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This article proposes a new method to estimate an existing mutual information based dependence measure using histogram density estimates. Finding a suitable bin length for histogram is an open problem. We propose a new way of computing the…

Information Theory · Computer Science 2015-09-15 Namita Jain , C. A. Murthy

Mutual Information (MI) is often used for feature selection when developing classifier models. Estimating the MI for a subset of features is often intractable. We demonstrate, that under the assumptions of conditional independence, MI…

Machine Learning · Computer Science 2017-06-26 Hemanth Venkateswara , Prasanth Lade , Binbin Lin , Jieping Ye , Sethuraman Panchanathan

Conditional independence testing (CIT) is a common task in machine learning, e.g., for variable selection, and a main component of constraint-based causal discovery. While most current CIT approaches assume that all variables are numerical…

Machine Learning · Computer Science 2023-11-07 Oana-Iuliana Popescu , Andreas Gerhardus , Jakob Runge

The selection of features that are relevant for a prediction or classification problem is an important problem in many domains involving high-dimensional data. Selecting features helps fighting the curse of dimensionality, improving the…

Machine Learning · Computer Science 2009-09-04 Michel Verleysen , Fabrice Rossi , Damien François

Mutual information (MI) is one of the most general ways to measure relationships between random variables, but estimating this quantity for complex systems is challenging. Denoising diffusion models have recently set a new bar for density…

Machine Learning · Computer Science 2025-11-20 Longxuan Yu , Xing Shi , Xianghao Kong , Tong Jia , Greg Ver Steeg

We consider the problem of estimating mutual information between dependent data, an important problem in many science and engineering applications. We propose a data-driven, non-parametric estimator of mutual information in this paper. The…

Information Theory · Computer Science 2017-03-08 Rakesh Malladi , Don H Johnson , Behnaam Aazhang

Estimating mutual information (MI) is a fundamental yet challenging task in data science and machine learning. This work proposes a new estimator for mutual information. Our main discovery is that a preliminary estimate of the data…

Machine Learning · Computer Science 2024-08-20 Yanzhi Chen , Zijing Ou , Adrian Weller , Yingzhen Li

Mutual information (MI) is a fundamental measure of statistical dependence between two variables, yet accurate estimation from finite data remains notoriously difficult. No estimator is universally reliable, and common approaches fail in…

Data Analysis, Statistics and Probability · Physics 2025-10-02 Eslam Abdelaleem , K. Michael Martini , Ilya Nemenman

The identification of compound-protein interactions (CPI) plays a critical role in drug screening, drug repurposing, and combination therapy studies. The effectiveness of CPI prediction relies heavily on the features extracted from both…

Biomolecules · Quantitative Biology 2023-06-16 Li Zhang , Wenhao Li , Haotian Guan , Zhiquan He , Mingjun Cheng , Han Wang

Experimentally observed networks of interacting dynamical systems are inferred from recorded multivariate time series by evaluating a statistical measure of dependence, usually the cross-correlation coefficient, or mutual information. These…

Data Analysis, Statistics and Probability · Physics 2017-07-03 Milan Palus

Mutual information (MI) is a general measure of statistical dependence with widespread application across the sciences. However, estimating MI between multi-dimensional variables is challenging because the number of samples necessary to…

Quantitative Methods · Quantitative Biology 2025-03-06 Gokul Gowri , Xiao-Kang Lun , Allon M. Klein , Peng Yin

We introduce a novel Mutual Information (MI) estimator that fundamentally reframes the discriminative approach. Instead of training a classifier to discriminate between joint and marginal distributions, we learn a normalizing flow that…

Machine Learning · Computer Science 2026-02-10 Ivan Butakov , Alexander Semenenko , Valeriya Kirova , Alexey Frolov , Ivan Oseledets

Purpose: Health recommenders act as important decision support systems, aiding patients and medical professionals in taking actions that lead to patients' well-being. These systems extract the information which may be of particular…

Machine Learning · Computer Science 2024-07-02 Abhishek Dey , Debayan Goswami , Rahul Roy , Susmita Ghosh , Yu Shrike Zhang , Jonathan H. Chan

Mutual Information (MI) is a fundamental metric for quantifying dependency between two random variables. When we can access only the samples, but not the underlying distribution functions, we can evaluate MI using sample-based estimators.…

Machine Learning · Statistics 2024-10-16 Kyungeun Lee , Wonjong Rhee

Reshef et al. recently proposed a new statistical measure, the "maximal information coefficient" (MIC), for quantifying arbitrary dependencies between pairs of stochastic quantities. MIC is based on mutual information, a fundamental…

Quantitative Methods · Quantitative Biology 2015-06-12 Justin B. Kinney , Gurinder S. Atwal

Learning representations that transfer well to diverse downstream tasks remains a central challenge in representation learning. Existing paradigms -- contrastive learning, self-supervised masking, and denoising auto-encoders -- balance this…

Machine Learning · Computer Science 2025-09-29 Micha Livne

Estimation of mutual information between random variables has become crucial in a range of fields, from physics to neuroscience to finance. Estimating information accurately over a wide range of conditions relies on the development of…

Methodology · Statistics 2018-11-14 Houman Safaai , Arno Onken , Christopher D. Harvey , Stefano Panzeri

Processed data are insightful, and crude data are obtuse. A serious threat to data reliability is missing values. Such data leads to inaccurate analysis and wrong predictions. We propose an efficient technique to impute the missing value in…

Machine Learning · Computer Science 2021-07-02 Prateek Mishra , Kumar Divya Mani , Prashant Johri , Dikhsa Arya

Mutual information is fundamentally important for measuring statistical dependence between variables and for quantifying information transfer by signaling and communication mechanisms. It can, however, be challenging to evaluate for…

Information Theory · Computer Science 2014-07-29 Clive G. Bowsher , Margaritis Voliotis

Feature selection is used to eliminate redundant features and keep relevant features, it can enhance machine learning algorithm's performance and accelerate computing speed. In various methods, mutual information has attracted increasingly…

Information Theory · Computer Science 2023-06-28 Gaoshuai Wang , Fabrice Lauri , Pu Wang , Hongyuan Luo , Amir Hajjam lL Hassani