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Backpropagation (BP) uses detailed, unit-specific feedback to train deep neural networks (DNNs) with remarkable success. That biological neural circuits appear to perform credit assignment, but cannot implement BP, implies the existence of…

Neurons and Cognition · Quantitative Biology 2021-11-01 David G. Clark , L. F. Abbott , SueYeon Chung

Training deep neural networks typically relies on backpropagating high dimensional error signals a computationally intensive process with little evidence supporting its implementation in the brain. However, since most tasks involve…

Machine Learning · Computer Science 2026-01-15 Maher Hanut , Jonathan Kadmon

The history of deep learning has shown that human-designed problem-specific networks can greatly improve the classification performance of general neural models. In most practical cases, however, choosing the optimal architecture for a…

Machine Learning · Computer Science 2020-09-14 Nicolo Colombo , Yang Gao

The success of deep learning sparked interest in whether the brain learns by using similar techniques for assigning credit to each synaptic weight for its contribution to the network output. However, the majority of current attempts at…

The backpropagation algorithm has experienced remarkable success in training large-scale artificial neural networks; however, its biological plausibility has been strongly criticized, and it remains an open question whether the brain…

Neural and Evolutionary Computing · Computer Science 2026-03-27 Bariscan Bozkurt , Cengiz Pehlevan , Alper T Erdogan

Back-propagation has been the workhorse of recent successes of deep learning but it relies on infinitesimal effects (partial derivatives) in order to perform credit assignment. This could become a serious issue as one considers deeper and…

Machine Learning · Computer Science 2015-11-26 Dong-Hyun Lee , Saizheng Zhang , Asja Fischer , Yoshua Bengio

Deep learning has achieved impressive prediction accuracies in a variety of scientific and industrial domains. However, the nested non-linear feature of deep learning makes the learning highly non-transparent, i.e., it is still unknown how…

Machine Learning · Computer Science 2020-10-26 Chan Li , Haiping Huang

The spectacular successes of recurrent neural network models where key parameters are adjusted via backpropagation-based gradient descent have inspired much thought as to how biological neuronal networks might solve the corresponding…

Neurons and Cognition · Quantitative Biology 2023-01-18 Yuhan Helena Liu , Stephen Smith , Stefan Mihalas , Eric Shea-Brown , Uygar Sümbül

In a physical neural system, learning rules must be local both in space and time. In order for learning to occur, non-local information must be communicated to the deep synapses through a communication channel, the deep learning channel. We…

Neural and Evolutionary Computing · Computer Science 2017-12-25 Pierre Baldi , Peter Sadowski , Zhiqin Lu

Neural networks trained with backpropagation, the standard algorithm of deep learning which uses weight transport, are easily fooled by existing gradient-based adversarial attacks. This class of attacks are based on certain small…

Machine Learning · Computer Science 2019-10-04 Mohamed Akrout

Deep neural networks have excelled on a wide range of problems, from vision to language and game playing. Neural networks very gradually incorporate information into weights as they process data, requiring very low learning rates. If the…

The Backpropagation algorithm relies on the abstraction of using a neural model that gets rid of the notion of time, since the input is mapped instantaneously to the output. In this paper, we claim that this abstraction of ignoring time,…

Machine Learning · Computer Science 2020-06-19 Alessandro Betti , Marco Gori

Current algorithms for deep learning probably cannot run in the brain because they rely on weight transport, where forward-path neurons transmit their synaptic weights to a feedback path, in a way that is likely impossible biologically. An…

Machine Learning · Computer Science 2020-01-13 Mohamed Akrout , Collin Wilson , Peter C. Humphreys , Timothy Lillicrap , Douglas Tweed

Despite its widespread use in neural networks, error backpropagation has faced criticism for its lack of biological plausibility, suffering from issues such as the backward locking problem and the weight transport problem. These limitations…

Machine Learning · Computer Science 2024-10-24 Chia-Hsiang Kao , Bharath Hariharan

Backpropagation is the cornerstone of deep learning, but its reliance on symmetric weight transport and global synchronization makes it computationally expensive and biologically implausible. Feedback alignment offers a promising…

Machine Learning · Computer Science 2025-05-28 Jeonghwan Cheon , Jaehyuk Bae , Se-Bum Paik

Predictive coding (PC) is a general theory of cortical function. The local, gradient-based learning rules found in one kind of PC model have recently been shown to closely approximate backpropagation. This finding suggests that this…

Neural and Evolutionary Computing · Computer Science 2021-12-09 Nick Alonso , Emre Neftci

Developing strong AI signifies the arrival of technological singularity, contributing greatly to advancing human civilization and resolving social issues. Neural networks (NNs) and deep learning, which utilize NNs, are expected to lead to…

Machine Learning · Computer Science 2024-09-09 Kei Itoh

Backpropagation is driving today's artificial neural networks (ANNs). However, despite extensive research, it remains unclear if the brain implements this algorithm. Among neuroscientists, reinforcement learning (RL) algorithms are often…

Neurons and Cognition · Quantitative Biology 2020-04-24 Benjamin James Lansdell , Prashanth Ravi Prakash , Konrad Paul Kording

The ubiquitous backpropagation algorithm requires sequential updates through the network introducing a locking problem. In addition, back-propagation relies on the transpose of forward weight matrices to compute updates, introducing a…

Machine Learning · Computer Science 2023-10-31 David Kappel , Khaleelulla Khan Nazeer , Cabrel Teguemne Fokam , Christian Mayr , Anand Subramoney

It is widely believed that the backpropagation algorithm is essential for learning good feature detectors in early layers of artificial neural networks, so that these detectors are useful for the task performed by the higher layers of that…

Machine Learning · Computer Science 2019-08-30 Dmitry Krotov , John Hopfield