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This study proposes an effective positive control design strategy for cancer treatment by resorting to the combination of immunotherapy and chemotherapy. The treatment objective is to transfer the initial number of tumor cells and…
The paper should be viewed as complement of an earlier result in [8]. In the paper just mentioned it is shown that 1d case of a quasilinear parabolic-elliptic Keller-Segel system is very special. Namely, unlike in higher dimensions, there…
In this paper, we prove global-in-time existence of strong solutions to a class of fractional parabolic reaction-diffusion systems posed in a bounded domain of $\mathbb{R}^N$. The nonlinear reactive terms are assumed to satisfy natural…
A re-entrant manufacturing system producing a large number of items and involving many steps can be approximately modeled by a hyperbolic partial differential equation (PDE) according to mass conservation law with respect to a continuous…
This paper investigates an optimal control problem associated with a two-dimensional multi-species Cahn-Hilliard-Keller-Segel tumor growth model, which incorporates complex biological processes such as species diffusion, chemotaxis,…
The traditional quantum control theory focuses on linear quantum system. Here we show the effect of nonlinearity on quantum control of a two-level system, we find that the nonlinearity can change the controllability of quantum system.…
In a separable Hilbert space $X$, we study the controlled evolution equation \begin{equation*} u'(t)+Au(t)+p(t)Bu(t)=0, \end{equation*} where $A\geq-\sigma I$ ($\sigma\geq0$) is a self-adjoint linear operator, $B$ is a bounded linear…
We construct solutions to the two dimensional parabolic-elliptic Keller-Segel model for chemotaxis that blow up in finite time $T$. The solution is decomposed as the sum of a stationary state concentrated at scale $\lambda$ and of a…
We consider a biphasic continuum model for avascular tumour growth in two spatial dimensions, in which a cell phase and a fluid phase follow conservation of mass and momentum. A limiting nutrient that follows a diffusion process controls…
In this paper, a reaction-diffusion system modeling injection of a chemotherapeutic drug on the surface of a living tissue during a treatment for cancer patients is studied. The system describes the interaction of the chemotherapeutic drug…
This work concentrates on a class of optimal control problems for semilinear parabolic equations subject to control constraint of the form $\|u(t)\|_{L^1(\Omega)} \le \gamma$ for $t \in (0,T)$. This limits the total control that can be…
This article deals with an initial-boundary value problem for the coupled chemotaxis-haptotaxis system with nonlinear diffusion \begin{align*} u_t=&\nabla\cdot(D(u)\nabla u)-\chi\nabla\cdot(u\nabla v)-\xi\nabla\cdot(u\nabla w)+\mu…
We consider the quasilinear parabolic-parabolic Keller-Segel system $$ u_t=\nabla \cdot (D(u)\nabla u) - \nabla \cdot (S(u)\nabla v), \qquad x\in\Omega, \ t>0, v_t=\Delta v -v + u, x\in\Omega, \ t>0, $$ under homogeneous Neumann boundary…
This paper is concerned with optimal control problems for parabolic partial differential equations with pointwise in time switching constraints on the control. A standard approach to treat constraints in nonlinear optimization is…
The two contributions of this paper are as follows. The first is the solution of an infinite dimensional, boundary controlled Linear Quadratic Regulator by the simple and constructive method of completing the square. The second contribution…
We consider a bilinear optimal control for an evolution equation involving the fractional Laplace operator of order $0<s<1$. We first give some existence and uniqueness results for the considered evolution equation. Next, we establish some…
We consider a nonlinear reaction diffusion system of parabolic type known as the monodomain equations, which model the interaction of the electric current in a cell. Together with the FitzHugh-Nagumo model for the nonlinearity they…
This paper is concerned with the state-constrained optimal control of the three-dimensional thermistor problem, a fully quasilinear coupled system of a parabolic and elliptic PDE with mixed boundary conditions. This system models the…
We study a system of two coupled nonlinear parabolic equations. It constitutes a variant of the Keller-Segel model for chemotaxis, i.e. it models the behaviour of a population of bacteria that interact by means of a signalling substance. We…
We consider a linear Schr\"odinger equation, on a bounded interval, with bilinear control, that represents a quantum particle in an electric field (the control). We prove the controllability of this system, in any positive time, locally…