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Advances in spatial transcriptomics (ST) technologies enable systematic molecular characterization of tumor microenvironment, tumor gradients and gene regulatory networks. Cancer progression is known to vary along pathological gradients,…
To be feasible for computationally intensive applications such as parametric studies, optimization and control design, large-scale finite element analysis requires model order reduction. This is particularly true in nonlinear settings that…
Stochastic gradient descent (SGD) is a widely adopted iterative method for optimizing differentiable objective functions. In this paper, we propose and discuss a novel approach to scale up SGD in applications involving non-convex functions…
This paper addresses the optimization problem of minimizing non-convex continuous functions, which is relevant in the context of high-dimensional machine learning applications characterized by over-parametrization. We analyze a randomized…
The concept of Gaussian process tomography along with nonnegative constraints is applied in the context of high-resolution image reconstruction using segmented planar detectors with few readout channels.Expanding on the concept of 2-D…
Stochastic gradient-based optimization is crucial to optimize neural networks. While popular approaches heuristically adapt the step size and direction by rescaling gradients, a more principled approach to improve optimizers requires…
In recent years, random subspace methods have been actively studied for large-dimensional nonconvex problems. Recent subspace methods have improved theoretical guarantees such as iteration complexity and local convergence rate while…
We address the problem of reconstructing X-Ray tomographic images from scarce measurements by interpolating missing acquisitions using a self-supervised approach. To do so, we train shallow neural networks to combine two neighbouring…
We introduce a two-level trust-region method (TLTR) for solving unconstrained nonlinear optimization problems. Our method uses a composite iteration step, which is based on two distinct search directions. The first search direction is…
This work investigates a two-stage method for constructing projection-based reduced-order models (ROMs) of parameterized partial differential equations (PDEs). Based on established tensorial ROM methodology, the proposed approach reduces…
This paper studies stability and symmetry preserving $H^2$ optimal model reduction problems of linear systems which include linear gradient systems as a special case. The problem is formulated as a nonlinear optimization problem on the…
Search is a key service within constraint programming systems, and it demands the restoration of previously accessed states during the exploration of a search tree. Restoration proceeds either bottom-up within the tree to roll back…
In this work we investigate the practicality of stochastic gradient descent and recently introduced variants with variance-reduction techniques in imaging inverse problems. Such algorithms have been shown in the machine learning literature…
Accurate reconstruction of latent environmental fields from sparse and indirect observations is a foundational challenge across scientific domains-from atmospheric science and geophysics to public health and aerospace safety. Traditional…
In distributed second order optimization, a standard strategy is to average many local estimates, each of which is based on a small sketch or batch of the data. However, the local estimates on each machine are typically biased, relative to…
Reduced Order Modeling is of paramount importance for efficiently inferring high-dimensional spatio-temporal fields in parametric contexts, enabling computationally tractable parametric analyses, uncertainty quantification and control.…
This paper considers an explicit continuation method and the trust-region updating strategy for the unconstrained optimization problem. Moreover, in order to improve its computational efficiency and robustness, the new method uses the…
Compressed Sensing MRI (CS-MRI) has shown promise in reconstructing under-sampled MR images, offering the potential to reduce scan times. Classical techniques minimize a regularized least-squares cost function using an expensive iterative…
We propose a higher-order dimensionality reduction framework based on the Trace Ratio (TR) optimization problem. We establish conditions for existence and uniqueness of solutions and clarify the theoretical connection between the Trace…
English: This paper concerns the image reconstruction from a few projections in Computed Tomography (CT). The main objective of this paper is to show that the problem is so ill posed that no classical method, such as analytical methods…