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Deep learning (DL) has drawn tremendous attention in object localization and recognition for both natural and medical images. U-Net segmentation models have demonstrated superior performance compared to conventional handcrafted…

Computer Vision and Pattern Recognition · Computer Science 2021-03-29 Sivaramakrishnan Rajaraman , Les Folio , Jane Dimperio , Philip Alderson , Sameer Antani

In this work, we address the connection between population density centers in urban areas, and the nature of human flows between such centers, in shaping the vulnerability to the onset of contagious diseases. A study of 163 cities, chosen…

Physics and Society · Physics 2021-02-02 Surendra Hazarie , David Soriano-Paños , Alex Arenas , Jesús Gómez-Gardeñes , Gourab Ghoshal

Mycobacterium tuberculosis infection can involve all immune system components and can result in different disease outcomes. The antibiotic TB drugs require strict adherence to prevent both disease relapse and mutation of drug- and…

Dynamical Systems · Mathematics 2021-12-16 Wenjing Zhang

Covid-19 has caused hundred of thousands of deaths and an economic damage amounting to trillions of dollars, creating a desire for the rapid development of vaccine. Once available, vaccine is gradually produced, evoking the question on how…

Populations and Evolution · Quantitative Biology 2020-06-30 Jens Grauer , Hartmut Löwen , Benno Liebchen

The monitoring, analysis and prediction of epidemic spread in the region require the construction of mathematical model, big data processing and visualization because the amount of population and the size of the region could be huge. One of…

Populations and Evolution · Quantitative Biology 2020-02-07 Sergey Kabanikhin , Olga Krivorotko , Aliya Takuadina , Darya Andornaya , Shuhua Zhang

The optimal allocation of vaccines to population subgroups over time is a challenging health care management problem. In the context of a pandemic, the interaction between vaccination policies adopted by multiple agents and the cooperation…

Optimization and Control · Mathematics 2021-09-22 David Rey , Ahmed W Hammad , Meead Saberi

Tuberculosis (TB) remains a global health threat, ranking among the leading causes of mortality worldwide. In this context, machine learning (ML) has emerged as a transformative force, providing innovative solutions to the complexities…

Specifying a proper input distribution is often a challenging task in simulation modeling. In practice, there may be multiple plausible distributions that can fit the input data reasonably well, especially when the data volume is not large.…

Methodology · Statistics 2019-03-15 Weiwei Fan , L. Jeff Hong , Xiaowei Zhang

Epidemics occur in all shapes and forms: infections propagating in our sparse sexual networks, rumours and diseases spreading through our much denser social interactions, or viruses circulating on the Internet. With the advent of large…

Physics and Society · Physics 2013-09-02 Laurent Hébert-Dufresne , Antoine Allard , Jean-Gabriel Young , Louis J. Dubé

End-stage renal disease patients face a complicated sociomedical situation and rely on various forms of infrastructure for life-sustaining treatment. Disruption of these infrastructures during disasters poses a major threat to their lives.…

Optimization and Control · Mathematics 2023-06-26 Chia-Fu Liu , Ali Mostafavi

An essential consideration in urban transit facility planning is service efficiency and accessibility. Previous research has shown that reducing the number of facilities along a route may increase efficiency but decrease accessibility.…

Optimization and Control · Mathematics 2022-10-25 Einar Gabbassov

Global strategies to contain a pandemic, such as social distancing and protective measures, are designed to reduce the overall transmission rate between individuals. Despite such measures, essential institutions, including hospitals,…

Populations and Evolution · Quantitative Biology 2022-09-07 Roberto Morán-Tovar , Henning Gruell , Florian Klein , Michael Lässig

Urban traffic congestion remains a persistent issue for cities worldwide. Recent macroscopic models have adopted a mathematically well-defined relation between network flow and density to characterize traffic states over an urban region.…

Optimization and Control · Mathematics 2024-02-09 Mostafa Ameli , Jean-Patrick Lebacque , Negin Alisoltani , Ludovic Leclercq

When facing an extreme stressor, such as the COVID-19 pandemic, healthcare systems typically respond reactively by creating surge capacity at facilities that are at or approaching their baseline capacity. However, creating individual…

Optimization and Control · Mathematics 2020-11-09 Felix Parker , Hamilton Sawczuk , Fardin Ganjkhanloo , Farzin Ahmadi , Kimia Ghobadi

Continuous-time birth-death-shift (BDS) processes are frequently used in stochastic modeling, with many applications in ecology and epidemiology. In particular, such processes can model evolutionary dynamics of transposable elements -…

Methodology · Statistics 2014-12-02 Jason Xu , Peter Guttorp , Midori Kato-Maeda , Vladimir N. Minin

This study presents a mathematical model for optimal vaccination strategies in interconnected metropolitan areas, considering commuting patterns. It is a compartmental model with a vaccination rate for each city, acting as a control…

Populations and Evolution · Quantitative Biology 2024-04-29 Lucas Machado Moschen , María Soledad Aronna

In this paper, we present a decision support framework for optimizing multiple aspects of vaccine distribution across a multitier cold chain network. We propose two multi-period optimization formulations within this framework: first to…

Physics and Society · Physics 2022-01-12 Shanmukhi Sripada , Ayush Jain , Prasanna Ramamoorthy , Varun Ramamohan

Frequent emergence of communicable diseases has been a major concern worldwide. Lack of sufficient resources to mitigate the disease-burden makes the situation even more challenging for lower-income countries. Hence, strategy development…

Populations and Evolution · Quantitative Biology 2023-02-03 Biplab Maity , Swarnendu Banerjee , Abhishek Senapati , Joydev Chattopadhyay

This article considers the minimization of the total number of infected individuals over the course of an epidemic in which the rate of infectious contacts can be reduced by time-dependent nonpharmaceutical interventions. The societal and…

Optimization and Control · Mathematics 2023-03-16 Tom Britton , Lasse Leskelä

Comparing outcomes across hospitals, often to identify underperforming hospitals, is a critical task in health services research. However, naive comparisons of average outcomes, such as surgery complication rates, can be misleading because…

Applications · Statistics 2021-02-16 Luke Keele , Eli Ben-Michael , Avi Feller , Rachel Kelz , Luke Miratrix