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This dissertation explores applications of discrete geometry in mathematical neuroscience. We begin with convex neural codes, which model the activity of hippocampal place cells and other neurons with convex receptive fields. In Chapter 4,…

Neurons and Cognition · Quantitative Biology 2022-09-19 Caitlin Lienkaemper

A combinatorial neural code is a subset of the power set $2^{[n]}$ on $[n]=\{1,\dots, n\}$, in which each $1\leq i\leq n$ represents a neuron and each element (codeword) represents the co-firing event of some neurons. Consider a space…

Combinatorics · Mathematics 2025-12-05 R. Amzi Jeffs , Trong-Thuc Trang

Convex neural codes are combinatorial structures describing the intersection pattern of a collection of convex sets. Inductively pierced codes are a particularly nice subclass of neural codes introduced in the information visualization…

Combinatorics · Mathematics 2019-07-01 Caitlin Lienkaemper

Convex neural codes are subsets of the Boolean lattice that record the intersection patterns of convex sets in Euclidean space. Much work in recent years has focused on finding combinatorial criteria on codes that can be used to classify…

Combinatorics · Mathematics 2020-12-18 R. Amzi Jeffs , Caitlin Lienkaemper , Nora Youngs

Neural codes allow the brain to represent, process, and store information about the world. Combinatorial codes, comprised of binary patterns of neural activity, encode information via the collective behavior of populations of neurons. A…

Neurons and Cognition · Quantitative Biology 2016-12-22 Carina Curto , Elizabeth Gross , Jack Jeffries , Katherine Morrison , Mohamed Omar , Zvi Rosen , Anne Shiu , Nora Youngs

Neural codes serve as a language for neurons in the brain. Convex codes, which arise from the pattern of intersections of convex sets in Euclidean space, are of particular relevance to neuroscience. Not every code is convex, however, and…

Combinatorics · Mathematics 2017-05-31 Joshua Cruz , Chad Giusti , Vladimir Itskov , Bill Kronholm

We investigate combinatorial, topological and algebraic properties of certain classes of neural codes. We look into a conjecture that states if the minimal \textit{open convex} embedding dimension of a neural code is two then its minimal…

Geometric Topology · Mathematics 2023-09-21 Neha Gupta , Suhith K N

Neural codes, represented as collections of binary strings called codewords, are used to encode neural activity. A code is called convex if its codewords are represented as an arrangement of convex open sets in Euclidean space. Previous…

Combinatorics · Mathematics 2022-08-10 Katherine Johnston , Anne Shiu , Clare Spinner

A convex code is a binary code generated by the pattern of intersections of a collection of open convex sets in some Euclidean space. Convex codes are relevant to neuroscience as they arise from the activity of neurons that have convex…

Neurons and Cognition · Quantitative Biology 2018-07-10 Carina Curto , Elizabeth Gross , Jack Jeffries , Katherine Morrison , Zvi Rosen , Anne Shiu , Nora Youngs

A combinatorial code $\mathcal{C}$ is a collection of subsets of $[n]$, or equivalently a set of points in $\{0,1\}^n$. A morphism of codes is a map from one combinatorial code to another such that the coordinates of points in the image can…

Combinatorics · Mathematics 2026-03-12 Juliann Geraci , Alexander B. Kunin , Alexandra Seceleanu

Combinatorial neural codes are $0/1$ vectors that are used to model the co-firing patterns of a set of place cells in the brain. One wide-open problem in this area is to determine when a given code can be algorithmically drawn in the plane…

Combinatorics · Mathematics 2018-08-29 Robert Davis

We introduce new geometric and combinatorial criteria that preclude a neural code from being convex, and use them to tackle the classification problem for codes on six neurons. Along the way, we give the first example of a code that is…

Combinatorics · Mathematics 2023-02-16 Laura Matusevich , Alexander Ruys de Perez , Anne Shiu

Neural codes are binary codes that are used for information processing and representation in the brain. In previous work, we have shown how an algebraic structure, called the {\it neural ring}, can be used to efficiently encode geometric…

Neurons and Cognition · Quantitative Biology 2019-02-14 Carina Curto , Nora Youngs

Neural codes are lists of subsets of neurons that fire together. Of particular interest are neurons called place cells, which fire when an animal is in specific, usually convex regions in space. A fundamental question, therefore, is to…

Combinatorics · Mathematics 2021-04-05 Brianna Gambacini , R. Amzi Jeffs , Sam Macdonald , Anne Shiu

Neural codes, represented as collections of binary strings, encode neural activity and show relationships among stimuli. Certain neurons, called place cells, have been shown experimentally to fire in convex regions in space. A natural…

Neurons and Cognition · Quantitative Biology 2019-09-20 Sarah Ayman Goldrup , Kaitlyn Phillipson

Neural codes are collections of binary strings motivated by patterns of neural activity. In this paper, we study algorithmic and enumerative aspects of convex neural codes in dimension 1 (i.e. on a line or a circle). We use the theory of…

Combinatorics · Mathematics 2017-02-23 Zvi Rosen , Yan X. Zhang

Why do neurons encode information the way they do? Normative answers to this question model neural activity as the solution to an optimisation problem; for example, the celebrated efficient coding hypothesis frames neural activity as the…

Neurons and Cognition · Quantitative Biology 2026-03-06 William Dorrell , Peter E. Latham , James Whittington

Determining how the brain stores information is one of the most pressing problems in neuroscience. In many instances, the collection of stimuli for a given neuron can be modeled by a convex set in $\mathbb{R}^d$. Combinatorial objects known…

Combinatorics · Mathematics 2019-05-29 R. Amzi Jeffs , Mohamed Omar , Natchanon Suaysom , Aleina Wachtel , Nora Youngs

Given an intersection pattern of arbitrary sets in Euclidean space, is there an arrangement of convex open sets in Euclidean space that exhibits the same intersections? This question is combinatorial and topological in nature, but is…

Combinatorics · Mathematics 2019-02-22 Aaron Chen , Florian Frick , Anne Shiu

An affine oriented matroid is a combinatorial abstraction of an affine hyperplane arrangement. From it, Novik, Postnikov and Sturmfels constructed a squarefree monomial ideal in a polynomial ring, called an oriented matroid ideal, and got…

Commutative Algebra · Mathematics 2017-11-27 Ryota Okazaki , Kohji Yanagawa
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