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Conformation generation, also known as molecular unfolding (MU), is a crucial step in structure-based drug design, remaining a challenging combinatorial optimization problem. Quantum annealing (QA) has shown great potential for solving…

We have developed a quantum annealing processor, based on an array of tunably coupled rf-SQUID flux qubits, fabricated in a superconducting integrated circuit process [1]. Implementing this type of processor at a scale of 512 qubits and…

Quantum annealing has great promise in leveraging quantum mechanics to solve combinatorial optimisation problems. However, to realize this promise to it's fullest extent we must appropriately leverage the underlying physics. In this spirit,…

Quantum Physics · Physics 2020-12-10 Nicholas Chancellor

Quantum annealing is a method developed to solve combinatorial optimization problems by utilizing quantum bits. Solving such problems corresponds to minimizing a cost function defined over binary variables. However, in many practical cases,…

Quantum Physics · Physics 2025-06-26 Seiya Endo , Shohei Kawakatsu , Hiromichi Matsuyama , Kohei Suzuki , Yuichiro Matsuzaki

Fully tunable flux qubits offer in-situ and independent controls of their energy potential asymmetry and tunnel barrier, making them versatile tools for quantum computation and the study of decoherence sources. However, only short coherence…

Quantum annealing (QA) is a method for solving combinatorial optimization problems. We can estimate the computational time for QA using the adiabatic condition. The adiabatic condition consists of two parts: an energy gap and a transition…

Quantum Physics · Physics 2024-08-28 Hiroshi Hayasaka , Takashi Imoto , Yuichiro Matsuzaki , Shiro Kawabata

We introduce a novel Simulated Quantum Annealing (SQA) algorithm which employs a multispin quantum fluctuation operator. At variance with the usual transverse field, short-range two-spin flip interactions are included in the driver…

Quantum Physics · Physics 2017-05-24 Guglielmo Mazzola , Matthias Troyer

Superconducting flux qubits are promising candidates for the physical realization of a scalable quantum processor. Indeed, these circuits may have both a small decoherence rate and a large anharmonicity. These properties enable the…

Mesoscale and Nanoscale Physics · Physics 2022-07-05 T. Chang , I. Holzman , T. Cohen , B. C. Johnson , D. N. Jamieson , M. Stern

We introduce Simulated Bifurcation Quantum Annealing (SBQA), a quantum-inspired optimization algorithm that extends simulated bifurcation by incorporating inter-replica interactions to mimic quantum tunneling. SBQA retains the efficiency…

Quantum Physics · Physics 2026-04-08 Jakub Pawłowski , Paweł Tarasiuk , Jan Tuziemski , Łukasz Pawela , Bartłomiej Gardas

Quantum annealing (QA) is a generic method for solving optimization problems using fictitious quantum fluctuation. The current device performing QA involves controlling the transverse field; it is classically simulatable by using the…

Disordered Systems and Neural Networks · Physics 2019-05-01 Masayuki Ohzeki

Quantum annealing machines based on superconducting qubits, which have the potential to solve optimization problems faster than digital computers, are of great interest not only to researchers but also to the general public. Here, we…

Quantum Physics · Physics 2018-10-22 T. Tanamoto , Y. Higashi , T. Marukame , J. Deguchi

Quantum annealing (QA) and Quantum Alternating Operator Ansatz (QAOA) are both heuristic quantum algorithms intended for sampling optimal solutions of combinatorial optimization problems. In this article we implement a rigorous direct…

Quantum Physics · Physics 2023-08-31 Elijah Pelofske , Andreas Bärtschi , Stephan Eidenbenz

In this dissertation, we explore how quantum annealing (QA) and its applications behave in an open system setting. We give derivations and numerical recipes for effective parallel simulation methods for time-dependent open dynamics of…

Quantum Physics · Physics 2021-07-16 Ka Wa Yip

Quantum annealing is a powerful alternative model for quantum computing, which can succeed in the presence of environmental noise even without error correction. However, despite great effort, no conclusive proof of a quantum speedup…

Quantum Physics · Physics 2023-04-03 Eliot Kapit , Vadim Oganesyan

Quantum annealing method has been widely attracted attention in statistical physics and information science since it is expected to be a powerful method to obtain the best solution of optimization problem as well as simulated annealing. The…

Disordered Systems and Neural Networks · Physics 2017-08-23 Shu Tanaka , Ryo Tamura

In recent years, quantum computing has promised a revolution in computing performance, based on massive parallelism enabled by many entangled qubits. Josephson junction integrated circuits have emerged as the key technology to implement…

Superconductivity · Physics 2014-08-26 Alan M. Kadin , Steven B. Kaplan

We evaluate the application of quantum annealing (QA) to a real-world combinatorial optimisation problem-room scheduling for sports camps at the Australian Institute of Sport-using both classical and quantum approaches. Due to current…

Quantum Physics · Physics 2025-09-08 Krzysztof Giergiel , Y. Sam Yang , Anthony B. Murphy

Quantum annealing (QA) is a hardware-based heuristic optimization and sampling method applicable to discrete undirected graphical models. While similar to simulated annealing, QA relies on quantum, rather than thermal, effects to explore…

Quantum computing is an important developing technology with the potential to revolutionise the landscape of scientific and business problems that can be practically addressed. The widespread excitement derives from the potential for a…

Quantum Physics · Physics 2022-11-24 R. Cumming , T. Thomas

Quantum algorithm design usually assumes access to a perfect quantum computer with ideal properties like full connectivity, noise-freedom and arbitrarily long coherence time. In Noisy Intermediate-Scale Quantum (NISQ) devices, however, the…

Quantum Physics · Physics 2020-09-11 Xiangzhen Zhou , Sanjiang Li , Yuan Feng