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We developed deep learning models for predicting Total Knee Replacement (TKR) need within various time horizons in knee osteoarthritis patients, with a novel capability: the models can perform TKR prediction using a single scan, and…

Image and Video Processing · Electrical Eng. & Systems 2025-03-31 Haresh Rengaraj Rajamohan , Richard Kijowski , Kyunghyun Cho , Cem M. Deniz

Knee osteoarthritis (OA) is one of the most widespread and burdensome health problems [1-4]. Total knee replacement (TKR) may be offered as treatment for end-stage knee OA. Nevertheless, TKR is an invasive procedure involving prosthesis…

Image and Video Processing · Electrical Eng. & Systems 2025-11-20 Zhisen Hu , Dominic Cullen , David S. Johnson , Aleksei Tiulpin , Timothy F. Cootes , Claudia Lindner

Accurate prediction of knee osteoarthritis (KOA) progression from structural MRI has a potential to enhance disease understanding and support clinical trials. Prior art focused on manually designed imaging biomarkers, which may not fully…

Image and Video Processing · Electrical Eng. & Systems 2024-08-07 Egor Panfilov , Simo Saarakkala , Miika T. Nieminen , Aleksei Tiulpin

The aim of this study was to investigate the influence of MRI and patient data on the prediction of knee osteoarthritis (OA) incidence using different deep learning architectures. Knee OA incidence within 24 months was predicted using the…

Medical Physics · Physics 2022-09-05 Anastasis Alexopoulos , Jukka Hirvasniemi , Nazli Tümer

Knee osteoarthritis (OA) is the most common musculoskeletal disease without a cure, and current treatment options are limited to symptomatic relief. Prediction of OA progression is a very challenging and timely issue, and it could, if…

Computer Vision and Pattern Recognition · Computer Science 2019-05-07 Aleksei Tiulpin , Stefan Klein , Sita M. A. Bierma-Zeinstra , Jérôme Thevenot , Esa Rahtu , Joyce van Meurs , Edwin H. G. Oei , Simo Saarakkala

Knee osteoarthritis (OA) is the most common musculoskeletal disease in the world. In primary healthcare, knee OA is diagnosed using clinical examination and radiographic assessment. Osteoarthritis Research Society International (OARSI)…

Image and Video Processing · Electrical Eng. & Systems 2019-07-19 Aleksei Tiulpin , Simo Saarakkala

Knee osteoarthritis (OA) is the most common musculoskeletal disorder. OA diagnosis is currently conducted by assessing symptoms and evaluating plain radiographs, but this process suffers from subjectivity. In this study, we present a new…

Computer Vision and Pattern Recognition · Computer Science 2017-10-31 Aleksei Tiulpin , Jérôme Thevenot , Esa Rahtu , Petri Lehenkari , Simo Saarakkala

A survival analysis model for predicting time-to-total knee replacement (TKR) was developed using features from medical images and clinical measurements. Supervised and self-supervised deep learning approaches were utilized to extract…

Image and Video Processing · Electrical Eng. & Systems 2024-11-19 Ozkan Cigdem , Shengjia Chen , Chaojie Zhang , Kyunghyun Cho , Richard Kijowski , Cem M. Deniz

Knee Osteoarthritis (OA) is a destructive joint disease identified by joint stiffness, pain, and functional disability concerning millions of lives across the globe. It is generally assessed by evaluating physical symptoms, medical history,…

Image and Video Processing · Electrical Eng. & Systems 2024-10-28 Rohit Kumar Jain , Prasen Kumar Sharma , Sibaji Gaj , Arijit Sur , Palash Ghosh

The assessment of knee osteoarthritis (KOA) severity on knee X-rays is a central criteria for the use of total knee arthroplasty. However, this assessment suffers from imprecise standards and a remarkably high inter-reader variability. An…

Diagnosing knee osteoarthritis (OA) early is crucial for managing symptoms and preventing further joint damage, ultimately improving patient outcomes and quality of life. In this paper, a bioimpedance-based diagnostic tool that combines…

Signal Processing · Electrical Eng. & Systems 2025-05-06 Jamal Al-Nabulsi , Mohammad Al-Sayed Ahmad , Baraa Hasaneiah , Fayhaa AlZoubi

Knee Osteoarthritis (KOA) is a highly prevalent chronic musculoskeletal condition with no currently available treatment. The manifestation of KOA is heterogeneous and prediction of its progression is challenging. Current literature suggests…

Image and Video Processing · Electrical Eng. & Systems 2023-07-04 Egor Panfilov , Simo Saarakkala , Miika T. Nieminen , Aleksei Tiulpin

A transformer-based deep learning model, MR-Transformer, was developed for total knee replacement (TKR) prediction using magnetic resonance imaging (MRI). The model incorporates the ImageNet pre-training and captures three-dimensional (3D)…

Image and Video Processing · Electrical Eng. & Systems 2024-05-07 Chaojie Zhang , Shengjia Chen , Ozkan Cigdem , Haresh Rengaraj Rajamohan , Kyunghyun Cho , Richard Kijowski , Cem M. Deniz

Knee osteoarthritis (KOA) is among the musculoskeletal disorders that considerably restrict joint mobility, cause severe chronic pain and impact negatively on quality life. It is one of the persistent health issues worldwide. Generally,…

Artificial Intelligence · Computer Science 2026-05-08 Dayam Nadeem , Neha , Safdar Mustafa , Adnan Alvi , Mohd Hussain

Osteoarthritis (OA) is the most common musculoskeletal disease, with knee OA (KOA) being one of the leading causes of disability and a significant economic burden. Predicting KOA progression is crucial for improving patient outcomes,…

Machine Learning · Computer Science 2025-04-09 Khanh Nguyen , Huy Hoang Nguyen , Egor Panfilov , Aleksei Tiulpin

Medical imaging plays a crucial role in assessing knee osteoarthritis (OA) risk by enabling early detection and disease monitoring. Recent machine learning methods have improved risk estimation (i.e., predicting the likelihood of disease…

Computer Vision and Pattern Recognition · Computer Science 2025-06-18 David Butler , Adrian Hilton , Gustavo Carneiro

Knee osteoarthritis (OA) is very common progressive and degenerative musculoskeletal disease worldwide creates a heavy burden on patients with reduced quality of life and also on society due to financial impact. Therefore, any attempt to…

Image and Video Processing · Electrical Eng. & Systems 2020-05-26 Neslihan Bayramoglu , Miika T. Nieminen , Simo Saarakkala

Knee osteoarthritis (OA) is a common degenerate joint disorder that affects a large population of elderly people worldwide. Accurate radiographic assessment of knee OA severity plays a critical role in chronic patient management. Current…

Image and Video Processing · Electrical Eng. & Systems 2021-12-20 Kang Zheng , Yirui Wang , Chen-I Hsieh , Le Lu , Jing Xiao , Chang-Fu Kuo , Shun Miao

This paper proposes a new approach to automatically quantify the severity of knee osteoarthritis (OA) from radiographs using deep convolutional neural networks (CNN). Clinically, knee OA severity is assessed using Kellgren \& Lawrence (KL)…

Computer Vision and Pattern Recognition · Computer Science 2016-09-09 Joseph Antony , Kevin McGuinness , Noel E O Connor , Kieran Moran

Knee Osteoarthritis (KOA) is a prevalent musculoskeletal disorder that severely impacts mobility and quality of life, particularly among older adults. Its diagnosis often relies on subjective assessments using the Kellgren-Lawrence (KL)…

Image and Video Processing · Electrical Eng. & Systems 2025-01-17 Zhe Wang , Aladine Chetouani , Yung Hsin Chen , Yuhua Ru , Fang Chen , Mohamed Jarraya , Fabian Bauer , Liping Zhang , Didier Hans , Rachid Jennane
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