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Gadolinium-based contrast agents (GBCAs) are widely used in magnetic resonance imaging (MRI) to enhance lesion detection and characterisation, particularly in the field of neuro-oncology. Nevertheless, concerns regarding gadolinium…

Image and Video Processing · Electrical Eng. & Systems 2025-10-03 Pierre Fayolle , Alexandre Bône , Noëlie Debs , Philippe Robert , Pascal Bourdon , Remy Guillevin , David Helbert

\textit{Objective:} Gadolinium-based contrast agents (GBCAs) have been widely used to better visualize disease in brain magnetic resonance imaging (MRI). However, gadolinium deposition within the brain and body has raised safety concerns…

Image and Video Processing · Electrical Eng. & Systems 2022-07-19 Chao Chen , Catalina Raymond , Bill Speier , Xinyu Jin , Timothy F. Cloughesy , Dieter Enzmann , Benjamin M. Ellingson , Corey W. Arnold

Recently, deep learning (DL)-based methods have been proposed for the computational reduction of gadolinium-based contrast agents (GBCAs) to mitigate adverse side effects while preserving diagnostic value. Currently, the two main challenges…

Focused ultrasound (FUS) can be used to open the blood-brain barrier (BBB), and MRI with contrast agents can detect that opening. However, repeated use of gadolinium-based contrast agents (GBCAs) presents safety concerns to patients. This…

Quantitative Methods · Quantitative Biology 2023-01-19 P. Lee , H. Wei , A. N. Pouliopoulos , B. T. Forsyth , Y. Yang , C. Zhang , A. F. Laine , E. E. Konofagou , C. Wu , J. Guo

Today Gadolinium-based contrast agents (GBCA) are indispensable in Magnetic Resonance Imaging (MRI) for diagnosing various diseases. However, GBCAs are expensive and may accumulate in patients with potential side effects, thus…

Image and Video Processing · Electrical Eng. & Systems 2023-06-27 Thomas Pinetz , Erich Kobler , Robert Haase , Katerina Deike-Hofmann , Alexander Radbruch , Alexander Effland

Deep learning (DL) based contrast dose reduction and elimination in MRI imaging is gaining traction, given the detrimental effects of Gadolinium-based Contrast Agents (GBCAs). These DL algorithms are however limited by the availability of…

Image and Video Processing · Electrical Eng. & Systems 2023-07-25 Dayang Wang , Srivathsa Pasumarthi , Greg Zaharchuk , Ryan Chamberlain

Contrast-enhanced magnetic resonance imaging (MRI) is pivotal in the pipeline of brain tumor segmentation and analysis. Gadolinium-based contrast agents, as the most commonly used contrast agents, are expensive and may have potential side…

Image and Video Processing · Electrical Eng. & Systems 2024-06-25 Lujun Gui , Chuyang Ye , Tianyi Yan

Magnetic resonance imaging (MRI) is the most sensitive technique for breast cancer detection among current clinical imaging modalities. Contrast-enhanced MRI (CE-MRI) provides superior differentiation between tumors and invaded healthy…

Image and Video Processing · Electrical Eng. & Systems 2023-07-04 Tianyu Zhang , Luyi Han , Anna D'Angelo , Xin Wang , Yuan Gao , Chunyao Lu , Jonas Teuwen , Regina Beets-Tan , Tao Tan , Ritse Mann

Contrast enhancement by Gadolinium-based contrast agents (GBCAs) is a vital tool for tumor diagnosis in neuroradiology. Based on brain MRI scans of glioblastoma before and after Gadolinium administration, we address enhancement prediction…

Image and Video Processing · Electrical Eng. & Systems 2024-10-14 Moritz Piening , Fabian Altekrüger , Gabriele Steidl , Elke Hattingen , Eike Steidl

Objectives:To develop a framework for obtaining dynamic susceptibility contrast magnetic resonance imaging (DSC-MRI) derived relative cerebral blood volume (rCBV) maps without gadolinium-based contrast agent (GBCA) injection. Methods:This…

Medical Physics · Physics 2023-08-29 Lu Wang , Zhen Xing , Congbo Cai , Zhong Chen , Dairong Cao , Shuhui Cai

Brain tumour imaging assessment typically requires both pre- and post-contrast MRI, but gadolinium administration is not always desirable, such as in frequent follow-up, renal impairment, allergy, or paediatric patients. We aimed to develop…

Brain atrophy is an important biomarker for monitoring neurodegeneration and disease progression in conditions such as multiple sclerosis (MS). An accurate and robust quantitative measurement of brain volume change is paramount for…

Quantitative Methods · Quantitative Biology 2023-02-09 Geng Zhan , Dongang Wang , Mariano Cabezas , Lei Bai , Kain Kyle , Wanli Ouyang , Michael Barnett , Chenyu Wang

Objective: Gadolinium-based contrast agents (GBCAs) are commonly used in MRI scans of patients with gliomas to enhance brain tumor characterization using T1-weighted (T1W) MRI. However, there is growing concern about GBCA toxicity. This…

Image and Video Processing · Electrical Eng. & Systems 2024-09-04 Zach Eidex , Mojtaba Safari , Richard L. J. Qiu , David S. Yu , Hui-Kuo Shu , Hui Mao , Xiaofeng Yang

Vascular remodelling is inherent to the pathogenesis of many diseases including cancer, neurodegeneration, fibrosis, hypertension, and diabetes. In this paper, a new susceptibility-contrast based MRI approach is established to analyse…

Gadolinium-based contrast agents (GBCAs) are central to glioma imaging but raise safety, cost, and accessibility concerns. Predicting contrast enhancement from non-contrast MRI using machine learning (ML) offers a safer alternative, as…

Computer Vision and Pattern Recognition · Computer Science 2025-09-16 Sajad Amiri , Shahram Taeb , Sara Gharibi , Setareh Dehghanfard , Somayeh Sadat Mehrnia , Mehrdad Oveisi , Ilker Hacihaliloglu , Arman Rahmim , Mohammad R. Salmanpour

Magnetic Resonance Imaging (MRI) is a vital modality for gaining precise anatomical information, and it plays a significant role in medical imaging for diagnosis and therapy planning. Image synthesis problems have seen a revolution in…

Image and Video Processing · Electrical Eng. & Systems 2024-04-16 Drici Mourad , Kazeem Oluwakemi Oseni

Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) plays an important role in diagnosis and grading of brain tumor. Although manual DCE biomarker extraction algorithms boost the diagnostic yield of DCE-MRI by providing…

Resolving arterial flows is essential for understanding cardiovascular pathologies, improving diagnosis, and monitoring patient condition. Ultrasound contrast imaging uses microbubbles to enhance the scattering of the blood pool, allowing…

With the increased need for multi-center magnetic resonance imaging studies, problems arise related to differences in hardware and software between centers. Namely, current algorithms for brain volume quantification are unreliable for the…

Image and Video Processing · Electrical Eng. & Systems 2019-11-12 Maria Ines Meyer , Ezequiel de la Rosa , Koen Van Leemput , Diana M. Sima

Reconstructing visual stimulus (image) only from human brain activity measured with functional Magnetic Resonance Imaging (fMRI) is a significant and meaningful task in Human-AI collaboration. However, the inconsistent distribution and…

Computer Vision and Pattern Recognition · Computer Science 2019-10-23 Ziqi Ren , Jie Li , Xuetong Xue , Xin Li , Fan Yang , Zhicheng Jiao , Xinbo Gao
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