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The out-of-equilibrium character of active systems is often twofold, arising from both the activity itself and from non-reciprocal couplings between constituents. A well-established measure to quantify the system's distance from equilibrium…

Statistical Mechanics · Physics 2026-02-13 Kim L. Kreienkamp , Sabine H. L. Klapp

Equilibrium Propagation (EP) is a physics-inspired learning algorithm that uses stationary states of a dynamical system both for inference and learning. In its original formulation it is limited to conservative systems, $\textit{i.e.}$ to…

Machine Learning · Computer Science 2026-02-04 Antonino Emanuele Scurria , Dimitri Vanden Abeele , Bortolo Matteo Mognetti , Serge Massar

Reaction diffusion systems are often used to study pattern formation in biological systems. However, most methods for understanding their behavior are challenging and can rarely be applied to complex systems common in biological…

Analysis of PDEs · Mathematics 2013-05-24 William R. Holmes

This work reviews deterministic and diffusion approximations of the stochastic chemical reaction networks and explains their applications. We discuss the added value the diffusion approximation provides for systems with different phenomena,…

Probability · Mathematics 2018-01-15 Pavel Mozgunov , Marco Beccuti , Andras Horvath , Thomas Jaki , Roberta Sirovich , Enrico Bibbona

We explore the possibility of designing matching mechanisms that can accommodate non-standard choice behavior. We pin down the necessary and sufficient conditions on participants' choice behavior for the existence of stable and incentive…

Theoretical Economics · Economics 2024-08-12 Gian Caspari , Manshu Khanna

A perfectly rational decision-maker chooses the best action with the highest utility gain from a set of possible actions. The optimality principles that describe such decision processes do not take into account the computational costs of…

Artificial Intelligence · Computer Science 2013-12-25 Jordi Grau-Moya , Daniel A. Braun

Interference between treated and untreated units is a source of bias in marketplace experiments. In this paper, we specifically consider pricing interventions, in which a platform seeks to adjust base pricing levels at the marketplace level…

Optimization and Control · Mathematics 2025-02-27 Arthur Delarue , Kleanthis Karakolios

How the brain performs credit assignment is a fundamental unsolved problem in neuroscience. Many `biologically plausible' algorithms have been proposed, which compute gradients that approximate those computed by backpropagation (BP), and…

Machine Learning · Computer Science 2022-08-05 Beren Millidge , Yuhang Song , Tommaso Salvatori , Thomas Lukasiewicz , Rafal Bogacz

The analysis of non-equilibrium steady states of biochemical reaction networks relies on finding the configurations of fluxes and chemical potentials satisfying stoichiometric (mass balance) and thermodynamic (energy balance) constraints.…

Molecular Networks · Quantitative Biology 2011-07-13 Daniele De Martino , Matteo Figliuzzi , Andrea De Martino , Enzo Marinari

The metabolic network of a living cell involves several hundreds or thousands of interconnected biochemical reactions. Previous research has shown that under realistic conditions only a fraction of these reactions is concurrently active in…

Molecular Networks · Quantitative Biology 2012-06-06 Joo Sang Lee , Takashi Nishikawa , Adilson E. Motter

How biological networks achieve robust control despite relying on imperfect, local information remains an important open question. Here, we identify thermodynamic constraints that can curtail non-equilibrium steady-state responses so…

Statistical Mechanics · Physics 2026-05-27 Carlos Floyd , Aaron R. Dinner , Suriyanarayanan Vaikuntanathan

We introduce thermodynamic networks, a general framework for autonomous, physics-based computation using non-equilibrium steady states. These networks are modeled as a collection of finite-size reservoirs that exchange conserved…

The Hopfield network has been applied to solve optimization problems over decades. However, it still has many limitations in accomplishing this task. Most of them are inherited from the optimization algorithms it implements. The computation…

Neural and Evolutionary Computing · Computer Science 2007-05-23 Xiaofei Huang

Biological systems sense and extract information from fluctuating signals while operating under energetic constraints and limited resolution. We introduce a general chemical model in which a sensor, coupled to a signaling pathway activated…

Statistical Mechanics · Physics 2025-12-09 Giorgio Nicoletti , Ivan Di Terlizzi , Daniel Maria Busiello

Chemical reaction networks can undergo nonequilibrium phase transitions upon variation of external control parameters like the chemical potential of a species. We investigate the flux in the associated chemostats that is proportional to the…

Statistical Mechanics · Physics 2024-05-07 Benedikt Remlein , Udo Seifert

Predictive coding (PC) is an energy-based learning algorithm that performs iterative inference over network activities before updating weights. Recent work suggests that PC can converge in fewer learning steps than backpropagation thanks to…

Machine Learning · Computer Science 2024-11-12 Francesco Innocenti , El Mehdi Achour , Ryan Singh , Christopher L. Buckley

Equilibrium Propagation (EP) is a supervised learning algorithm that trains network parameters using local neuronal activity. This is in stark contrast to backpropagation, where updating the parameters of the network requires significant…

Machine Learning · Computer Science 2025-04-01 Jonathan Peters , Philippe Talatchian

Systems coupled to multiple thermodynamic reservoirs can exhibit nonequilibrium dynamics, breaking detailed balance to generate currents. To power these currents, the entropy of the reservoirs increases. The rate of entropy production, or…

Statistical Mechanics · Physics 2019-04-16 Junang Li , Jordan M. Horowitz , Todd R. Gingrich , Nikta Fakhri

Bacteria often develop distinct phenotypes to adapt to environmental stress. In particular, they can produce biofilms, dense communities of bacteria that live in a complex extracellular matrix. Bacterial biofilms provide a safe haven from…

Quantitative Methods · Quantitative Biology 2025-08-29 Stephen Williams , Daravuth Cheam , Michele K. Nishiguchi , Suzanne S. Sindi , Shilpa Khatri , Erica M. Rutter

Error estimates of finite element methods for reaction-diffusion problems are often realised in the related energy norm. In the singularly perturbed case, however, this norm is not adequate. A different scaling of the $H^m$ seminorm for…

Numerical Analysis · Mathematics 2021-03-15 Sebastian Franz , Hans-G. Roos
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