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Evaluating hypothetical statements about how the world would be had a different course of action been taken is arguably one key capability expected from modern AI systems. Counterfactual reasoning underpins discussions in fairness, the…

Machine Learning · Computer Science 2022-10-04 Kevin Xia , Yushu Pan , Elias Bareinboim

While much attention has been given to the problem of estimating the effect of discrete interventions from observational data, relatively little work has been done in the setting of continuous-valued interventions, such as treatments…

Machine Learning · Computer Science 2020-11-24 Ioana Bica , James Jordon , Mihaela van der Schaar

Effective therapy decisions require models that predict the individual response to treatment. This is challenging since the progression of disease and response to treatment vary substantially across patients. Here, we propose to learn a…

Computer Vision and Pattern Recognition · Computer Science 2025-09-19 Ivana Janíčková , Yen Y. Tan , Thomas H. Helbich , Konstantin Miloserdov , Zsuzsanna Bago-Horvath , Ulrike Heber , Georg Langs

Accuracy and interpretability are two dominant features of successful predictive models. Typically, a choice must be made in favor of complex black box models such as recurrent neural networks (RNN) for accuracy versus less accurate but…

Machine Learning · Computer Science 2017-02-28 Edward Choi , Mohammad Taha Bahadori , Joshua A. Kulas , Andy Schuetz , Walter F. Stewart , Jimeng Sun

Dynamic prediction of causal effects under different treatment regimes conditional on an individual's characteristics and longitudinal history is an essential problem in precision medicine. This is challenging in practice because outcomes…

Methodology · Statistics 2023-03-07 Yizhen Xu , Jisoo Kim , Laura K. Hummers , Ami A. Shah , Scott Zeger

Despite intense efforts in basic and clinical research, an individualized ventilation strategy for critically ill patients remains a major challenge. Recently, dynamic treatment regime (DTR) with reinforcement learning (RL) on electronic…

Machine Learning · Computer Science 2022-06-01 Changchang Yin , Ruoqi Liu , Jeffrey Caterino , Ping Zhang

Recurrent neural networks have proven effective in modeling sequential user feedbacks for recommender systems. However, they usually focus solely on item relevance and fail to effectively explore diverse items for users, therefore harming…

Machine Learning · Computer Science 2022-02-17 Hao Wang , Yifei Ma , Hao Ding , Yuyang Wang

Estimating treatment effects from observational data is challenging due to two main reasons: (a) hidden confounding, and (b) covariate mismatch (control and treatment groups not having identical distributions). Long lines of works exist…

Machine Learning · Computer Science 2025-04-30 Praharsh Nanavati , Ranjitha Prasad , Karthikeyan Shanmugam

We consider after-study statistical inference for sequentially designed experiments wherein multiple units are assigned treatments for multiple time points using treatment policies that adapt over time. Our goal is to provide inference…

Machine Learning · Statistics 2025-06-10 Raaz Dwivedi , Katherine Tian , Sabina Tomkins , Predrag Klasnja , Susan Murphy , Devavrat Shah

This paper tackles the problem of time-to-event counterfactual survival prediction, aiming to optimize individualized survival outcomes in the presence of heterogeneity and censored data. We propose CURE, a framework that advances…

Learning representations for counterfactual inference from observational data is of high practical relevance for many domains, such as healthcare, public policy and economics. Counterfactual inference enables one to answer "What if...?"…

Machine Learning · Computer Science 2019-05-28 Patrick Schwab , Lorenz Linhardt , Walter Karlen

Temporal link prediction is crucial for rapidly growing social networks. Existing methods often overlook the underlying causal mechanisms that drive link formation, making it difficult for algorithms to adapt to complex structures that…

Machine Learning · Computer Science 2026-05-12 Hantong Feng , Duxin Chen , Wenwu Yu

Choosing optimal (or at least better) policies is an important problem in domains from medicine to education to finance and many others. One approach to this problem is through controlled experiments/trials - but controlled experiments are…

Artificial Intelligence · Computer Science 2018-02-26 Onur Atan , William R. Zame , M van der Schaar

In this study, we develop consistent estimators for key parameters that govern the dynamics of tumor cell populations when subjected to pharmacological treatments. While these treatments often lead to an initial reduction in the abundance…

Applications · Statistics 2024-03-21 Kevin Leder , Ruping Sun , Zicheng Wang , Xuanming Zhang

Counterfactual reasoning from logged data has become increasingly important for many applications such as web advertising or healthcare. In this paper, we address the problem of learning stochastic policies with continuous actions from the…

Machine Learning · Statistics 2025-02-24 Houssam Zenati , Alberto Bietti , Matthieu Martin , Eustache Diemert , Pierre Gaillard , Julien Mairal

Personalized head and neck cancer therapeutics have greatly improved survival rates for patients, but are often leading to understudied long-lasting symptoms which affect quality of life. Sequential rule mining (SRM) is a promising…

Human-Computer Interaction · Computer Science 2023-09-28 Carla Floricel , Andrew Wentzel , Abdallah Mohamed , C. David Fuller , Guadalupe Canahuate , G. Elisabeta Marai

Objective: To develop an effective and scalable individual-level patient cost prediction method by automatically learning hidden temporal patterns from multivariate time series data in patient insurance claims using a convolutional neural…

Machine Learning · Computer Science 2020-09-16 Mohammad Amin Morid , Olivia R. Liu Sheng , Kensaku Kawamoto , Samir Abdelrahman

Sound events often occur in unstructured environments where they exhibit wide variations in their frequency content and temporal structure. Convolutional neural networks (CNN) are able to extract higher level features that are invariant to…

Machine Learning · Computer Science 2017-05-31 Emre Çakır , Giambattista Parascandolo , Toni Heittola , Heikki Huttunen , Tuomas Virtanen

Chemical reaction networks (CRNs) provide a convenient language for modelling a broad variety of biological systems. These models are commonly studied with respect to the time series they generate in deterministic or stochastic simulations.…

Molecular Networks · Quantitative Biology 2019-07-11 Ozan Kahramanoğulları

Improving the performance of click-through rate (CTR) prediction remains one of the core tasks in online advertising systems. With the rise of deep learning, CTR prediction models with deep networks remarkably enhance model capacities. In…

Machine Learning · Computer Science 2019-11-05 Yikai Wang , Liang Zhang , Quanyu Dai , Fuchun Sun , Bo Zhang , Yang He , Weipeng Yan , Yongjun Bao
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