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Purpose: To apply tracer kinetic models as temporal constraints during reconstruction of under-sampled dynamic contrast enhanced (DCE) MRI. Methods: A library of concentration v.s time profiles is simulated for a range of physiological…

Dynamic contrast-enhanced (DCE) MRI is essential for breast cancer diagnosis and treatment. However, its reliance on contrast agents introduces safety concerns, contraindications, increased cost, and workflow complexity. To this end, we…

Image and Video Processing · Electrical Eng. & Systems 2025-09-16 Sebastian Ibarra , Javier del Riego , Alessandro Catanese , Julian Cuba , Julian Cardona , Nataly Leon , Jonathan Infante , Karim Lekadir , Oliver Diaz , Richard Osuala

Dynamic MRI reconstruction from undersampled measurements is a challenging inverse problem that requires preserving both spatial reconstruction quality and temporal consistency across the frames of the cine series. While recent…

Image and Video Processing · Electrical Eng. & Systems 2026-05-19 Yongliang Sun , Siddhant Gautam , Chaoyan Huang , Nicole Seiberlich , Ismail Alkhouri , Saiprasad Ravishankar

We propose a new computer aided detection framework for tumours acquired on DCE-MRI (Dynamic Contrast Enhanced Magnetic Resonance Imaging) series on small animals. In this approach we consider DCE-MRI series as multivariate images. A full…

Image and Video Processing · Electrical Eng. & Systems 2019-10-29 Guillaume Noyel , Jesus Angulo , Dominique Jeulin , Daniel Balvay , Charles-André Cuenod

Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) is a minimally invasive imaging technique which can be used for characterizing tumor biology and tumor response to radiotherapy. Pharmacokinetic (PK) estimation is widely used…

Image and Video Processing · Electrical Eng. & Systems 2018-03-06 Xia Zhu , Dipanjan Sengupta , Andrew Beers , Kalpathy-Cramer Jayashree , Theodore L. Willke

Elasticity image, visualizing the quantitative map of tissue stiffness, can be reconstructed by solving an inverse problem. Classical methods for magnetic resonance elastography (MRE) try to solve a regularized optimization problem…

Image and Video Processing · Electrical Eng. & Systems 2021-05-28 Narges Mohammadi , Marvin M. Doyley , Mujdat Cetin

Magnetic Resonance Imaging (MRI) offers unparalleled soft-tissue contrast but is fundamentally limited by long acquisition times. While deep learning-based accelerated MRI can dramatically shorten scan times, the reconstruction from…

Image and Video Processing · Electrical Eng. & Systems 2025-08-22 Paul Fischer , Jan Nikolas Morshuis , Thomas Küstner , Christian Baumgartner

Purpose: To develop a framework to reconstruct large-scale volumetric dynamic MRI from rapid continuous and non-gated acquisitions, with applications to pulmonary and dynamic contrast enhanced (DCE) imaging. Theory and Methods: The problem…

The goal of dynamic magnetic resonance imaging (dynamic MRI) is to visualize tissue properties and their local changes over time that are traceable in the MR signal. We propose a new variational approach for the reconstruction of subsampled…

Purpose: To introduce a novel deep learning based approach for fast and high-quality dynamic multi-coil MR reconstruction by learning a complementary time-frequency domain network that exploits spatio-temporal correlations simultaneously…

Image and Video Processing · Electrical Eng. & Systems 2021-06-21 Chen Qin , Jinming Duan , Kerstin Hammernik , Jo Schlemper , Thomas Küstner , René Botnar , Claudia Prieto , Anthony N. Price , Joseph V. Hajnal , Daniel Rueckert

This paper presents a method for virtual contrast enhancement in breast MRI, offering a promising non-invasive alternative to traditional contrast agent-based DCE-MRI acquisition. Using a conditional generative adversarial network, we…

Image and Video Processing · Electrical Eng. & Systems 2025-05-15 Richard Osuala , Smriti Joshi , Apostolia Tsirikoglou , Lidia Garrucho , Walter H. L. Pinaya , Daniel M. Lang , Julia A. Schnabel , Oliver Diaz , Karim Lekadir

We propose a novel deformation corrected compressed sensing (DC-CS) framework to recover dynamic magnetic resonance images from undersampled measurements. We introduce a generalized formulation that is capable of handling a wide class of…

Computer Vision and Pattern Recognition · Computer Science 2014-09-04 Sajan Goud Lingala , Edward DiBella , Mathews Jacob

Tumor vascularity detection and quantification are of high relevance in the assessment of cancer lesions not only for disease diagnostics but for therapy considerations and monitoring. The present work addressed the quantification of…

Medical Physics · Physics 2023-05-23 Jhonalbert Aponte , Álvaro Ruiz , Jacksson Sánchez , Miguel Martín-Landrove

Introduction: Quantification of dynamic contrast-enhanced (DCE)-MRI has the potential to provide valuable clinical information, but robust pharmacokinetic modeling remains a challenge for clinical adoption. Methods: A 7-layer neural network…

Medical Physics · Physics 2024-05-22 Ouri Cohen , Soudabeh Kargar , Sungmin Woo , Alberto Vargas , Ricardo Otazo

Magnetic resonance imaging (MRI) exam protocols consist of multiple contrast-weighted images of the same anatomy to emphasize different tissue properties. Due to the long acquisition times required to collect fully sampled k-space…

Image and Video Processing · Electrical Eng. & Systems 2023-06-08 Brett Levac , Ajil Jalal , Kannan Ramchandran , Jonathan I. Tamir

Dynamic Contrast Enhanced-Magnetic Resonance Imaging (DCE-MRI) is widely used to complement ultrasound examinations and x-ray mammography during the early detection and diagnosis of breast cancer. However, images generated by various MRI…

Image and Video Processing · Electrical Eng. & Systems 2021-06-18 Gourav Modanwal , Adithya Vellal , Maciej A. Mazurowski

Cardiac magnetic resonance imaging is a valuable non-invasive tool for identifying cardiovascular diseases. For instance, Cine MRI is the benchmark modality for assessing the cardiac function and anatomy. On the other hand, multi-contrast…

Image and Video Processing · Electrical Eng. & Systems 2023-10-11 George Yiasemis , Nikita Moriakov , Jan-Jakob Sonke , Jonas Teuwen

Dynamic Magnetic Resonance Imaging (MRI) is a crucial non-invasive method used to capture the movement of internal organs and tissues, making it a key tool for medical diagnosis. However, dynamic MRI faces a major challenge: long…

Image and Video Processing · Electrical Eng. & Systems 2024-09-20 Tamir Shor , Chaim Baskin , Alex Bronstein

Variational regularization of ill-posed inverse problems is based on minimizing the sum of a data fidelity term and a regularization term. The balance between them is tuned using a positive regularization parameter, whose automatic choice…

Numerical Analysis · Mathematics 2025-11-12 Markus Juvonen , Bjørn Jensen , Ilmari Pohjola , Yiqiu Dong , Samuli Siltanen

The choice of the parameter value for regularized inverse problems is critical to the results and remains a topic of interest. This article explores a criterion for selecting a good parameter value by maximizing the probability of the data,…

Numerical Analysis · Mathematics 2020-02-11 Toby Sanders , Rodrigo B. Platte , Robert D. Skeel