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Current advances in neurosciences deal with the functional architecture of the central nervous system, paving the way for holistic theories that improve our understanding of brain activity. From topology, a strong concept comes into play in…
How the information microscopically processed by individual neurons is integrated and used in organizing the behavior of an animal is a central question in neuroscience. The coherence of neuronal dynamics over different scales has been…
We address the functional role of 'feature inhibition' in vision models; that is, what are the mechanisms by which a neural network ensures images do not express a given feature? We observe that standard interpretability tools in the…
Synchronized oscillations in networks of inhibitory and excitatory coupled bursting neurons are common in a variety of neural systems from central pattern generators to human brain circuits. One example of the latter is the subcortical…
Anatomy of the human brain constrains the formation of large-scale functional networks. Here, given measured brain activity in gray matter, we interpolate these functional signals into the white matter on a structurally-informed…
Unraveling the interplay of excitation and inhibition within rhythm-generating networks remains a fundamental issue in neuroscience. We use a biophysical model to investigate the different roles of local and long-range inhibition in the…
At the macroscale, the brain operates as a network of interconnected neuronal populations, which display rhythmic dynamics that support interareal communication. Understanding how stimulation of a particular brain area impacts such…
Many car accidents are caused by human distractions, including cognitive distractions. In-vehicle human-machine interfaces (HMIs) have evolved throughout the years, providing more and more functions. Interaction with the HMIs can, however,…
A new theory of mammalian hearing is presented, which accounts for the auditory image in the midbrain (inferior colliculus) of objects in the acoustical environment of the listener. It is shown that the ear is a temporal imaging system that…
We address the well-known limitation of the Huxley and Simmons 1971 (HS) model. It is a statement that at physiological value of stiffness in the actomyosin complex, the distribution of the myosin motors becomes microscopically uniform (all…
The neural networks of the brain are capable of learning statistical input regularities on the basis of synaptic learning, functional integration into increasingly larger, interconnected neural assemblies, and self organization. This self…
Mammalian functional architecture flexibly adapts, transitioning from integration where information is distributed across the cortex, to segregation where information is focal in densely connected communities of brain regions. This…
Adequate brain perfusion is required for proper brain function and life. Maintaining optimal brain perfusion to avoid secondary brain injury is one of the main concerns of neurocritical care. Cerebral autoregulation is responsible for…
Uncontrolled, excessive production of pro-inflammatory mediators from immune cells and traumatized tissues can cause systemic inflammatory issues like sepsis, one of the ten leading causes of death in the United States and one of the three…
Multimodal large reasoning models (MLRMs) often suffer from hallucinations that stem not only from insufficient visual grounding but also from imbalanced allocation between perception and reasoning processes. Building upon recent…
In the mammalian brain, newly acquired memories depend on the hippocampus for maintenance and recall, but over time the neocortex takes over these functions, rendering memories hippocampus-independent. The process responsible for this…
A new brain model is introduced, based on the Impulse Pattern Formulation (IPF) already established for modeling and understanding musical instrument and rhythm perception and production. It assumes the brain works with impulses, neural…
Dehydration and brain interstitial fluid alterations associate to cognitive dysfunction. We now explore whether changes in matrix hydration are a possible common signal for modulation of water-transfer rates and neuron function.
Cooperative action of molecular motors is essential for many cellular processes. One possible regulator of motor coordination is the elasticity-mediated crosstalk (EMC) coupling between myosin II motors whose origin is the tensile stress…
Sleep is essential for the maintenance of the brain and the body, yet many features of sleep are poorly understood and mathematical models are an important tool for probing proposed biological mechanisms. The most well-known mathematical…