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Diffusion-weighted (DW) magnetic resonance spectroscopy (MRS) suffers from a lower signal to noise ratio (SNR) compared to conventional MRS owing to the addition of diffusion attenuation. This technique can therefore strongly benefit from…

Medical Physics · Physics 2023-02-13 Jessie Mosso , Dunja Simicic , Cristina Cudalbu , Ileana O. Jelescu

Functional Magnetic Resonance Imaging (fMRI) is a non-invasive technique for studying brain activity. During an fMRI session, the subject executes a set of tasks (task-related fMRI study) or no tasks (resting-state fMRI), and a sequence of…

Image and Video Processing · Electrical Eng. & Systems 2023-10-10 Christos Theodoropoulos , Christos Chatzichristos , Sabine Van Huffel

MP-PCA denoising has become the method of choice for denoising in MRI since it provides an objective threshold to separate the desired signal from unwanted thermal noise components. In rodents, thermal noise in the coils is an important…

Medical Physics · Physics 2022-11-29 Francisca F. Fernandes , Jonas L. Olesen , Sune N. Jespersen , Noam Shemesh

Resting state fMRI (rsfMRI) has been shown to be a promising tool to study intrinsic functional connectivity and assess its integrity in cerebral development. In neonates, where fMRI is limited to few paradigms, rsfMRI was shown to be a…

Image and Video Processing · Electrical Eng. & Systems 2022-04-12 V. Enguix , J. Kenley , D. Luck , J. Cohen-Adad , G. A. Lodygensky

Proton magnetic resonance spectroscopic imaging (1H-MRSI) is a powerful tool that enables the multidimensional non-invasive mapping of the neurochemical profile at high-resolution over the entire brain. The constant demand for higher…

Random matrix theory (RMT) combined with principal component analysis has resulted in a widely used MPPCA noise mapping and denoising algorithm, that utilizes the redundancy in multiple acquisitions and in local image patches. RMT-based…

Magnetic resonance imaging (MRI) is a non-invasive medical imaging technique offering high-resolution 3D images and valuable insights into human tissue conditions. Even at present, the refinement of denoising methods for MRI remains a…

Image and Video Processing · Electrical Eng. & Systems 2023-08-29 Shiao Li

Functional Magnetic Resonance Images acquired during resting-state provide information about the functional organization of the brain through measuring correlations between brain areas. Independent components analysis is the reference…

Neurons and Cognition · Quantitative Biology 2014-12-15 Alexandre Abraham , Elvis Dohmatob , Bertrand Thirion , Dimitris Samaras , Gael Varoquaux

PURPOSE: Multi-exponential relaxometry is a powerful tool for characterizing tissue, but generally requires high image signal-to-noise ratio (SNR). This work evaluates the use of principal-component-analysis (PCA) denoising to mitigate…

The signal to noise ratio (SNR) fundamentally limits the information accessible by magnetic resonance imaging (MRI). This limitation has been addressed by a host of denoising techniques, recently including so-called MPPCA: Principal…

Medical Physics · Physics 2022-10-18 Jonas L. Olesen , Andrada Ianus , Leif Østergaard , Noam Shemesh , Sune N. Jespersen

Quantitative Susceptibility Mapping (QSM) is a technique for measuring magnetic susceptibility of tissues, aiding in the detection of pathologies like traumatic brain injury and multiple sclerosis by analyzing variations in substances such…

Quantitative Methods · Quantitative Biology 2025-06-05 Liad Doniza , Mitchel Lee , Tamar Blumenfeld Katzir , Moran Artzi , Dafna Ben Bashat , Dvir Radunsky , Karin Shmueli , Noam Ben-Eliezer

Big data initiatives such as the Enhancing NeuroImaging Genetics through Meta-Analysis consortium (ENIGMA), combine data collected by independent studies worldwide to achieve more accurate estimates of effect sizes and more reliable and…

For neurological disorders and diseases, functional and anatomical connectomes of the human brain can be used to better inform targeted interventions and treatment strategies. Functional magnetic resonance imaging (fMRI) is a non-invasive…

Methodology · Statistics 2023-07-03 Matt Ryan , Gary Glonek , Jono Tuke , Melissa Humphries

As machine learning continues to gain momentum in the neuroscience community, we witness the emergence of novel applications such as diagnostics, characterization, and treatment outcome prediction for psychiatric and neurological disorders,…

Computer Vision and Pattern Recognition · Computer Science 2018-04-27 Maxim Sharaev , Alexander Andreev , Alexey Artemov , Alexander Bernstein , Evgeny Burnaev , Ekaterina Kondratyeva , Svetlana Sushchinskaya , Renat Akzhigitov

Head motion during functional Magnetic Resonance Imaging acquisition can significantly contaminate the neural signal and introduce spurious, distance-dependent changes in signal correlations. This can heavily confound studies of…

Image and Video Processing · Electrical Eng. & Systems 2020-01-23 Vyom Raval , Kevin P. Nguyen , Albert Montillo

We propose a novel denoising framework for task functional Magnetic Resonance Imaging (tfMRI) data to delineate the high-resolution spatial pattern of the brain functional connectivity via dictionary learning and sparse coding (DLSC). In…

Machine Learning · Computer Science 2017-07-24 Seongah Jeong , Xiang Li , Jiarui Yang , Quanzheng Li , Vahid Tarokh

We present a computational framework for analysis and visualization of non-linear functional connectivity in the human brain from resting state functional MRI (fMRI) data for purposes of recovering the underlying network community structure…

Neural and Evolutionary Computing · Computer Science 2014-07-16 Axel Wismüller , Xixi Wang , Adora M. DSouza , Mahesh B. Nagarajan

Resting-state functional MRI (rs-fMRI) is a rich imaging modality that captures spontaneous brain activity patterns, revealing clues about the connectomic organization of the human brain. While many rs-fMRI studies have focused on static…

Machine Learning · Computer Science 2019-08-20 Meenakshi Khosla , Keith Jamison , Amy Kuceyeski , Mert R. Sabuncu

Functional connectivity estimates are highly sensitive to analysis choices and can be dominated by noise when the number of sampled time points is small relative to network dimensionality. This issue is particularly acute in fMRI, where…

Disordered Systems and Neural Networks · Physics 2026-02-10 Izaro Fernandez-Iriondo , Antonio Jimenez-Marin , Jesus Cortes , Pablo Villegas

Censoring high-motion volumes in fMRI is common practice to reduce effects of head motion on functional connectivity (FC). Although aggressive censoring removes more noise, it causes extensive data loss, creating a tradeoff that may…

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