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In longitudinal studies, time-varying covariates are often endogenous, meaning their values depend on both their own history and that of the outcome variable. This violates key assumptions of Generalized Linear Mixed Effects Models (GLMMs),…

Non-gaussian spatial data are very common in many disciplines. For instance, count data are common in disease mapping, and binary data are common in ecology. When fitting spatial regressions for such data, one needs to account for…

Methodology · Statistics 2010-12-01 John Hughes , Murali Haran

Spatial dependence, referring to the correlation between variable values observed at different geographic locations, is one of the most fundamental characteristics of spatial data. The presence of spatial dependence violates the classical…

Physics and Society · Physics 2025-06-23 Chuan Chen , Peng Luo

In the era of big data, the increasing availability of diverse data sources has driven interest in analytical approaches that integrate information across sources to enhance statistical accuracy, efficiency, and scientific insights. Many…

Methodology · Statistics 2026-03-30 Lu Wang , Yanyuan Ma , Jiwei Zhao

Health outcomes depend on complex environmental and sociodemographic factors whose effects change over location and time. Only recently has fine-grained spatial and temporal data become available to study these effects, namely the MEDSAT…

Machine Learning · Computer Science 2025-01-07 Ishaan Maitra , Raymond Lin , Eric Chen , Jon Donnelly , Sanja Šćepanović , Cynthia Rudin

Continuous space species distribution models (SDMs) have a long-standing history as a valuable tool in ecological statistical analysis. Geostatistical and preferential models are both common models in ecology. Geostatistical models are…

Applications · Statistics 2023-07-17 Mario Figueira , David Conesa , Antonio López-Quílez , Iosu Paradinas

We consider statistical inference in high-dimensional regression problems under affine constraints on the parameter space. The theoretical study of this is motivated by the study of genetic determinants of diseases, such as diabetes, using…

Maps have long been been used to visualise estimates of spatial variables, in particular disease burden and risk. Predictions made using a geostatistical model have uncertainty that typically varies spatially. However, this uncertainty is…

Applications · Statistics 2020-05-26 Aimee R Taylor , James A Watson , Caroline O Buckee

Driven by an increasing prevalence of trackers, ever more IoT sensors, and the declining cost of computing power, geospatial information has come to play a pivotal role in contemporary predictive models. While enhancing prognostic…

Machine Learning · Computer Science 2024-01-30 Agathe Fernandes Machado , François Hu , Philipp Ratz , Ewen Gallic , Arthur Charpentier

Geostatistical modeling for continuous point-referenced data has been extensively applied to neuroimaging because it produces efficient and valid statistical inference. However, diffusion tensor imaging (DTI), a neuroimaging characterizing…

Household survey data from the Demographic and Health Surveys (DHS) Program is published with GPS coordinates. However, almost all geostatistical analyses of such data ignore that the published GPS coordinates are randomly displaced…

Computation · Statistics 2022-12-05 Umut Altay , John Paige , Andrea Riebler , Geir-Arne Fuglstad

Spatial confounding between the spatial random effects and fixed effects covariates has been recently discovered and showed that it may bring misleading interpretation to the model results. Solutions to alleviate this problem are based on…

Methodology · Statistics 2016-05-17 Marcos O. Prates , Erica C. Rodrigues , Renato M. Assunção

This paper addresses the asymptotic performance of popular spatial regression estimators of the linear effect of an exposure on an outcome under ``spatial confounding" -- the presence of an unmeasured spatially-structured variable…

Methodology · Statistics 2024-09-19 Brian Gilbert , Elizabeth L. Ogburn , Abhirup Datta

Many in-hospital mortality risk prediction scores dichotomize predictive variables to simplify the score calculation. However, hard thresholding in these additive stepwise scores of the form "add x points if variable v is above/below…

Machine Learning · Statistics 2015-04-30 Natalia M. Arzeno , Karla A. Lawson , Sarah V. Duzinski , Haris Vikalo

Epidemiological investigations of regionally aggregated spatial data often involve detecting spatial health disparities among neighboring regions on a map of disease mortality or incidence rates. Analyzing such data introduces spatial…

Methodology · Statistics 2025-11-21 Kyle Lin Wu , Sudipto Banerjee

We present a novel approach for the analysis of multivariate case-control georeferenced data using Bayesian inference in the context of disease mapping, where the spatial distribution of different types of cancers is analyzed. Extending…

The issue of spatial confounding between the spatial random effect and the fixed effects in regression analyses has been identified as a concern in the statistical literature. Multiple authors have offered perspectives and potential…

Methodology · Statistics 2023-01-18 Kori Khan , Catherine A. Calder

Statistical learning theory provides the foundation to applied machine learning, and its various successful applications in computer vision, natural language processing and other scientific domains. The theory, however, does not take into…

Machine Learning · Statistics 2021-02-18 Júlio Hoffimann , Maciel Zortea , Breno de Carvalho , Bianca Zadrozny

This article introduces new methods for inference with count data registered on a set of aggregation units. Such data are omnipresent in epidemiology due to confidentiality issues: it is much more common to know the county in which an…

Methodology · Statistics 2017-04-20 Benjamin M. Taylor , Ricardo Andrade-Pacheco , Hugh J. W. Sturrock

In observational studies, researchers must select a method to control for confounding. Options include propensity score methods and regression. It remains unclear how dataset characteristics (size, overlap in propensity scores, exposure…

Methodology · Statistics 2022-10-21 J. Wilkinson , M. A. Mamas , E. Kontopantelis