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Related papers: Nonlinear control in the nematode C. elegans

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Understanding how neural dynamics shape cognitive experiences remains a central challenge in neuroscience and psychiatry. Here, we present a novel framework leveraging state-to-output controllability from dynamical systems theory to model…

What fascinates us about animal behavior is its richness and complexity, but understanding behavior and its neural basis requires a simpler description. Traditionally, simplification has been imposed by training animals to engage in a…

Neurons and Cognition · Quantitative Biology 2016-07-13 Greg J. Stephens , Leslie C. Osborne , William Bialek

We present a random walk model that exhibits asymptotic subdiffusive, diffusive, and superdiffusive behavior in different parameter regimes. This appears to be the first instance of a single random walk model leading to all three forms of…

Mathematical Physics · Physics 2015-05-19 Niraj Kumar , Upendra Harbola , Katja Lindenberg

Connectomics has focused primarily on the mapping of synaptic links in the brain; yet it is well established that extrasynaptic volume transmission, especially via monoamines and neuropeptides, is also critical to brain function. Here we…

Neurons and Cognition · Quantitative Biology 2017-02-08 Barry Bentley , Robyn Branicky , Christopher L. Barnes , Edward T. Bullmore , Petra E. Vértes , William R. Schafer

An increasing number of complex systems are now modeled as networks of coupled dynamical entities. Nonlinearity and high-dimensionality are hallmarks of the dynamics of such networks but have generally been regarded as obstacles to control.…

Disordered Systems and Neural Networks · Physics 2015-12-07 Adilson E. Motter

The concept of control is crucial for effectively understanding and applying biological network models. Key structural features relate to control functions through gene regulation, signaling, or metabolic mechanisms, and computational…

Molecular Networks · Quantitative Biology 2024-11-05 David Murrugarra , Alan Veliz-Cuba , Elena Dimitrova , Claus Kadelka , Matthew Wheeler , Reinhard Laubenbacher

Human learning is a complex phenomenon requiring flexibility to adapt existing brain function and precision in selecting new neurophysiological activities to drive desired behavior. These two attributes -- flexibility and selection -- must…

Neurons and Cognition · Quantitative Biology 2013-06-28 Danielle S. Bassett , Nicholas F. Wymbs , Mason A. Porter , Peter J. Mucha , Jean M. Carlson , Scott T. Grafton

The ability to manipulate and control fluid flows is of great importance in many scientific and engineering applications. Here, a cluster-based control framework is proposed to determine optimal control laws with respect to a cost function…

Fluid Dynamics · Physics 2016-02-18 Eurika Kaiser , Bernd R. Noack , Andreas Spohn , Louis N. Cattafesta , Marek Morzynski

Effective control of biological systems can often be achieved through the control of a surprisingly small number of distinct variables. We bring clarity to such results using the formalism of Boolean dynamical networks, analyzing the…

Molecular Networks · Quantitative Biology 2021-09-13 Enrico Borriello , Bryan C. Daniels

This work concerns a many-body deterministic model that displays life-like properties as emergence, complexity, self-organization, spontaneous compartmentalization, and self-regulation. The model portraits the dynamics of an ensemble of…

Adaptation and Self-Organizing Systems · Physics 2023-07-11 Alessandro Scirè , Valerio Annovazzi-Lodi

We propose a novel discrete model of central pattern generators (CPG), neuronal ensembles generating rhythmic activity. The model emphasizes the role of nonsynaptic interactions and the diversity of electrical properties in nervous systems.…

Neural and Evolutionary Computing · Computer Science 2017-05-10 Nikolay Bazenkov , Varvara Dyakonova , Oleg Kuznetsov , Dmitri Sakharov , Dmitry Vorontsov , Liudmila Zhilyakova

Sensitivity analysis is an effective tool for systematically identifying specific perturbations in parameters that have significant effects on the behavior of a given biosystem, at the scale investigated. In this work, using a…

Quantitative Methods · Quantitative Biology 2007-12-04 Zhihui Wang , Christina M. Birch , Thomas S. Deisboeck

Similar activity patterns may arise from model neural networks with distinct coupling properties and individual unit dynamics. These similar patterns may, however, respond differently to parameter variations and, specifically, to tuning of…

Neurons and Cognition · Quantitative Biology 2023-06-16 Zhuojun Yu , Jonathan E. Rubin , Peter J. Thomas

We demonstrate, both analytically and numerically, that learning dynamics of neural networks is generically attracted towards a self-organized critical state. The effect can be modeled with quartic interactions between non-trainable…

Statistical Mechanics · Physics 2021-07-09 Mikhail I. Katsnelson , Vitaly Vanchurin , Tom Westerhout

Activity or spin patterns on random scale-free network are studied by mean field analysis and computer simulations. These activity patterns evolve in time according to local majority-rule dynamics which is implemented using (i) parallel or…

Disordered Systems and Neural Networks · Physics 2007-05-23 Haijun Zhou , Reinhard Lipowsky

For the hopping dynamics in a one-dimensional model, containing energy and barrier disorder, we determine the linear and nonlinear response to an external field for arbitrary external frequencies. The calculation is performed in analytical…

Disordered Systems and Neural Networks · Physics 2013-02-15 Clara Mattner , Bernhard Roling , Andreas Heuer

Mammals can generate autonomous behaviors in various complex environments through the coordination and interaction of activities at different levels of their central nervous system. In this paper, we propose a novel hierarchical learning…

Robotics · Computer Science 2024-08-08 Pei Zhang , Zhaobo Hua , Jinliang Ding

We propose a dynamical neural network model with a hierarchical and modular structure. The network architecture can be derived by minimizing an energy function that is originally designed based on two kinds of neurons with quite different…

Neurons and Cognition · Quantitative Biology 2026-04-14 Kazuyoshi Tsutsumi , Ernst Niebur

We demonstrate a spiking neural network for navigation motivated by the chemotaxis network of Caenorhabditis elegans. Our network uses information regarding temporal gradients in the tracking variable's concentration to make navigational…

Neural and Evolutionary Computing · Computer Science 2014-10-30 Shibani Santurkar , Bipin Rajendran

We propose a hierarchically modular, dynamical neural network model whose architecture minimizes a specifically designed energy function and defines its temporal characteristics. The model has an internal and an external space that are…

Neurons and Cognition · Quantitative Biology 2026-04-16 Kazuyoshi Tsutsumi , Ernst Niebur