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Computed tomography (CT) has been a powerful diagnostic tool since its emergence in the 1970s. Using CT data, three-dimensional (3D) structures of human internal organs and tissues, such as blood vessels, can be reconstructed using…
We proposed a fully automatic workflow for glioblastoma (GBM) survival prediction using deep learning (DL) methods. 285 glioma (210 GBM, 75 low-grade glioma) patients were included. 163 of the GBM patients had overall survival (OS) data.…
Background and Purpose: Our purpose was to develop a deep learning angiography (DLA) method to generate 3D cerebral angiograms from a single contrast-enhanced acquisition. Material and Methods: Under an approved IRB protocol 105 3D-DSA…
Deep learning based computed tomography (CT) reconstruction has demonstrated outstanding performance on simulated 2D low-dose CT data. This applies in particular to domain adapted neural networks, which incorporate a handcrafted physics…
The advancement of artificial intelligence (AI) for organ segmentation and tumor detection is propelled by the growing availability of computed tomography (CT) datasets with detailed, per-voxel annotations. However, these AI models often…
In Magnetic Resonance Imaging (MRI), image acquisitions are often undersampled in the measurement domain to accelerate the scanning process, at the expense of image quality. However, image quality is a crucial factor that influences the…
Non-coplanar Intensity-Modulated Radiation Therapy (IMRT) goes a step further by orienting the gantry carrying the radiation beam and the patient couch in a non-coplanar manner to accurately target the cancer region and better avoid…
Evaluation metrics in machine learning are often hardly taken as loss functions, as they could be non-differentiable and non-decomposable, e.g., average precision and F1 score. This paper aims to address this problem by revisiting the…
This paper introduces a deep neural network based method, i.e., DeepOrganNet, to generate and visualize high-fidelity 3D / 4D organ geometric models from single-view medical image in real time. Traditional 3D / 4D medical image…
Purpose: We propose a general framework for quantifying predictive uncertainties of dose-related quantities and leveraging this information in a dose mimicking problem in the context of automated radiation therapy treatment planning.…
Computational fluid dynamics (CFD) simulations, a critical tool in various engineering applications, often require significant time and compute power to predict flow properties. The high computational cost associated with CFD simulations…
Historically, patient datasets have been used to develop and validate various reconstruction algorithms for PET/MRI and PET/CT. To enable such algorithm development, without the need for acquiring hundreds of patient exams, in this paper we…
Magnetic resonance imaging (MRI) is a non-invasive imaging modality and provides comprehensive anatomical and functional insights into the human body. However, its long acquisition times can lead to patient discomfort, motion artifacts, and…
Accurate 3D dose calculation for Pencil Beam Scanning Proton Therapy (PBSPT) is typically performed with Monte Carlo (MC) engines, but their runtimes limit adaptive workflows and repeated evaluations. Current deep-learning proton dose…
The construction of three-dimensional multi-modal tissue maps provides an opportunity to spur interdisciplinary innovations across temporal and spatial scales through information integration. While the preponderance of effort is allocated…
We demonstrate the application of mixture density networks (MDNs) in the context of automated radiation therapy treatment planning. It is shown that an MDN can produce good predictions of dose distributions as well as reflect uncertain…
Protoacoustic imaging showed great promise in providing real-time 3D dose verification of proton therapy. However, the limited acquisition angle in protoacoustic imaging induces severe artifacts, which significantly impairs its accuracy for…
4D Computed Tomography (4DCT) is widely used for many clinical applications such as radiotherapy treatment planning, PET and ventilation imaging. However, common 4DCT methods reconstruct multiple breath cycles into a single, arbitrary…
In this paper, we introduce a completion framework to reconstruct the geometric shapes of various anatomies, including organs, vessels and muscles. Our work targets a scenario where one or multiple anatomies are missing in the imaging data…
Purpose. - Radiotherapy is an important treatment for prostate cancer.During treatment sessions, bladder and rectal repletion is difficult to quantify and cannot be measured with a single and initial CT scan acquisition. Some methods, such…