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Brain networks from functional MRI have advanced our understanding of cortical activity and its disruption in neurodegenerative disorders. Recent work has increasingly focused on dynamic (time-varying) brain networks that capture both…
We introduce a wide and deep neural network for prediction of progression from patients with mild cognitive impairment to Alzheimer's disease. Information from anatomical shape and tabular clinical data (demographics, biomarkers) are fused…
Mild cognitive impairment(MCI) is a precursor of Alzheimer's disease(AD), and the detection of MCI is of great clinical significance. Analyzing the structural brain networks of patients is vital for the recognition of MCI. However, the…
Increasing effort in brain image analysis has been dedicated to early diagnosis of Alzheimer's disease (AD) based on neuroimaging data. Most existing studies have been focusing on binary classification problems, e.g., distinguishing AD…
Accurate diagnosis of Alzheimer's Disease (AD) entails clinical evaluation of multiple cognition metrics and biomarkers. Metrics such as the Alzheimer's Disease Assessment Scale - Cognitive test (ADAS-cog) comprise multiple subscores that…
Currently, the diagnosis of Alzheimer's disease is a complex and error-prone process. Improving this diagnosis could allow earlier detection of the disease and improve the quality of life of patients and their families. For this work, we…
Alzheimer's Disease (AD) is a severe brain disorder, destroying memories and brain functions. AD causes chronically, progressively, and irreversibly cognitive declination and brain damages. The reliable and effective evaluation of early…
Prediction of the cognitive evolution of a person susceptible to develop a neurodegenerative disorder is crucial to provide an appropriate treatment as soon as possible. In this paper we propose a 3D siamese network designed to extract…
Predicting whether subjects with mild cognitive impairment (MCI) will convert to Alzheimer's disease is a significant clinical challenge. Longitudinal variations and complementary information inherent in longitudinal and multimodal data are…
Alzheimer's Disease (AD) is one of the most concerned neurodegenerative diseases. In the last decade, studies on AD diagnosis attached great significance to artificial intelligence (AI)-based diagnostic algorithms. Among the diverse…
Objectives: The objectives of this narrative review are to summarize the current state of AI applications in neuroimaging for early Alzheimer's disease (AD) prediction and to highlight the potential of AI techniques in improving early AD…
Alzheimer's disease (AD) is the most prevalent neurodegenerative disorder, primarily affecting the elderly population and leading to significant cognitive decline. This decline manifests in various mental faculties such as attention,…
It is acknowledged that the most common cause of dementia worldwide is Alzheimer's disease (AD). This condition progresses in severity from mild to severe and interferes with people's everyday routines. Early diagnosis plays a critical role…
Pre-symptomatic (or Preclinical) Alzheimer's Disease is defined by biomarker evidence of fibrillar amyloid beta pathology in the absence of clinical symptoms. Clinical trials in this early phase of disease are challenging due to the slow…
Accurate modeling of cognitive decline in Alzheimer's disease is essential for early stratification and personalized management. While tabular predictors provide robust markers of global risk, their ability to capture subtle brain changes…
Most approaches to machine learning from electronic health data can only predict a single endpoint. Here, we present an alternative that uses unsupervised deep learning to simulate detailed patient trajectories. We use data comprising…
INTRODUCTION: Advanced machine learning methods might help to identify dementia risk from neuroimaging, but their accuracy to date is unclear. METHODS: We systematically reviewed the literature, 2006 to late 2016, for machine learning…
Deep learning methods based on Convolutional Neural Networks (CNNs) have shown great potential to improve early and accurate diagnosis of Alzheimer's disease (AD) dementia based on imaging data. However, these methods have yet to be widely…
Alzheimer's disease (AD) is one of the most prevalent neurodegenerative disorders worldwide. As it progresses, it leads to the deterioration of cognitive functions. Since AD is irreversible, early diagnosis is crucial for managing its…
In the last decade, computer-aided early diagnostics of Alzheimer's Disease (AD) and its prodromal form, Mild Cognitive Impairment (MCI), has been the subject of extensive research. Some recent studies have shown promising results in the AD…