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A tractogram is a virtual representation of the brain white matter. It is composed of millions of virtual fibers, encoded as 3D polylines, which approximate the white matter axonal pathways. To date, tractograms are the most accurate white…

Computer Vision and Pattern Recognition · Computer Science 2022-12-08 Pietro Astolfi , Ruben Verhagen , Laurent Petit , Emanuele Olivetti , Silvio Sarubbo , Jonathan Masci , Davide Boscaini , Paolo Avesani

Cytoarchitectonic maps provide microstructural reference parcellations of the brain, describing its organization in terms of the spatial arrangement of neuronal cell bodies as measured from histological tissue sections. Recent work provided…

Image and Video Processing · Electrical Eng. & Systems 2021-06-02 Christian Schiffer , Katrin Amunts , Stefan Harmeling , Timo Dickscheid

The claustrum (Cl) is a thin grey matter structure located in the center of each brain hemisphere. Cl has been hypothesized as a central hub of the brain for multisensory/sensorimotor integration, consciousness, and attention. Accumulating…

Quantitative Methods · Quantitative Biology 2020-10-14 Seung Suk Kang , Joseph Bodenheimer , Tracey Butler

Segmentation of sub-cortical structures from MRI scans is of interest in many neurological diagnosis. Since this is a laborious task machine learning and specifically deep learning (DL) methods have become explored. The structural…

Image and Video Processing · Electrical Eng. & Systems 2021-11-11 Jayanthi Sivaswamy , Alphin J Thottupattu , Mythri V , Raghav Mehta , R Sheelakumari , Chandrasekharan Kesavadas

Many fields, such as neuroscience, are experiencing the vast proliferation of cellular data, underscoring the need for organizing and interpreting large datasets. A popular approach partitions data into manageable subsets via hierarchical…

Quantitative Methods · Quantitative Biology 2024-03-07 Diek W. Wheeler , Giorgio A. Ascoli

This work considers a continuous framework to characterize the population-level variability of structural connectivity. Our framework assumes the observed white matter fiber tract endpoints are driven by a latent random function defined…

Computation · Statistics 2022-07-19 William Consagra , Martin Cole , Zhengwu Zhang

Federated learning and its application to medical image segmentation have recently become a popular research topic. This training paradigm suffers from statistical heterogeneity between participating institutions' local datasets, incurring…

Image and Video Processing · Electrical Eng. & Systems 2023-10-19 Matthis Manthe , Stefan Duffner , Carole Lartizien

Cortical thickness measurements from magnetic resonance imaging, an important biomarker in many neurodegenerative and neurological disorders, are derived by many tools from an initial voxel-wise tissue segmentation. White matter (WM)…

Image and Video Processing · Electrical Eng. & Systems 2025-03-27 Vinzenz Uhr , Ivan Diaz , Christian Rummel , Richard McKinley

Multiple Sclerosis (MS) is an autoimmune disease that leads to lesions in the central nervous system. Magnetic resonance (MR) images provide sufficient imaging contrast to visualize and detect lesions, particularly those in the white…

Computer Vision and Pattern Recognition · Computer Science 2018-03-28 Snehashis Roy , John A. Butman , Daniel S. Reich , Peter A. Calabresi , Dzung L. Pham

A prominent goal of neuroimaging studies is mapping the human brain, in order to identify and delineate functionally-meaningful regions and elucidate their roles in cognitive behaviors. These brain regions are typically represented by…

Human-Computer Interaction · Computer Science 2020-09-04 Roza G. Bayrak , Nhung Hoang , Colin B. Hansen , Catie Chang , Matthew Berger

The thalamus consists of several histologically and functionally distinct nuclei increasingly implicated in brain pathology and important for treatment, motivating the need for development of fast and accurate thalamic segmentation. The…

Image and Video Processing · Electrical Eng. & Systems 2019-12-19 Charles Iglehart , Martin Monti , Joshua Cain , Thomas Tourdias , Manojkumar Saranathan

Medical image segmentation has become an essential technique in clinical and research-oriented applications. Because manual segmentation methods are tedious, and fully automatic segmentation lacks the flexibility of human intervention or…

Image and Video Processing · Electrical Eng. & Systems 2019-04-24 Kevin Karsch , Qing He , Ye Duan

Cranial nerves (CNs) play a crucial role in various essential functions of the human brain, and mapping their pathways from diffusion MRI (dMRI) provides valuable preoperative insights into the spatial relationships between individual CNs…

Computer Vision and Pattern Recognition · Computer Science 2025-08-01 Lei Xie , Jiahao Huang , Jiawei Zhang , Jianzhong He , Yiang Pan , Guoqiang Xie , Mengjun Li , Qingrun Zeng , Mingchu Li , Yuanjing Feng

High-throughput methods for yielding the set of connections in a neural system, the connectome, are now being developed. This tutorial describes ways to analyze the topological and spatial organization of the connectome at the macroscopic…

Neurons and Cognition · Quantitative Biology 2011-12-23 Marcus Kaiser

This paper presents a method that improve state-of-the-art of the concave point detection methods as a first step to segment overlapping objects on images. It is based on the analysis of the curvature of the objects contour. The method has…

Computer Vision and Pattern Recognition · Computer Science 2022-01-11 Miquel Miró-Nicolau , Biel Moyà-Alcover , Manuel Gonzàlez-Hidalgo , Antoni Jaume-i-Capó

Automatic segmentation of brain Magnetic Resonance Imaging (MRI) images is one of the vital steps for quantitative analysis of brain for further inspection. In this paper, NeuroNet has been adopted to segment the brain tissues (white matter…

Computer Vision and Pattern Recognition · Computer Science 2019-04-02 Fakrul Islam Tushar , Basel Alyafi , Md. Kamrul Hasan , Lavsen Dahal

Diffusion MRI (dMRI) tractography enables in vivo mapping of brain structural connections, but traditional connectome generation is time-consuming and requires gray matter parcellation, posing challenges for large-scale studies. We…

Image and Video Processing · Electrical Eng. & Systems 2025-06-12 Marcus J. Vroemen , Yuqian Chen , Yui Lo , Tengfei Xue , Weidong Cai , Fan Zhang , Josien P. W. Pluim , Lauren J. O'Donnell

Whole-brain neural connectivity data are now available from viral tracing experiments, which reveal the connections between a source injection site and elsewhere in the brain. These hold the promise of revealing spatial patterns of…

Neurons and Cognition · Quantitative Biology 2016-10-27 Kameron Decker Harris , Stefan Mihalas , Eric Shea-Brown