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Despite advances in data augmentation and transfer learning, convolutional neural networks (CNNs) difficultly generalise to unseen domains. When segmenting brain scans, CNNs are highly sensitive to changes in resolution and contrast: even…

Image and Video Processing · Electrical Eng. & Systems 2023-03-01 Benjamin Billot , Douglas N. Greve , Oula Puonti , Axel Thielscher , Koen Van Leemput , Bruce Fischl , Adrian V. Dalca , Juan Eugenio Iglesias

Retrospective analysis of brain MRI scans acquired in the clinic has the potential to enable neuroimaging studies with sample sizes much larger than those found in research datasets. However, analysing such clinical images "in the wild" is…

Image and Video Processing · Electrical Eng. & Systems 2023-01-06 Benjamin Billot , Magdamo Colin , Sean E. Arnold , Sudeshna Das , Juan. E. Iglesias

Magnetic resonance imaging (MRI) has played a crucial role in fetal neurodevelopmental research. Structural annotations of MR images are an important step for quantitative analysis of the developing human brain, with Deep Learning providing…

Brain segmentation from neonatal MRI images is a very challenging task due to large changes in the shape of cerebral structures and variations in signal intensities reflecting the gestational process. In this context, there is a clear need…

Machine Learning · Statistics 2023-09-12 R Valabregue , F Girka , A Pron , F Rousseau , G Auzias

Every year, millions of brain MRI scans are acquired in hospitals, which is a figure considerably larger than the size of any research dataset. Therefore, the ability to analyse such scans could transform neuroimaging research. Yet, their…

Image and Video Processing · Electrical Eng. & Systems 2023-03-29 Benjamin Billot , Colin Magdamo , You Cheng , Steven E. Arnold , Sudeshna Das , Juan. E. Iglesias

Deep learning approaches to the segmentation of magnetic resonance images have shown significant promise in automating the quantitative analysis of brain images. However, a continuing challenge has been its sensitivity to the variability of…

Image and Video Processing · Electrical Eng. & Systems 2021-03-05 Dzung L. Pham , Yi-Yu Chou , Blake E. Dewey , Daniel S. Reich , John A. Butman , Snehashis Roy

Probabilistic atlas priors have been commonly used to derive adaptive and robust brain MRI segmentation algorithms. Widely-used neuroimage analysis pipelines rely heavily on these techniques, which are often computationally expensive. In…

Computer Vision and Pattern Recognition · Computer Science 2019-07-24 Adrian V. Dalca , Evan Yu , Polina Golland , Bruce Fischl , Mert R. Sabuncu , Juan Eugenio Iglesias

The claustrum is a band-like gray matter structure located between putamen and insula whose exact functions are still actively researched. Its sheet-like structure makes it barely visible in in vivo Magnetic Resonance Imaging (MRI) scans at…

Computer Vision and Pattern Recognition · Computer Science 2025-05-01 Chiara Mauri , Ryan Fritz , Jocelyn Mora , Benjamin Billot , Juan Eugenio Iglesias , Koen Van Leemput , Jean Augustinack , Douglas N Greve

Segmentation of magnetic resonance images (MRI) facilitates analysis of human brain development by delineating anatomical structures. However, in infants and young children, accurate segmentation is challenging due to development and…

Machine Learning · Computer Science 2026-04-01 Malte Hoffmann , Lilla Zöllei , Adrian V. Dalca

Multi-contrast MRI acquisitions of an anatomy enrich the magnitude of information available for diagnosis. Yet, excessive scan times associated with additional contrasts may be a limiting factor. Two mainstream approaches for enhanced scan…

Computer Vision and Pattern Recognition · Computer Science 2018-05-29 Salman Ul Hassan Dar , Mahmut Yurt , Mohammad Shahdloo , Muhammed Emrullah Ildız , Tolga Çukur

We introduce a strategy for learning image registration without acquired imaging data, producing powerful networks agnostic to contrast introduced by magnetic resonance imaging (MRI). While classical registration methods accurately estimate…

Image and Video Processing · Electrical Eng. & Systems 2022-03-04 Malte Hoffmann , Benjamin Billot , Douglas N. Greve , Juan Eugenio Iglesias , Bruce Fischl , Adrian V. Dalca

A large amount of manual segmentation is typically required to train a robust segmentation network so that it can segment objects of interest in a new imaging modality. The manual efforts can be alleviated if the manual segmentation in one…

Computer Vision and Pattern Recognition · Computer Science 2021-07-13 Bo Zhou , Chi Liu , James S. Duncan

Manual segmentation of medical images is labor intensive and especially challenging for images with poor contrast or resolution. The presence of disease exacerbates this further, increasing the need for an automated solution. To this…

Image and Video Processing · Electrical Eng. & Systems 2024-06-26 Selena Huisman , Matteo Maspero , Marielle Philippens , Joost Verhoeff , Szabolcs David

Learning-based synthetic multi-contrast MRI commonly involves deep models trained using high-quality images of source and target contrasts, regardless of whether source and target domain samples are paired or unpaired. This results in…

Image and Video Processing · Electrical Eng. & Systems 2021-05-13 Mahmut Yurt , Salman Ul Hassan Dar , Muzaffer Özbey , Berk Tınaz , Kader Karlı Oğuz , Tolga Çukur

A key limitation of deep convolutional neural networks (DCNN) based image segmentation methods is the lack of generalizability. Manually traced training images are typically required when segmenting organs in a new imaging modality or from…

Computer Vision and Pattern Recognition · Computer Science 2019-10-01 Yuankai Huo , Zhoubing Xu , Hyeonsoo Moon , Shunxing Bao , Albert Assad , Tamara K. Moyo , Michael R. Savona , Richard G. Abramson , Bennett A. Landman

Most existing algorithms for automatic 3D morphometry of human brain MRI scans are designed for data with near-isotropic voxels at approximately 1 mm resolution, and frequently have contrast constraints as well - typically requiring T1…

Image and Video Processing · Electrical Eng. & Systems 2020-12-25 Juan Eugenio Iglesias , Benjamin Billot , Yael Balbastre , Azadeh Tabari , John Conklin , Daniel C. Alexander , Polina Golland , Brian L. Edlow , Bruce Fischl

In our comprehensive experiments and evaluations, we show that it is possible to generate multiple contrast (even all synthetically) and use synthetically generated images to train an image segmentation engine. We showed promising…

Image and Video Processing · Electrical Eng. & Systems 2022-07-07 Ismail Irmakci , Zeki Emre Unel , Nazli Ikizler-Cinbis , Ulas Bagci

Magnetic resonance imaging (MRI) is an invaluable tool for clinical and research applications. Yet, variations in scanners and acquisition parameters cause inconsistencies in image contrast, hindering data comparability and reproducibility…

Image and Video Processing · Electrical Eng. & Systems 2025-09-09 Daniel Scholz , Ayhan Can Erdur , Robbie Holland , Viktoria Ehm , Jan C. Peeken , Benedikt Wiestler , Daniel Rueckert

A lack of generalizability is one key limitation of deep learning based segmentation. Typically, one manually labels new training images when segmenting organs in different imaging modalities or segmenting abnormal organs from distinct…

Computer Vision and Pattern Recognition · Computer Science 2017-12-22 Yuankai Huo , Zhoubing Xu , Shunxing Bao , Albert Assad , Richard G. Abramson , Bennett A. Landman

Segmentation of fetal brain tissue from magnetic resonance imaging (MRI) plays a crucial role in the study of in utero neurodevelopment. However, automated tools face substantial domain shift challenges as they must be robust to highly…

Image and Video Processing · Electrical Eng. & Systems 2024-10-15 Vladyslav Zalevskyi , Thomas Sanchez , Margaux Roulet , Jordina Aviles Verddera , Jana Hutter , Hamza Kebiri , Meritxell Bach Cuadra
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