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When conducting large scale inference, such as genome-wide association studies or image analysis, nominal $p$-values are often adjusted to improve control over the family-wise error rate (FWER). When the majority of tests are null,…

Methodology · Statistics 2017-07-20 Sarah Fletcher Mercaldo , Jeffrey D. Blume

The two-trials rule in drug regulation requires statistically significant results from two pivotal trials to demonstrate efficacy. However, it is unclear how the effect estimates from both trials should be combined to quantify the drug…

Methodology · Statistics 2025-07-08 Samuel Pawel , Małgorzata Roos , Leonhard Held

It is common for genomic data analysis to use $p$-values from a large number of permutation tests. The multiplicity of tests may require very tiny $p$-values in order to reject any null hypotheses and the common practice of using randomly…

Statistics Theory · Mathematics 2017-08-10 Hera Yu He , Kinjal Basu , Qingyuan Zhao , Art B. Owen

Replicability is a lynchpin for credible discoveries. The partial conjunction (PC) p-value, which combines individual base p-values from multiple similar studies, can gauge whether a feature of interest exhibits replicated signals across…

Methodology · Statistics 2025-07-29 Ninh Tran , Dennis Leung

The Fisher Information Matrix formalism is extended to cases where the data is divided into two parts (X,Y), where the expectation value of Y depends on X according to some theoretical model, and X and Y both have errors with arbitrary…

Cosmology and Nongalactic Astrophysics · Physics 2015-02-20 A. F. Heavens , M. Seikel , B. D. Nord , M. Aich , Y. Bouffanais , B. A. Bassett , M. P. Hobson

This article addresses issues of model criticism and model comparison in Bayesian contexts, and focusses on the use of the so-called posterior predictive p-values (ppp values). These involve a general discrepancy or conflict measure and…

Methodology · Statistics 2026-05-26 Nils Lid Hjort , Fredrik A. Dahl , Gunnhildur Högnadóttir Steinbakk

Testing effect size homogeneity is an essential part when conducting a meta-analysis. Comparative studies of effect size homogeneity tests in case of binary outcomes are found in the literature, but no test has come out as an absolute…

Methodology · Statistics 2022-03-11 Osama Almalik

In small sample studies with binary outcome data, use of a normal approximation for hypothesis testing can lead to substantial inflation of the type-I error-rate. Consequently, exact statistical methods are necessitated, and accordingly,…

Methodology · Statistics 2017-11-29 Michael Grayling , Adrian Mander , James Wason

Averaging the parameters of models that have the same architecture and initialization can provide a means of combining their respective capabilities. In this paper, we take the perspective that this "merging" operation can be seen as…

Machine Learning · Computer Science 2022-08-29 Michael Matena , Colin Raffel

Generative Adversarial Networks (GANs) are powerful models for learning complex distributions. Stable training of GANs has been addressed in many recent works which explore different metrics between distributions. In this paper we introduce…

Machine Learning · Computer Science 2017-11-07 Youssef Mroueh , Tom Sercu

We propose a versatile and computationally efficient estimating equation method for a class of hierarchical multiplicative generalized linear mixed models with additive dispersion components, based on explicit modelling of the covariance…

Methodology · Statistics 2010-08-18 René Holst , Bent Jørgensen

Fisher-matrix methods are widely used to predict how accurately parameters can be estimated. Being computationally efficient, this approach is prompted by the large number of signals simulated in forecast studies for future…

General Relativity and Quantum Cosmology · Physics 2026-04-14 Ulyana Dupletsa , Jan Harms , Ken K. Y. Ng , Jacopo Tissino , Filippo Santoliquido , Andrea Cozzumbo

Rerandomization discards assignments with covariates unbalanced in the treatment and control groups to improve estimation and inference efficiency. However, the acceptance-rejection sampling method used in rerandomization is computationally…

Methodology · Statistics 2022-06-28 Ke Zhu , Hanzhong Liu

A common approach to analyzing categorical correlated time series data is to fit a generalized linear model (GLM) with past data as covariate inputs. There remain challenges to conducting inference for short time series length. By treating…

Statistics Theory · Mathematics 2018-10-23 Xu Gao , Hernando Ombao , Daniel Gillen

The Fisher information matrix is a quantity of fundamental importance for information geometry and asymptotic statistics. In practice, it is widely used to quickly estimate the expected information available in a data set and guide…

Methodology · Statistics 2023-06-06 William R. Coulton , Benjamin D. Wandelt

This paper concerns the problem of applying the generalized goodness-of-fit (gGOF) type tests for analyzing correlated data. The gGOF family broadly covers the maximum-based testing procedures by ordered input $p$-values, such as the false…

Methodology · Statistics 2018-06-12 Hong Zhang , Zheyang Wu

We introduce a joint posterior $p$-value, an extension of the posterior predictive $p$-value for multiple test statistics, designed to address limitations of existing Bayesian $p$-values in the setting of continuous model expansion. In…

Methodology · Statistics 2023-12-13 Collin Cademartori

Permutation procedures are common practice in hypothesis testing when distributional assumptions about the test statistic are not met or unknown. With only few permutations, empirical p-values lie on a coarse grid and may even be zero when…

Re-sampling based statistical tests are known to be computationally heavy, but reliable when small sample sizes are available. Despite their nice theoretical properties not much effort has been put to make them efficient. In this paper we…

Methodology · Statistics 2018-06-29 Christina Chatzipantsiou , Marios Dimitriadis , Manos Papadakis , Michail Tsagris

In this paper, we derive new model formulations for computing generalized singular values of a Grassman matrix pair. These new formulations make use of truncated filter matrices to locate the $i$-th generalized singular value of a Grassman…

Numerical Analysis · Mathematics 2020-04-07 Wei-Wei Xu , Michael K. Ng , Zheng-Jian Bai