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Recent theoretical work has demonstrated that Neighbor Joining applied to concatenated DNA sequences is a statistically consistent method of species tree reconstruction. This brief note compares the accuracy of this approach to other…

Populations and Evolution · Quantitative Biology 2016-12-07 Joseph Rusinko , Matthew McPartlon

This work considers the problem of learning the structure of multivariate linear tree models, which include a variety of directed tree graphical models with continuous, discrete, and mixed latent variables such as linear-Gaussian models,…

Machine Learning · Computer Science 2011-11-09 Animashree Anandkumar , Kamalika Chaudhuri , Daniel Hsu , Sham M. Kakade , Le Song , Tong Zhang

This paper introduces constNJ, the first algorithm for phylogenetic reconstruction of sets of trees with constrained pairwise rooted subtree-prune regraft (rSPR) distance. We are motivated by the problem of constructing sets of trees which…

Populations and Evolution · Quantitative Biology 2009-09-30 Frederick A. Matsen

Modeling the distribution of high dimensional data by a latent tree graphical model is a prevalent approach in multiple scientific domains. A common task is to infer the underlying tree structure, given only observations of its terminal…

Machine Learning · Statistics 2021-12-08 Yariv Aizenbud , Ariel Jaffe , Meng Wang , Amber Hu , Noah Amsel , Boaz Nadler , Joseph T. Chang , Yuval Kluger

The Neighbor-Joining algorithm is a recursive procedure for reconstructing trees that is based on a transformation of pairwise distances between leaves. We present a generalization of the neighbor-joining transformation, which uses…

Quantitative Methods · Quantitative Biology 2007-05-23 Dan Levy , Ruriko Yoshida , Lior Pachter

In 2007, Eickmeyer et al. showed that the tree topologies outputted by the Neighbor-Joining (NJ) algorithm and the balanced minimum evolution (BME) method for phylogenetic reconstruction are each determined by a polyhedral subdivision of…

Combinatorics · Mathematics 2009-08-04 Kord Eickmeyer , Ruriko Yoshida

In this article we propose a new method, which we name 'quartet neighbor joining', or 'quartet-NJ', to infer an unrooted species tree on a given set of taxa T from empirical distributions of unrooted quartet gene trees on all four-taxon…

Populations and Evolution · Quantitative Biology 2011-08-09 Martin Kreidl

The popular neighbor-joining (NJ) algorithm used in phylogenetics is a greedy algorithm for finding the balanced minimum evolution (BME) tree associated to a dissimilarity map. From this point of view, NJ is ``optimal'' when the algorithm…

Quantitative Methods · Quantitative Biology 2007-10-29 Kord Eickmeyer , Peter Huggins , Lior Pachter , Ruriko Yoshida

Latent variable models are an elegant framework for capturing rich probabilistic dependencies in many applications. However, current approaches typically parametrize these models using conditional probability tables, and learning relies…

Machine Learning · Computer Science 2012-10-19 Ankur P. Parikh , Le Song , Mariya Ishteva , Gabi Teodoru , Eric P. Xing

A central task in the study of molecular sequence data from present-day species is the reconstruction of the ancestral relationships. The most established approach to tree reconstruction is the maximum likelihood (ML) method. In this…

Quantitative Methods · Quantitative Biology 2007-05-23 Asger Hobolth , Ruriko Yoshida

A variety of algorithms have been proposed for reconstructing trees that show the evolutionary relationships between species by comparing differences in genetic data across present-day taxa. If the leaf-to-leaf distances in a tree can be…

Populations and Evolution · Quantitative Biology 2014-11-18 Olivier Gascuel , Mike Steel

The Neighbor-Joining algorithm is a popular distance-based phylogenetic method that computes a tree metric from a dissimilarity map arising from biological data. Realizing dissimilarity maps as points in Euclidean space, the algorithm…

Combinatorics · Mathematics 2020-09-18 Ruth Davidson , Abraham Martin del Campo

We study the problem of learning a latent tree graphical model where samples are available only from a subset of variables. We propose two consistent and computationally efficient algorithms for learning minimal latent trees, that is, trees…

Machine Learning · Statistics 2010-09-15 Myung Jin Choi , Vincent Y. F. Tan , Animashree Anandkumar , Alan S. Willsky

SpectralNet is a graph clustering method that uses neural network to find an embedding that separates the data. So far it was only used with $k$-nn graphs, which are usually constructed using a distance metric (e.g., Euclidean distance).…

Machine Learning · Computer Science 2023-02-28 Mashaan Alshammari , John Stavrakakis , Adel F. Ahmed , Masahiro Takatsuka

While Graph Neural Network (GNN) has shown superiority in learning node representations of homogeneous graphs, leveraging GNN on heterogeneous graphs remains a challenging problem. The dominating reason is that GNN learns node…

Social and Information Networks · Computer Science 2020-09-22 Ziyue Qiao , Pengyang Wang , Yanjie Fu , Yi Du , Pengfei Wang , Yuanchun Zhou

Graphical modeling is a widely used tool for analyzing conditional dependencies between variables and traditional methods may struggle to capture shared and distinct structures in multi-group or multi-condition settings. Joint graphical…

Methodology · Statistics 2025-03-10 Duong H. T. Vo , Nelofer Syed , Thomas Thorne

Distance-based approaches in phylogenetics such as Neighbor-Joining are a fast and popular approach for building trees. These methods take pairs of sequences from them construct a value that, in expectation, is additive under a stochastic…

Populations and Evolution · Quantitative Biology 2008-08-21 Mike Steel

We present an integrated approach for structure and parameter estimation in latent tree graphical models. Our overall approach follows a "divide-and-conquer" strategy that learns models over small groups of variables and iteratively merges…

Machine Learning · Computer Science 2019-12-19 Furong Huang , Niranjan U. N. , Ioakeim Perros , Robert Chen , Jimeng Sun , Anima Anandkumar

In this paper, we will analyze the behavior of the Neighbor Joining algorithm on five taxa and we will show that the partition of the sample (data) space for estimation of a tree topology with five taxa into subspaces, within each of which…

Combinatorics · Mathematics 2007-05-23 Kord Eickmeyer , Ruriko Yoshida

There is a large variety of machine learning methodologies that are based on the extraction of spectral geometric information from data. However, the implementations of many of these methods often depend on traditional eigensolvers, which…

Machine Learning · Computer Science 2023-10-03 Chenghui Li , Rishi Sonthalia , Nicolas Garcia Trillos
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