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Deployment of machine learning models in real high-risk settings (e.g. healthcare) often depends not only on the model's accuracy but also on its fairness, robustness, and interpretability. Generalized Additive Models (GAMs) are a class of…

Machine Learning · Computer Science 2022-03-17 Chun-Hao Chang , Rich Caruana , Anna Goldenberg

Nonlinear relationships between covariates and a response variable of interest are frequently encountered in animal science research. Within statistical models, these nonlinear effects have, traditionally, been handled using a range of…

Applications · Statistics 2025-10-28 Gavin L. Simpson

Meta-analysis, because of both logistical convenience and statistical efficiency, is widely popular for synthesizing information on common parameters of interest across multiple studies. We propose developing a generalized meta-analysis…

Methodology · Statistics 2018-11-27 Prosenjit Kundu , Runlong Tang , Nilanjan Chatterjee

Neural networks have become a popular tool in predictive modelling, more commonly associated with machine learning and artificial intelligence than with statistics. Generalised Additive Models (GAMs) are flexible non-linear statistical…

Machine Learning · Statistics 2026-01-06 Jessica Doohan , Lucas Kook , Kevin Burke

Genetic association studies are becoming an important component of medical research. To cite one instance, pharmacogenomics which is gaining prominence as a useful tool for personalized medicine is heavily reliant on results from genetic…

Applications · Statistics 2018-03-13 Majnu John , Todd Lencz , Anil K Malhotra , Christoph U Correll , Jian-Ping Zhang

Neuroimaging meta-analysis is an area of growing interest in statistics. The special characteristics of neuroimaging data render classical meta-analysis methods inapplicable and therefore new methods have been developed. We review existing…

Applications · Statistics 2017-11-30 Pantelis Samartsidis , Silvia Montagna , Thomas E. Nichols , Timothy D. Johnson

Generalized additive models (GAMs) provide a way to blend parametric and non-parametric (function approximation) techniques together, making them flexible tools suitable for many modeling problems. For instance, GAMs can be used to…

Methodology · Statistics 2023-03-07 Antti Solonen , Stratos Staboulis

Machine learning provides a valuable tool for analyzing high-dimensional functional neuroimaging data, and is proving effective in predicting various neurological conditions, psychiatric disorders, and cognitive patterns. In functional…

Machine Learning · Computer Science 2024-11-25 Anwar Said , Roza G. Bayrak , Tyler Derr , Mudassir Shabbir , Daniel Moyer , Catie Chang , Xenofon Koutsoukos

Standard random-effects meta-analysis relies heavily on the assumption that the underlying true effects are normally distributed. In the social sciences, where evidence synthesis increasingly involves large, highly heterogeneous datasets,…

Methodology · Statistics 2026-05-01 Daihe Sui , Elizabeth Tipton

Reaching a global view of brain organization requires assembling evidence on widely different mental processes and mechanisms. The variety of human neuroscience concepts and terminology poses a fundamental challenge to relating brain…

Quantitative Methods · Quantitative Biology 2020-02-24 Jérôme Dockès , Russell Poldrack , Romain Primet , Hande Gözükan , Tal Yarkoni , Fabian Suchanek , Bertrand Thirion , Gaël Varoquaux

This is a hands-on introduction to Generalised Additive Mixed Models (GAMMs) in the context of linguistics with a particular focus on dynamic speech analysis (e.g. formant contours, pitch tracks, diachronic change, etc.). The main goal is…

Applications · Statistics 2017-03-17 Márton Sóskuthy

The rapid advancement of medical technology has led to an exponential increase in multi-modal medical data, including imaging, genomics, and electronic health records (EHRs). Graph neural networks (GNNs) have been widely used to represent…

Quantitative Methods · Quantitative Biology 2024-10-03 Favour Nerrise , Alice Louise Heiman , Ehsan Adeli

Multi-modality imaging improves disease diagnosis and reveals distinct deviations in tissues with anatomical properties. The existence of completely aligned and paired multi-modality neuroimaging data has proved its effectiveness in brain…

Image and Video Processing · Electrical Eng. & Systems 2023-09-26 Guoyang Xie , Yawen Huang , Jinbao Wang , Jiayi Lyu , Feng Zheng , Yefeng Zheng , Yaochu Jin

Meta-analysis aims to combine effect measures from several studies. For continuous outcomes, the most popular effect measures use simple or standardized differences in sample means. However, a number of applications focus on the absolute…

Methodology · Statistics 2023-10-03 Elena Kulinskaya , David C. Hoaglin

Additive smooth models, such as Generalized additive models (GAMs) of location, scale, and shape (GAMLSS), are a popular choice for modeling experimental data. However, software available to fit such models is usually not tailored…

Methodology · Statistics 2025-06-17 Joshua Krause , Jelmer P. Borst , Jacolien van Rij

Due to the widespread use of complex machine learning models in real-world applications, it is becoming critical to explain model predictions. However, these models are typically black-box deep neural networks, explained post-hoc via…

Machine Learning · Computer Science 2022-10-20 Filip Radenovic , Abhimanyu Dubey , Dhruv Mahajan

We present generalized additive latent and mixed models (GALAMMs) for analysis of clustered data with responses and latent variables depending smoothly on observed variables. A scalable maximum likelihood estimation algorithm is proposed,…

Methodology · Statistics 2023-03-29 Øystein Sørensen , Anders M. Fjell , Kristine B. Walhovd

Meta-analysis methods are used to combine evidence from multiple studies. Meta-regression as well as model-based meta-analysis are extensions of standard pairwise meta-analysis in which information about study-level covariates and…

Methodology · Statistics 2022-02-02 Burak Kürsad Günhan , Christian Röver , Tim Friede

When re-structuring patient cohorts into so-called population graphs, initially independent data points can be incorporated into one interconnected graph structure. This population graph can then be used for medical downstream tasks using…

Social and Information Networks · Computer Science 2023-09-20 Tamara T. Mueller , Sophie Starck , Leonhard F. Feiner , Kyriaki-Margarita Bintsi , Daniel Rueckert , Georgios Kaissis

Sparse generalized additive models (GAMs) are an extension of sparse generalized linear models which allow a model's prediction to vary non-linearly with an input variable. This enables the data analyst build more accurate models,…

Methodology · Statistics 2020-01-15 J. Kenneth Tay , Robert Tibshirani
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