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Background: The recent explosion of experimental techniques in single molecule biophysics has generated a variety of novel time series data requiring equally novel computational tools for analysis and inference. This article describes in…

Quantitative Methods · Quantitative Biology 2010-09-07 Jonathan E. Bronson , Jake M. Hofman , Jingyi Fei , Ruben L. Gonzalez , Chris H. Wiggins

NI-fECG have emerged as alternative for fetal arrhythmia monitoring. But due to multi-signal waveform they are tough to understand and due to highly varying and complex nature traditional fiducial methods cannot be applied. Further, it has…

Signal Processing · Electrical Eng. & Systems 2025-01-29 Deva Satay Sriram Chintapenta , Aman Verma , Saikat Majumder

We develop a mathematical and numerical framework to solve state estimation problems for applications that present variations in the shape of the spatial domain. This situation arises typically in a biomedical context where inverse problems…

Numerical Analysis · Mathematics 2023-03-14 Felipe Galarce , Damiano Lombardi , Olga Mula

Reconstructing visual stimulus images is a significant task in neural decoding, and up to now, most studies consider the functional magnetic resonance imaging (fMRI) as the signal source. However, the fMRI-based image reconstruction methods…

Image and Video Processing · Electrical Eng. & Systems 2024-03-12 Hongguang Pan , Zhuoyi Li , Yunpeng Fu , Xuebin Qin , Jianchen Hu

Full-field vibration profilometry is essential for dynamic characterizing microelectromechanical systems (MEMS/MOEMS). Time-averaged interferometry (TAI) encodes spatial information about MEMS or MOEMS vibration amplitude in the…

Photomultiplier tubes (PMTs) are widely used in particle and nuclear physics experiments. The reconstruction of PMT waveforms is a fundamental task in these experiments, where accurate extraction of photoelectron (PE) multiplicities and…

High Energy Physics - Experiment · Physics 2026-05-29 Yiming Xu , Youwen Fan , Siyu Chen , Hongyue Duyang , Teng Li , Yaoguang Wang

Given the notably increasing complexity of mathematical models to study realistic systems and their coupling to their environment that constrains their dynamics, both analytical approaches and numerical methods that build on these models,…

Quantum Physics · Physics 2019-11-11 I. Luchnikov , A. Ryzhov , P. -J. C. Stas , S. N. Filippov , H. Ouerdane

Accurately predicting enzyme functionality remains one of the major challenges in computational biology, particularly for enzymes with limited structural annotations or sequence homology. We present a novel multimodal Quantum Machine…

Machine Learning · Computer Science 2025-08-21 Murat Isik , Mandeep Kaur Saggi , Humaira Gowher , Sabre Kais

Deconvolving COMPTEL gamma-ray data into images presents a major methodological challenge. We developed a new algorithm called Multiresolution Regularized Expectation Maximization (MREM), which explicitly accounts for spatial correlations…

This paper presents a novel approach for learned synergistic reconstruction of medical images using multibranch generative models. Leveraging variational autoencoders (VAEs), our model learns from pairs of images simultaneously, enabling…

Image and Video Processing · Electrical Eng. & Systems 2025-02-04 Noel Jeffrey Pinton , Alexandre Bousse , Catherine Cheze-Le-Rest , Dimitris Visvikis

This paper adapts a Multiple-Model Coding (MMC) approach for sampled electrical signal waveforms to satisfy reconstructed signal quality constraints. The baseline MMC approach consists of two stages processing vectors of Voltage and Current…

Signal Processing · Electrical Eng. & Systems 2025-11-14 Corentin Presvôts , Michel Kieffer , Thibault Prevost

The multifrequency electrical impedance tomography consists in retrieving the conductivity distribution of a sample by injecting a finite number of currents with multiple frequencies. In this paper we consider the case where the…

Numerical Analysis · Mathematics 2017-04-18 Habib Ammari , Faouzi Triki , Chun-Hsiang Tsou

This work is motivated by multimodality breast cancer imaging data, which is quite challenging in that the signals of discrete tumor-associated microvesicles (TMVs) are randomly distributed with heterogeneous patterns. This imposes a…

Machine Learning · Statistics 2019-03-22 Xiwei Tang , Xuan Bi , Annie Qu

Advancements in digital imaging technologies have sparked increased interest in using multiplexed immunofluorescence (mIF) images to visualise and identify the interactions between specific immunophenotypes with the tumour microenvironment…

Image and Video Processing · Electrical Eng. & Systems 2024-07-01 Piumi Sandarenu , Julia Chen , Iveta Slapetova , Lois Browne , Peter H. Graham , Alexander Swarbrick , Ewan K. A. Millar , Yang Song , Erik Meijering

Recovering high-frequency textures in image demosaicking remains a challenging issue. While existing methods introduced elaborate spatial learning methods, they still exhibit limited performance. To address this issue, a frequency…

Computer Vision and Pattern Recognition · Computer Science 2025-03-21 Jingyun Liu , Daiqin Yang , Zhenzhong Chen

Fluorescence molecular tomography (FMT) is an emerging powerful tool for biomedical research. There are two factors that influence FMT reconstruction most effectively. The first one is the regularization techniques. Traditional methods such…

Image and Video Processing · Electrical Eng. & Systems 2021-09-09 Yan Liu , Wuwei Ren , Habib Ammari

In a medium where the dielectric permittivity is perturbed in the presence of an acoustic wave, optical scattering generates frequency-shifted light. In this paper we consider the inverse problem of recovering the optical properties of this…

Analysis of PDEs · Mathematics 2019-10-14 Francis J. Chung , Jeremy G. Hoskins , John C. Schotland

Quantitative imaging methods, such as magnetic resonance fingerprinting (MRF), aim to extract interpretable pathology biomarkers by estimating biophysical tissue parameters from signal evolutions. However, the pattern-matching algorithms or…

Decoding human brain activities via functional magnetic resonance imaging (fMRI) has gained increasing attention in recent years. While encouraging results have been reported in brain states classification tasks, reconstructing the details…

Artificial Intelligence · Computer Science 2017-07-12 Changde Du , Changying Du , Huiguang He

Photomultiplier tubes (PMTs) are widely employed in particle and nuclear physics experiments. The accuracy of PMT waveform reconstruction directly impacts the detector's spatial and energy resolution. A key challenge arises when multiple…

High Energy Physics - Experiment · Physics 2026-02-06 Kainan Liu , Jingyu Huang , Guihong Huang , Jianyi Luo