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In single-particle cryo-electron microscopy (cryo-EM), the efficient determination of orientation parameters for 2D projection images poses a significant challenge yet is crucial for reconstructing 3D structures. This task is complicated by…

Image and Video Processing · Electrical Eng. & Systems 2025-09-30 Szu-Chi Chung

Multi-mode fibers provide an increased amount of data transfer rates given a large number of transmission modes. Unfortunately, the increased number of modes in a multi-mode fiber hinders the accurate transfer of information due to…

Optics · Physics 2023-02-16 Alim Yolalmaz , Emre Yüce

Although deep encoder-decoder networks have achieved astonishing performance for mitochondria segmentation from electron microscopy (EM) images, they still produce coarse segmentations with lots of discontinuities and false positives.…

Computer Vision and Pattern Recognition · Computer Science 2020-01-30 Zhimin Yuan , Jiajin Yi , Zhengrong Luo , Zhongdao Jia , Jialin Peng

Semantic segmentation of electron microscopy (EM) is an essential step to efficiently obtain reliable morphological statistics. Despite the great success achieved using deep convolutional neural networks (CNNs), they still produce coarse…

Computer Vision and Pattern Recognition · Computer Science 2021-01-11 Zhimin Yuan , Xiaofen Ma , Jiajin Yi , Zhengrong Luo , Jialin Peng

Machine learning, and more specifically deep learning, have shown remarkable performance in sensing, communications, and inference. In this paper, we consider the application of the deep unfolding technique in the problem of signal…

Signal Processing · Electrical Eng. & Systems 2019-04-23 Shahin Khobahi , Naveed Naimipour , Mojtaba Soltanalian , Yonina C. Eldar

We report the development of deep learning coherent electron diffractive imaging at sub-angstrom resolution using convolutional neural networks (CNNs) trained with only simulated data. We experimentally demonstrate this method by applying…

Materials Science · Physics 2022-04-19 Dillan J. Chang , Colum M. O'Leary , Cong Su , Salman Kahn , Alex Zettl , Jim Ciston , Peter Ercius , Jianwei Miao

Holographic displays have significant potential in virtual reality and augmented reality owing to their ability to provide all the depth cues. Deep learning-based methods play an important role in computer-generated holography (CGH). During…

Optics · Physics 2025-11-11 Shuyang Xie , Jie Zhou , Bo Xu , Jun Wang , Renjing Xu

Recording atomic-resolution transmission electron microscopy (TEM) images is becoming increasingly routine. A new bottleneck is then analyzing this information, which often involves time-consuming manual structural identification. We have…

Under extreme operating conditions, characterized by high particle multiplicity and heavily overlapping shower energy deposits, classical particle flow algorithms encounter pronounced limitations in resolution, efficiency, and accuracy. To…

Instrumentation and Detectors · Physics 2025-05-13 Yu Wang , Yangguang Zhang , Shengxiang Lin , Xingyi Zhang , Han Zhang

Limited-angle electron tomography aims to reconstruct 3D shapes from 2D projections of Transmission Electron Microscopy (TEM) within a restricted range and number of tilting angles, but it suffers from the missing-wedge problem that causes…

Computer Vision and Pattern Recognition · Computer Science 2026-05-05 Zhantao Deng , Mériem Er-Rafik , Anna Sushko , Cécile Hébert , Pascal Fua

Machine learning is attracting surging interest across nearly all scientific areas by enabling the analysis of large datasets and the extraction of scientific information from incomplete data. Data-driven science is rapidly growing,…

Applied Physics · Physics 2025-03-17 Sung Yun Lee , Do Hyung Cho , Chulho Jung , Daeho Sung , Daewoong Nam , Sangsoo Kim , Changyong Song

We show that de-focused single particle images recorded using a cryo-electron microscope (cryoEM) system may be processed like a Fresnel zone in-line hologram to obtain physically meaningful quantitative phase maps associated with…

Image and Video Processing · Electrical Eng. & Systems 2021-11-24 Apoorv Pant , Manidipa Banerjee , Kedar Khare

Photomultiplier tubes (PMTs) are widely employed in particle and nuclear physics experiments. The accuracy of PMT waveform reconstruction directly impacts the detector's spatial and energy resolution. A key challenge arises when multiple…

High Energy Physics - Experiment · Physics 2026-02-06 Kainan Liu , Jingyu Huang , Guihong Huang , Jianyi Luo

Finite element methods (FEM) are popular approaches for simulation of soft tissues with elastic or viscoelastic behavior. However, their usage in real-time applications, such as in virtual reality surgical training, is limited by…

Machine Learning · Computer Science 2023-01-12 Mohammad Karami , Hervé Lombaert , David Rivest-Hénault

To study the fundamental physics of complex multiphase flow systems using advanced measurement techniques, especially the electrical capacitance tomography (ECT) approach, this article carries out an initial literature review of the ECT…

Computer Vision and Pattern Recognition · Computer Science 2015-10-16 Kezhi Li

Cryo-electron microscopy (cryo-EM) has revolutionized structural biology by enabling near-atomic-level visualization of biomolecular assemblies. However, the exponential growth in cryo-EM data throughput and complexity, coupled with diverse…

Quantitative Methods · Quantitative Biology 2026-02-25 Weining Fu , Kai Shu , Kui Xu , Qiangfeng Cliff Zhang

Ultrafast lasers ($< 500$ fs) have enabled laser-matter interactions at intensities exceeding $10^{18} \rm{Wcm}^{-2}$ with only millijoules of laser energy. However, as pulse durations become shorter, larger spectral bandwidths are…

Recently, digital holographic imaging techniques (including methods with heterodyne detection) have found increased attention in the terahertz (THz) frequency range. However, holographic techniques rely on the use of a reference beam in…

Optics · Physics 2022-12-14 Mingjun Xiang , Hui Yuan , Lingxiao Wang , Kai Zhou , Hartmut G. Roskos

In Europe the 20% of the CT scans cover the thoracic region. The acquired images contain information about the cardiovascular system that often remains latent due to the lack of contrast in the cardiac area. On the other hand, the contrast…

Computer Vision and Pattern Recognition · Computer Science 2018-07-06 Gianmarco Santini , Lorena M. Zumbo , Nicola Martini , Gabriele Valvano , Andrea Leo , Andrea Ripoli , Francesco Avogliero , Dante Chiappino , Daniele Della Latta

Lorentz transmission electron microscopy is a unique characterization technique that enables the simultaneous imaging of both the microstructure and functional properties of materials at high spatial resolution. The quantitative information…

Materials Science · Physics 2020-12-09 Tao Zhou , Mathew Cherukara , Charudatta Phatak