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After a brief review of recent advances in sequential analysis involving sequential generalized likelihood ratio tests, we discuss their use in psychometric testing and extend the asymptotic optimality theory of these sequential tests to…

Methodology · Statistics 2025-01-08 Jay Bartroff , Matthew Finkelman , Tze Leung Lai

In this paper, we propose a novel element-wise subset selection method for the alternating least squares (ALS) algorithm, focusing on low-rank matrix factorization involving matrices with missing values, as commonly encountered in…

Methodology · Statistics 2025-11-12 Dunyao Xue , Mengyu Li , Cheng Meng , Jingyi Zhang

One common strategy for improving the performance of Large Language Models (LLMs) on downstream tasks involves using a \emph{verifier model} to either select the best answer from a pool of candidates or to steer the auto-regressive…

Artificial Intelligence · Computer Science 2025-09-26 Theo Uscidda , Matthew Trager , Michael Kleinman , Aditya Chattopadhyay , Wei Xia , Stefano Soatto

In the management of most chronic conditions characterized by the lack of universally effective treatments, adaptive treatment strategies (ATSs) have been growing in popularity as they offer a more individualized approach, and sequential…

Methodology · Statistics 2021-08-03 Armando Turchetta , Erica E. M. Moodie , David A. Stephens , Sylvie D. Lambert

Clinical trials often collect data on multiple outcomes, such as overall survival (OS), progression-free survival (PFS), and response to treatment (RT). In most cases, however, study designs only use primary outcome data for interim and…

Applications · Statistics 2026-04-28 Massimiliano Russo , Steffen Ventz , Lorenzo Trippa

We consider the problem of simultaneous detection and estimation under a sequential framework. In particular we are interested in sequential tests that distinguish between the null and the alternative hypothesis and every time the decision…

Statistics Theory · Mathematics 2013-09-24 Yasin Yilmaz , George V. Moustakides , Xiaodong Wang

The design of biological systems is hindered by uncertainty arising from both intrinsic stochasticity of biomolecular reactions and variability across laboratory or experimental conditions. In this work, we present a sequential framework to…

Machine Learning · Computer Science 2026-05-08 Michal Kobiela , Diego A. Oyarzún , Michael U. Gutmann

Computerized adaptive testing (CAT) is a form of personalized testing that accurately measures students' knowledge levels while reducing test length. Bilevel optimization-based CAT (BOBCAT) is a recent framework that learns a data-driven…

Computers and Society · Computer Science 2023-05-31 Wanyong Feng , Aritra Ghosh , Stephen Sireci , Andrew S. Lan

This paper studies the problem of high-dimensional multiple testing and sparse recovery from the perspective of sequential analysis. In this setting, the probability of error is a function of the dimension of the problem. A simple…

Statistics Theory · Mathematics 2011-06-06 Matthew Malloy , Robert Nowak

Accelerated degradation tests are used to provide accurate estimation of lifetime characteristics of highly reliable products within a relatively short testing time. Data from particular tests at high levels of stress (e.g., temperature,…

Applications · Statistics 2021-06-07 Helmi Shat , Rainer Schwabe

Group sequential designs drive innovation in clinical, industrial, and corporate settings. Early stopping for failure in sequential designs conserves experimental resources, whereas early stopping for success accelerates access to improved…

Methodology · Statistics 2025-11-27 Luke Hagar , Shirin Golchi , Marina B. Klein

Item Response Theory (IRT) is a ubiquitous model for understanding humans based on their responses to questions, used in fields as diverse as education, medicine and psychology. Large modern datasets offer opportunities to capture more…

Machine Learning · Computer Science 2020-03-17 Mike Wu , Richard L. Davis , Benjamin W. Domingue , Chris Piech , Noah Goodman

Innovation in synthetic biology often still depends on large-scale experimental trial-and-error, domain expertise, and ingenuity. The application of rational design engineering methods promise to make this more efficient, faster, cheaper…

Molecular Networks · Quantitative Biology 2021-08-18 Robyn P. Araujo , Sean T. Vittadello , Michael P. H. Stumpf

Interval censoring occurs when event times are only known to fall between scheduled assessments, a common design in clinical trials, epidemiology, and reliability studies. Standard right-censoring methods, such as Kaplan-Meier and Cox…

Methodology · Statistics 2025-09-04 J. T. Korley

Participants in online experiments often enroll over time, which can compromise sample representativeness due to temporal shifts in covariates. This issue is particularly critical in A/B tests, online controlled experiments extensively used…

General Economics · Economics 2026-03-30 Chen Wang , Shichao Han , Shan Huang

Increased access to computing resources has led to the development of algorithms that can run efficiently on multi-core processing units or in distributed computing environments. In the context of Bayesian inference, many parallel computing…

Methodology · Statistics 2025-09-11 Daniel Würzler Barreto , Mevin B. Hooten

In standardized educational testing, test items are reused in multiple test administrations. To ensure the validity of test scores, the psychometric properties of items should remain unchanged over time. In this paper, we consider the…

Applications · Statistics 2021-10-26 Yunxiao Chen , Yi-Hsuan Lee , Xiaoou Li

Test-time optimization remains impractical at scale due to prohibitive inference costs--techniques like iterative refinement and multi-step verification can require $10-100\times$ more compute per query than standard decoding. Latent space…

Machine Learning · Computer Science 2025-11-10 Nathan Egbuna , Saatvik Gaur , Sunishchal Dev , Ashwinee Panda , Maheep Chaudhary

Bayesian Decision Trees (DTs) are generally considered a more advanced and accurate model than a regular Decision Tree (DT) because they can handle complex and uncertain data. Existing work on Bayesian DTs uses Markov Chain Monte Carlo…

Machine Learning · Computer Science 2023-05-31 Efthyvoulos Drousiotis , Alexander M. Phillips , Paul G. Spirakis , Simon Maskell

Classifying sequential data as early and as accurately as possible is a challenging yet critical problem, especially when a sampling cost is high. One algorithm that achieves this goal is the sequential probability ratio test (SPRT), which…

Machine Learning · Computer Science 2021-02-09 Akinori F. Ebihara , Taiki Miyagawa , Kazuyuki Sakurai , Hitoshi Imaoka