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Large numbers of radiographic images are available in knee radiology practices which could be used for training of deep learning models for diagnosis of knee abnormalities. However, those images do not typically contain readily available…

Image and Video Processing · Electrical Eng. & Systems 2023-09-07 Jikai Zhang , Carlos Santos , Christine Park , Maciej Mazurowski , Roy Colglazier

This paper addresses the challenge of localization of anatomical landmarks in knee X-ray images at different stages of osteoarthritis (OA). Landmark localization can be viewed as regression problem, where the landmark position is directly…

Computer Vision and Pattern Recognition · Computer Science 2019-09-10 Aleksei Tiulpin , Iaroslav Melekhov , Simo Saarakkala

In recent years the NHS has been having increased difficulty seeing all low-risk patients, this includes but not limited to suspected osteoarthritis (OA) patients. To help address the increased waiting lists and shortages of staff, we…

Computer Vision and Pattern Recognition · Computer Science 2023-04-27 Kai Armstrong , Lei Zhang , Yan Wen , Alexander P. Willmott , Paul Lee , Xujioing Ye

Joint replacement is the most common inpatient surgical treatment in the US. We investigate the clinical pathway optimization for knee replacement, which is a sequential decision process from onset to recovery. Based on episodic claims from…

Machine Learning · Computer Science 2019-06-05 Hao Lu , Mengdi Wang

Total knee arthroplasty (TKA) and total hip arthroplasty (THA) improve symptoms in end-stage osteoarthritis, yet long-term objective characterization of perioperative physical activity trajectories remains limited. We conducted a…

In Total Knee Replacement Arthroplasty (TKA), surgical robotics can provide image-guided navigation to fit implants with high precision. Its tracking approach highly relies on inserting bone pins into the bones tracked by the optical…

Signal Processing · Electrical Eng. & Systems 2024-03-12 Bangyu Lan , Momen Abayazid , Nico Verdonschot , Stefano Stramigioli , Kenan Niu

Background: Deep learning superresolution (SR) may enhance musculoskeletal MR image quality, but its diagnostic value in knee imaging at 7T is unclear. Objectives: To compare image quality and diagnostic performance of SR, low-resolution…

Image and Video Processing · Electrical Eng. & Systems 2026-01-07 Pinzhen Chen , Libo Xu , Boyang Pan , Jing Li , Yuting Wang , Ran Xiong , Xiaoli Gou , Long Qing , Wenjing Hou , Nan-jie Gong , Wei Chen

Introduction: Bone health disorders like osteoarthritis and osteoporosis pose major global health challenges, often leading to delayed diagnoses due to limited diagnostic tools. This study presents an AI-powered system that analyzes knee…

Conventional inclusion criteria used in osteoarthritis clinical trials are not very effective in selecting patients who would benefit from a therapy being tested. Typically majority of selected patients show no or limited disease…

Knee Osteoarthritis (OA) is a debilitating disease affecting over 250 million people worldwide. Currently, radiologists grade the severity of OA on an ordinal scale from zero to four using the Kellgren-Lawrence (KL) system. Recent studies…

Image and Video Processing · Electrical Eng. & Systems 2024-07-16 Niamh Belton , Misgina Tsighe Hagos , Aonghus Lawlor , Kathleen M. Curran

Background: MR-based subchondral bone effectively predicts knee osteoarthritis. However, its clinical application is limited by the cost and time of MR. Purpose: We aim to develop a novel distillation-learning-based method named SRRD for…

Image and Video Processing · Electrical Eng. & Systems 2023-07-12 Yuqi Hu , Xiangyu Zhao , Gaowei Qing , Kai Xie , Chenglei Liu , Lichi Zhang

The purposes of this study were to investigate: 1) the effect of placement of region-of-interest (ROI) for texture analysis of subchondral bone in knee radiographs, and 2) the ability of several texture descriptors to distinguish between…

Image and Video Processing · Electrical Eng. & Systems 2020-05-18 Neslihan Bayramoglu , Aleksei Tiulpin , Jukka Hirvasniemi , Miika T. Nieminen , Simo Saarakkala

Deep neural networks have been widely studied for predicting a medical condition, such as total knee replacement (TKR). It has shown that data of different modalities, such as imaging data, clinical variables and demographic information,…

Computer Vision and Pattern Recognition · Computer Science 2023-03-27 Xinwen Liu , Jing Wang , S. Kevin Zhou , Craig Engstrom , Shekhar S. Chandra

Knee Osteoarthritis (KOA) is a common musculoskeletal condition that significantly affects mobility and quality of life, particularly in elderly populations. However, training deep learning models for early KOA classification is often…

Image and Video Processing · Electrical Eng. & Systems 2025-01-17 Zhe Wang , Aladine Chetouani , Mohamed Jarraya , Yung Hsin Chen , Yuhua Ru , Fang Chen , Fabian Bauer , Liping Zhang , Didier Hans , Rachid Jennane

Knee osteoarthritis (KOA) diagnosis from radiographs remains challenging due to the subtle morphological details that standard deep learning models struggle to capture effectively. We propose a novel multimodal framework that combines…

Computer Vision and Pattern Recognition · Computer Science 2025-10-28 Marouane Tliba , Mohamed Amine Kerkouri , Yassine Nasser , Nour Aburaed , Aladine Chetouani , Ulas Bagci , Rachid Jennane

Background: Osteoporosis and osteopenia are often undiagnosed until fragility fractures occur. Dual-energy X-ray absorptiometry (DXA) is the reference standard for bone mineral density (BMD) assessment, but access remains limited. Knee…

Computer Vision and Pattern Recognition · Computer Science 2026-04-23 Zhaochen Li , Xinghao Yan , Runni Zhou , Xiaoyang Li , Chenjie Zhu , Gege Wang , Yu Shi , Lixin Zhang , Rongrong Fu , Liehao Yan , Yuan Chai

In the current study, our purpose is to evaluate the feasibility of applying deep learning (DL) enabled algorithms to quantify bilateral knee biomarkers in healthy controls scanned at 0.55T and compared with 3.0T. The current study assesses…

Computer Vision and Pattern Recognition · Computer Science 2023-10-27 Rupsa Bhattacharjee , Zehra Akkaya , Johanna Luitjens , Pan Su , Yang Yang , Valentina Pedoia , Sharmila Majumdar

Knee osteoarthritis (KOA) affects more than 600 million individuals globally and is associated with significant pain, functional impairment, and disability. While personalized multidisciplinary interventions have the potential to slow…

Artificial Intelligence · Computer Science 2025-11-26 Weizhi Liu , Xi Chen , Zekun Jiang , Liang Zhao , Kunyuan Jiang , Ruisi Tang , Li Wang , Mingke You , Hanyu Zhou , Hongyu Chen , Qiankun Xiong , Yong Nie , Kang Li , Jian Li

Chronic kidney disease (CKD) represents a slowly progressive disorder that can eventually require renal replacement therapy (RRT) including dialysis or renal transplantation. Early identification of patients who will require RRT (as much as…

Machine Learning · Computer Science 2022-09-07 Daniel Lopez-Martinez , Christina Chen , Ming-Jun Chen

Progression of hip osteoarthritis (hip OA) leads to pain and disability, likely leading to surgical treatment such as hip arthroplasty at the terminal stage. The severity of hip OA is often classified using the Crowe and Kellgren-Lawrence…