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A macroscopic model to describe the dynamics of ion transport in ion channels is the Poisson-Nernst-Planck(PNP) equations. In this paper, we develop a finite-difference method for solving PNP equations, which is second-order accurate in…

Numerical Analysis · Mathematics 2013-03-18 Allen Flavell , Michael Machen , Bob Eisenberg , Chun Liu , Xiaofan Li

In this paper, we propose and analyze a second order accurate (in both time and space) numerical scheme for the Poisson-Nernst-Planck-Navier-Stokes system, which describes the ion electro-diffusion in fluids. In particular, the…

Numerical Analysis · Mathematics 2025-03-12 Yuzhe Qin , Cheng Wang

In this paper, we introduce and analyze a class of numerical schemes that demonstrate remarkable superiority in terms of efficiency, the preservation of positivity, energy stability, and high-order precision to solve the time-dependent…

Numerical Analysis · Mathematics 2025-07-01 Waixiang Cao , Yuzhe Qin , Minqiang Xu

First-order energy dissipative schemes in time are available in literature for the Poisson-Nernst-Planck (PNP) equations, but second-order ones are still in lack. This work proposes novel second-order discretization in time and finite…

Numerical Analysis · Mathematics 2023-09-08 Jie Ding , Shenggao Zhou

The Poisson-Nernst-Planck (PNP) equations are fundamental for modeling ion transport in electrochemical systems, capturing the intricate interplay of concentration gradients, electric fields, and ion fluxes essential for applications such…

Chemical Physics · Physics 2025-01-13 Yitao He , Dan Zhao

The Poisson--Nernst--Planck (PNP) equations have been widely applied to describe ionic transport in ion channels, nanofluidic devices, and many electrochemical systems. Despite their wide applications, the PNP equations fail in predicting…

Statistical Mechanics · Physics 2018-01-03 Farjana Siddiqua , Zhongming Wang , Shenggao Zhou

The Poisson-Nernst-Planck (PNP) system is a widely accepted model for simulation of ionic channels. In this paper, we design, analyze, and numerically validate a second order unconditional positivity-preserving scheme for solving a reduced…

Numerical Analysis · Mathematics 2019-10-01 Hailiang Liu , Wumaier Maimaitiyiming

We have developed efficient numerical algorithms for solving 3D steady-state Poisson-Nernst-Planck (PNP) equations with excess chemical potentials described by the classical density functional theory (cDFT). The coupled PNP equations are…

Numerical Analysis · Mathematics 2016-08-24 Da Meng , Bin Zheng , Guang Lin , Maria L. Sushko

A dynamic mass-transport method is proposed for approximately solving the Poisson-Nernst-Planck(PNP) equations. The semi-discrete scheme based on the JKO type variational formulation naturally enforces solution positivity and the energy law…

Numerical Analysis · Mathematics 2022-11-23 H. Liu , W. Maimaitiyiming

A finite element discretization using a method of lines approached is proposed for approximately solving the Poisson-Nernst-Planck (PNP) equations. This discretization scheme enforces positivity of the computed solutions, corresponding to…

Numerical Analysis · Mathematics 2015-03-17 Chun Liu , Maximilian Metti , Jinchao Xu

In this paper, we design, analyze, and numerically validate positive and energy-dissipating schemes for solving the time-dependent multi-dimensional system of Poisson-Nernst-Planck (PNP) equations, which has found much use in the modeling…

Numerical Analysis · Mathematics 2020-02-24 Hailiang Liu , Wumaier Maimaitiyiming

Effective Poisson-Nernst-Planck (PNP) equations are derived for macroscopic ion transport in charged porous media under periodic fluid flow by an asymptotic multi-scale expansion with drift. The microscopic setting is a two-component…

Mathematical Physics · Physics 2014-07-16 Markus Schmuck , Martin Z. Bazant

We consider in this paper a numerical approximation of Poisson-Nernst-Planck-Navier- Stokes (PNP-NS) system. We construct a decoupled semi-discrete and fully discrete scheme that enjoys the properties of positivity preserving, mass…

Numerical Analysis · Mathematics 2025-07-15 Ziyao Yu , Qing Cheng , Jie Shen , Changyou Wang

The analysis of structure-preserving numerical methods for the Poisson--Nernst--Planck (PNP) system has attracted growing interests in recent years. In this work, we provide an optimal rate convergence analysis and error estimate for finite…

Numerical Analysis · Mathematics 2022-02-23 Jie Ding , Cheng Wang , Shenggao Zhou

A second order accurate (in time) numerical scheme is proposed and analyzed for the Poisson-Nernst-Planck equation (PNP) system, reformulated as a non-constant mobility $H^{-1}$ gradient flow in the Energetic Variational Approach (EnVarA).…

Numerical Analysis · Mathematics 2022-08-15 Chun Liu , Cheng Wang , Steven M. Wise , Xingye Yue , Shenggao Zhou

In order to describe the dynamics of crowded ions (charged particles), we use an energetic variation approach to derive a modified Poisson-Nernst-Planck (PNP) system which includes an extra dissipation due to the effective velocity…

Mathematical Physics · Physics 2014-08-01 Chia-Yu Hsieh , YunKyong Hyon , Hijin Lee , Tai-Chia Lin , Chun Liu

We propose a modified Poisson-Nernst-Planck (PNP) model to investigate charge transport in electrolytes of inhomogeneous dielectric environment. The model includes the ionic polarization due to the dielectric inhomogeneity and the ion-ion…

Computational Physics · Physics 2015-06-19 Zhenli Xu , Manman Ma , Pei Liu

The Poisson-Nernst-Planck (PNP) system is a standard model for describing ion transport. In many applications, e.g., ions in biological tissues, the presence of thin boundary layers poses both modelling and computational challenges. In a…

Biological Physics · Physics 2018-06-22 Zilong Song , Xiulei Cao , Huaxiong Huang

The molecular mechanism of ion channel gating and substrate modulation is elusive for many voltage gated ion channels, such as eukaryotic sodium ones. The understanding of channel functions is a pressing issue in molecular biophysics and…

Biomolecules · Quantitative Biology 2016-11-15 Duan Chen , Guowei Wei

An integral equation method is presented for the 1D steady-state Poisson-Nernst-Planck equations modeling ion transport through membrane channels. The differential equations are recast as integral equations using Green's 3rd identity…

Numerical Analysis · Mathematics 2023-04-11 Zhen Chao , Weihua Geng , Robert Krasny
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