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This work presents an unsupervised deep discriminant analysis for clustering. The method is based on deep neural networks and aims to minimize the intra-cluster discrepancy and maximize the inter-cluster discrepancy in an unsupervised…

Machine Learning · Computer Science 2022-06-13 Jinyu Cai , Wenzhong Guo , Jicong Fan

Quantifiable image patterns associated with disease progression and treatment response are critical tools for guiding individual treatment, and for developing novel therapies. Here, we show that unsupervised machine learning can identify a…

Image and Video Processing · Electrical Eng. & Systems 2025-07-17 Matthias Perkonigg , Nina Bastati , Ahmed Ba-Ssalamah , Peter Mesenbrink , Alexander Goehler , Miljen Martic , Xiaofei Zhou , Michael Trauner , Georg Langs

The lack of large labeled medical imaging datasets, along with significant inter-individual variability compared to clinically established disease classes, poses significant challenges in exploiting medical imaging information in a…

Computer Vision and Pattern Recognition · Computer Science 2022-09-27 Matteo Ferrante , Tommaso Boccato , Simeon Spasov , Andrea Duggento , Nicola Toschi

We propose a Deep Variational Clustering (DVC) framework for unsupervised representation learning and clustering of large-scale medical images. DVC simultaneously learns the multivariate Gaussian posterior through the probabilistic…

Computer Vision and Pattern Recognition · Computer Science 2021-09-23 Farzin Soleymani , Mohammad Eslami , Tobias Elze , Bernd Bischl , Mina Rezaei

Medical image analysis using supervised deep learning methods remains problematic because of the reliance of deep learning methods on large amounts of labelled training data. Although medical imaging data repositories continue to expand…

Computer Vision and Pattern Recognition · Computer Science 2019-06-11 Euijoon Ahn , Ashnil Kumar , Dagan Feng , Michael Fulham , Jinman Kim

This project aims to break down large pathology images into small tiles and then cluster those tiles into distinct groups without the knowledge of true labels, our analysis shows how difficult certain aspects of clustering tumorous and…

Image and Video Processing · Electrical Eng. & Systems 2020-12-29 Mostafa Ibrahim , Kevin Bryson

In recent years, the research landscape of machine learning in medical imaging has changed drastically from supervised to semi-, weakly- or unsupervised methods. This is mainly due to the fact that ground-truth labels are time-consuming and…

Image and Video Processing · Electrical Eng. & Systems 2021-10-04 Turkay Kart , Wenjia Bai , Ben Glocker , Daniel Rueckert

This paper presents a novel unsupervised segmentation method for 3D medical images. Convolutional neural networks (CNNs) have brought significant advances in image segmentation. However, most of the recent methods rely on supervised…

Computer Vision and Pattern Recognition · Computer Science 2018-04-13 Takayasu Moriya , Holger R. Roth , Shota Nakamura , Hirohisa Oda , Kai Nagara , Masahiro Oda , Kensaku Mori

The identification and quantification of markers in medical images is critical for diagnosis, prognosis and management of patients in clinical practice. Supervised- or weakly supervised training enables the detection of findings that are…

In this work, we propose to use a local clustering approach based on the sparse solution technique to study the medical image, especially the lung cancer image classification task. We view images as the vertices in a weighted graph and the…

Computer Vision and Pattern Recognition · Computer Science 2025-05-22 Jackson Hamel , Ming-Jun Lai , Zhaiming Shen , Ye Tian

Local discriminative representation is needed in many medical image analysis tasks such as identifying sub-types of lesion or segmenting detailed components of anatomical structures. However, the commonly applied supervised representation…

Computer Vision and Pattern Recognition · Computer Science 2021-03-25 Huai Chen , Jieyu Li , Renzhen Wang , Yijie Huang , Fanrui Meng , Deyu Meng , Qing Peng , Lisheng Wang

The clustering of unlabeled raw images is a daunting task, which has recently been approached with some success by deep learning methods. Here we propose an unsupervised clustering framework, which learns a deep neural network in an…

Computer Vision and Pattern Recognition · Computer Science 2020-12-16 Guy Shiran , Daphna Weinshall

Ultrasound imaging is challenging to interpret due to non-uniform intensities, low contrast, and inherent artifacts, necessitating extensive training for non-specialists. Advanced representation with clear tissue structure separation could…

Computer Vision and Pattern Recognition · Computer Science 2024-08-06 Oleksandra Tmenova , Yordanka Velikova , Mahdi Saleh , Nassir Navab

We propose a deep clustering architecture alongside image segmentation for medical image analysis. The main idea is based on unsupervised learning to cluster images on severity of the disease in the subject's sample, and this image is then…

Image and Video Processing · Electrical Eng. & Systems 2020-05-28 Sharmin Pathan , Anant Tripathi

Unsupervised machine learning, and in particular data clustering, is a powerful approach for the analysis of datasets and identification of characteristic features occurring throughout a dataset. It is gaining popularity across scientific…

Mesoscale and Nanoscale Physics · Physics 2021-03-23 Maria El Abbassi , Jan Overbeck , Oliver Braun , Michel Calame , Herre S. J. van der Zant , Mickael L. Perrin

Clustering is a class of unsupervised learning methods that has been extensively applied and studied in computer vision. Little work has been done to adapt it to the end-to-end training of visual features on large scale datasets. In this…

Computer Vision and Pattern Recognition · Computer Science 2019-03-19 Mathilde Caron , Piotr Bojanowski , Armand Joulin , Matthijs Douze

Deep learning has become the mainstream methodological choice for analyzing and interpreting whole-slide digital pathology images (WSIs). It is commonly assumed that tumor regions carry most predictive information. In this paper, we…

Quantitative Methods · Quantitative Biology 2022-04-26 Zihan Chen , Xingyu Li , Miaomiao Yang , Hong Zhang , Xu Steven Xu

We propose a deep learning clustering method that exploits dense features from a segmentation network for emphysema subtyping from computed tomography (CT) scans. Using dense features enables high-resolution visualization of image regions…

Image and Video Processing · Electrical Eng. & Systems 2021-06-03 Weiyi Xie , Colin Jacobs , Bram van Ginneken

In the face of complex natural images, existing deep clustering algorithms fall significantly short in terms of clustering accuracy when compared to supervised classification methods, making them less practical. This paper introduces an…

Machine Learning · Computer Science 2024-08-13 Qiuyu Zhu , Liheng Hu , Sijin Wang

Unlike common cancers, such as those of the prostate and breast, tumor grading in rare cancers is difficult and largely undefined because of small sample sizes, the sheer volume of time needed to undertake on such a task, and the inherent…

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