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We describe Structured Random Binding (SRB), a minimal model of protein-protein interactions rooted in the statistical physics of disordered systems. In this model, nonspecific binding is a generic consequence of the interaction between…

Statistical Mechanics · Physics 2025-03-27 Ling-Nan Zou

In a single-particle detection experiment, a wavefront impinges on a detector but observers only see a point response. The extent of the wavefront becomes evident only in statistical accumulation of many independent detections, with…

Quantum Physics · Physics 2017-06-26 Jonathan F. Schonfeld

The binomial acceptance correction procedure is studied for particle number distributions detected in high energy reactions in finite regions of the momentum space. We present acceptance correction formulas for scaled variance, skewness,…

High Energy Physics - Phenomenology · Physics 2020-03-25 Oleh Savchuk , Roman V. Poberezhnyuk , Volodymyr Vovchenko , Mark I. Gorenstein

Probabilities to find a chosen number of electrons in flexible domains of space are calculated for highly correlated wave functions. Quantum mechanics can produce higher probabilities for chemically relevant arrangements of electrons in…

Chemical Physics · Physics 2022-06-29 Anthony Scemama , Andreas Savin

Recently Smit et al. [Nature 419, 906 (2002)] have reported that a single hydrogen molecule can form a bridge between Pt electrodes, which has a conductance close to one quantum unit, carried by a single channel. We present density…

Mesoscale and Nanoscale Physics · Physics 2007-05-23 J. Heurich , F. Pauly , J. C. Cuevas , W. Wenzel , Gerd Schoen

We present a computational scheme for predicting the ligands that bind to a pocket of known structure. It is based on the generation of a general abstract representation of the molecules, which is invariant to rotations, translations and…

Chemical Physics · Physics 2024-05-09 R. Beccaria , A. Lazzeri , G. Tiana

Traditionally, it is understood that fluctuations in the equilibrium distribution are not evident in thermodynamic systems of large $N$ (the number of particles in the system) \cite{Huang1}. In this paper we examine the validity of this…

Mathematical Physics · Physics 2007-10-03 Kieran Kelly , Przemysław Repetowicz , Seosamh macRéamoinn

Randomness is viewed through an analogy between a physical quantity, density of gas, and a mathematical construct -- probability density. Boltzmann's deduction of equilibrium distribution of ideal gas placed in an external potential field…

Probability · Mathematics 2012-08-27 M. Grendar, , M. Grendar

The formation and dissociation of specific noncovalent interactions between a variety of macromolecules play a crucial role in the function of biological systems. During the last few years, three main lines of research led to a dramatic…

Biological Physics · Physics 2009-11-13 Pierre Bongrand

We introduce the two-particle probability density $X(x)$ of $x=\bm{r}_{12}\cdot\bm{p}_{12}=\left(\bm{r}_1-\bm{r}_2\right) \cdot \left(\bm{p}_1-\bm{p}_2\right)$. We show how to derive $X(x)$, which we call the Posmom intracule, from the…

Chemical Physics · Physics 2015-06-12 Yves A. Bernard , Pierre-Francçois Loos , Peter M. W. Gill

We consider the problem of inferring the probability distribution of flux configurations in metabolic network models from empirical flux data. For the simple case in which experimental averages are to be retrieved, data are described by a…

Molecular Networks · Quantitative Biology 2017-04-27 Daniele De Martino , Andrea De Martino

The study of "random segments" is a classic issue in geometrical probability, whose complexity depends on how it is defined. But in apparently simple models, the random behavior is not immediate. In the present manuscript the following…

Probability · Mathematics 2023-09-07 Paulo Manrique-Mirón

The linear Boltzmann equation for elastic and/or inelastic scattering is applied to derive the distribution function of a spatially homogeneous system of charged particles spreading in a host medium of two-level atoms and subjected to…

Statistical Mechanics · Physics 2009-11-13 A. Rossani , A. M. Scarfone

Within the framework of the random distribution assumption of cyclic bonds, the theory of gelation is extended to mixing systems of the R-Ag + R-Bf-g model, which is expected to have wider application such as micell formations in biological…

Soft Condensed Matter · Physics 2007-05-23 Kazumi Suematsu

Quark deconfinement phase transition at finite temperature and density is investigated in the frame of quantum mechanics. By solving the Schr\"odinger equation for a heavy quark in a thermal mean field, we calculate the quark probability…

High Energy Physics - Phenomenology · Physics 2007-05-23 Lianyi He , Guang Bian , Jinfeng Liao , Pengfei Zhuang

We consider diatomic systems in which the kinetic energy of the electrons is treated in a simple relativistic model. The Born-Oppenheimer approximation is assumed. We investigate questions of stability, deducing bounds on the number $N$ of…

Mathematical Physics · Physics 2015-05-18 Natalie Gilka

Ligand receptor interactions are commonly assessed through equilibrium occupancy and pharmacodynamic measures that describe binding and saturation by means of bounded response curves. Thermodynamic approaches relate binding affinity to…

Other Quantitative Biology · Quantitative Biology 2026-05-19 Arturo Tozzi

It is shown that the probability density satisfies a hyperbolic equation of motion with the unique characteristic that in its many-particle form it contains derivatives acting at spatially remote regions. Based on this feature we explore…

Quantum Physics · Physics 2024-09-20 C Dedes

Finite mixture models are fitted to spherical data. Kent distributions are used for the components of the mixture because they allow considerable flexibility. Previous work on such mixtures has used an approximate maximum likelihood…

Statistics Theory · Mathematics 2021-04-28 Kanti V. Mardia , Stuart Barber , Philippa M. Burdett , John T. Kent , Thomas Hamelryck

The partition function of nonequilibrium distribution which we recently obtained [arXiv:0802.0259] in the framework of the maximum isotropization model (MIM) is exploited to extract physical information from experimental data on the proton…

Nuclear Theory · Physics 2008-04-11 Dmitry Anchishkin , Stanislav Yezhov