas of dense and loosely packed platelets. The surface of activated platelets facilitate biochemical coagulation reactions that…
A noteworthy aspect in blood flow modeling is the definition of the mechanical interaction between the fluid flow and the biological structure that contains it, namely the vessel wall. It has been demonstrated that the addition of a viscous…
Blood clotting involves the coupled processes of platelet aggregation and coagulation. Simulating clotting under flow in complex geometries is challenging due to multiple temporal and spatial scales and high computational cost. clotFoam is…
Atherosclerosis is a chronic inflammatory disease occurs due to plaque accumulation in the inner artery wall. In atherosclerotic plaque formation monocytes and macrophages play a significant role in controlling the disease dynamics. In the…
Mathematical models are widely recognized as a valuable tool for cardiovascular diagnosis and the study of circulatory diseases, especially to obtain data that require otherwise invasive measurements. To correctly simulate body…
Mathematical models and numerical simulations are widely used in the field of hemodynamics, representing a valuable resource to better understand physiological and pathological processes. The theory behind the phenomenon is closely related…
We present a unified mathematical framework for modeling blood and lymph flow in biological vessels, with a particular focus on lymph transport through lymphangions. Starting from first principles, we rigorously derive a system of partial…
Occlusive thrombosis in arteries causes heart attacks and strokes. The rapid growth of thrombus at elevated shear rates (~10,000 1/s) relies on shear-induced platelet aggregation (SIPA) thought to come about from the entanglement of von…
In this paper, we present a mathematical and numerical model for blood solidification and its rupture in stenosed arteries. The interaction between the blood flow and an existing stenosis in the arterial wall is modeled as a three…
We propose a one-way coupled model that tracks individual primary particles in a conceptually simple cellular flow setup to predict flocculation in turbulence. This computationally efficient model accounts for Stokes drag, lubrication,…
Microfluidic technology has emerged as a powerful tool for studying complex biological processes with enhanced precision and control. A microfluidic chip was designed to emulate human-like microvascular networks with precise control over…
We present a model appropriate to the initial motion (2-3 chords of travel) of a flat-plate airfoil accelerating in an inviscid fluid. The separated flow structures are represented as vortex sheets in the conventional manner and similarity…
We report detailed microscopic studies of asphaltenes aggregation onset during waterflooding of petroleum reservoirs. To achieve this objective, a series of simulations are performed on asphaltenic-oil miscibilized with water at high…
Human blood flow is a multi-scale problem: in first approximation, blood is a dense suspension of plasma and deformable red cells. Physiological vessel diameters range from about one to thousands of cell radii. Current computational models…
In the last years, medical computer simulation has seen a great growth in several scientific branches, from modelling to numerical methods, going through computer science. The main goals of this incipient discipline are testing hypotheses…