Related papers: Impact of chronic fetal hypoxia and inflammation o…
Background: Obstructive sleep apnea syndrome (OSAS) during pregnancy is common and can negatively affect fetal outcomes. However, studies on the immediate effects of maternal hypoxia on fetal heart rate (FHR) changes are lacking. Methods:…
Fetal oxygen delivery and consumption and blood gases in relation to gestational age. Oxygen crosses the placenta by diffusion and placental permeability to O$_2$ is high. Thus, the fetus receives adequate amounts, but vascular Po$_2$ is…
What is the influence of chronic maternal prenatal stress (PS) on fetal iron homeostasis? In a prospective case-control study in 164 pregnant women, we show that cord blood transferrin saturation is lower in male stressed neonates. The…
It has been found that the effect of childhood trauma (CT) exposure may pass on to the next generation. Scientists have hypothesized that the association between CT exposure and placental-fetal stress physiology is the mechanism. A study…
Adverse conditions in early life can have consequential impacts on individuals' health in older age. In one of the first papers on this topic, Barker and Osmond 1986 show a strong positive relationship between infant mortality rates in the…
As a solution to methodologic challenges inherent to estimating causal effects of exposures in early pregnancy, we suggest emulating a target trial using a treatment decision design, wherein time zero is centered around clinical landmarks…
Perinatal epidemiology often aims to evaluate exposures on infant outcomes. When the exposure affects the composition of people who give birth to live infants (e.g., by affecting fertility, behavior, or birth outcomes), this "live birth…
In this work, we investigated the effect of varying strength of Hyperkalemia and Hypoxia, in human cardiac tissue with a local ischemic subregion, on the electrical and mechanical activity of healthy and ischemic zones of the cardiac…
Hypertensive disorders of pregnancy occur in about 10% of pregnant women around the world. Though there is evidence that hypertension impacts maternal cardiac functions, the relation between hypertension and cardiac dysfunctions is only…
Infants born before 37 weeks of pregnancy are considered to be preterm. Typically, preterm infants have to be strictly monitored since they are highly susceptible to health problems like hypoxemia (low blood oxygen level), apnea,…
Psychosocial stress during pregnancy is a known contributor to preterm birth, but also has been increasingly appreciated as an in utero insult acting long-term on prenatal and postnatal neurodevelopmental trajectories. These events impact…
Objectives: A conflicting body of evidence suggests localized periodontal inflammation to spread systemically during pregnancy inducing adverse pregnancy outcomes. This systematic review and meta-analysis aimed to specifically evaluate the…
We present a novel computerized fetal heart rate intrapartum algorithm for early and individualized prediction of fetal cardiovascular decompensation, a key event in the causal chain leading to brain injury. This real-time machine learning…
Objective: We hypothesized that prenatal stress (PS) exerts lasting impact on fetal heart rate (fHR). We sought to validate the presence of such PS signature in fHR by measuring coupling between maternal HR (mHR) and fHR. Study design:…
Maternal obesity is associated with increased risk of diabetes, cardiovascular disease and hypertension in adult offspring. Midlife hypercholesterolemia and hypertension are risk factors for Alzheimer's disease, suggesting that the ageing…
In utero diffusion MRI provides unique opportunities to non-invasively study the microstructure of tissue during fetal development. A wide range of developmental processes, such as the growth of white matter tracts in the brain, the…
We analyzed the heartbeat time series of 12 human subjects exposed to progressive central hypovolemia with lower body negative pressure. Two data processing techniques based on wavelet transforms were used to determine the change in the…
Infarction- or ischaemia-induced cardiac fibrosis can be arrythmogenic. We use mathematcal models for diffuse fibrosis ($\mathcal{DF}$), interstitial fibrosis ($\mathcal{IF}$), patchy fibrosis ($\mathcal{PF}$), and compact fibrosis…
Cardiotocography (CTG) is a low-cost, non-invasive fetal health assessment technique used globally, especially in underdeveloped countries. However, it is currently mainly used to identify the fetus's current status (e.g., fetal acidosis or…
Introduction: Circadian rhythm disruption has garnered significant attention for its adverse effects on human health, particularly in reproductive medicine and fetal well-being. Assessing pregnancy health often relies on diagnostic markers…