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Related papers: OpenHI2 -- Open source histopathological image pla…

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Immunohistochemistry (IHC) biomarkers are essential tools for reliable cancer diagnosis and subtyping. It requires cross-staining comparison among Whole Slide Images (WSIs) of IHCs and hematoxylin and eosin (H&E) slides. Currently,…

Image and Video Processing · Electrical Eng. & Systems 2023-12-27 Abubakr Shafique , Morteza Babaie , Ricardo Gonzalez , Adrian Batten , Soma Sikdar , H. R. Tizhoosh

Breast cancer is the most common cancer among women worldwide. The human epidermal growth factor receptor 2 (HER2) with immunohistochemical (IHC) is widely used for pathological evaluation to provide the appropriate therapy for patients…

Quantitative Methods · Quantitative Biology 2022-03-08 Zichen Zhang , Lang Wang , Shuhao Wang

Histopathology serves as the gold standard in cancer diagnosis, with clinical reports being vital in interpreting and understanding this process, guiding cancer treatment and patient care. The automation of histopathology report generation…

Computer Vision and Pattern Recognition · Computer Science 2024-06-19 Zhengrui Guo , Jiabo Ma , Yingxue Xu , Yihui Wang , Liansheng Wang , Hao Chen

Pathology foundation models substantially advanced the possibilities in computational pathology -- yet tradeoffs in terms of performance, robustness, and computational requirements remained, which limited their clinical deployment. In this…

Digitized histopathology glass slides, known as Whole Slide Images (WSIs), are often several gigapixels large and contain sensitive metadata information, which makes distributed processing unfeasible. Moreover, artifacts in WSIs may result…

Computational Engineering, Finance, and Science · Computer Science 2023-09-14 Yuandou Wang , Neel Kanwal , Kjersti Engan , Chunming Rong , Zhiming Zhao

Biomedical challenges have become the de facto standard for benchmarking biomedical image analysis algorithms. While the number of challenges is steadily increasing, surprisingly little effort has been invested in ensuring high quality…

Computer Vision and Pattern Recognition · Computer Science 2019-12-06 Manuel Wiesenfarth , Annika Reinke , Bennett A. Landman , Manuel Jorge Cardoso , Lena Maier-Hein , Annette Kopp-Schneider

The need for fast diagnostic image viewing in zero footprint web applications and the ever increasing image sizes for new modalities such as digital pathology have painfully brought to light that the currently available image compression…

Image and Video Processing · Electrical Eng. & Systems 2020-05-19 Bas Hulsken

Tools, models and statistical methods for signal processing and medical image analysis and training deep learning models to create research prototypes for eventual clinical applications are of special interest to the biomedical imaging…

Image and Video Processing · Electrical Eng. & Systems 2023-12-22 Pratik Shah , Jenna Lester , Jana G Deflino , Vinay Pai

Microscopic interpretation of histopathology images underlies many important diagnostic and treatment decisions. While advances in vision-language modeling raise new opportunities for analysis of such images, the gigapixel-scale size of…

A modern digital pathology vendor-agnostic binary slide format specifically targeting the unmet need of efficient real-time transfer and display has not yet been established. The growing adoption of digital pathology only intensifies the…

Image and Video Processing · Electrical Eng. & Systems 2025-08-05 Ryan Erik Landvater , Michael David Olp , Mustafa Yousif , Ulysses Balis

Digital pathology and the integration of artificial intelligence (AI) models have revolutionized histopathology, opening new opportunities. With the increasing availability of Whole Slide Images (WSIs), there's a growing demand for…

Image and Video Processing · Electrical Eng. & Systems 2024-04-30 Areej Alsaafin , Peyman Nejat , Abubakr Shafique , Jibran Khan , Saghir Alfasly , Ghazal Alabtah , H. R. Tizhoosh

Breast cancer is a health problem that affects mainly the female population. An early detection increases the chances of effective treatment, improving the prognosis of the disease. In this regard, computational tools have been proposed to…

Computer Vision and Pattern Recognition · Computer Science 2022-03-01 Steve Tsham Mpinda Ataky , Alessandro Lameiras Koerich

The overexpression of human epidermal growth factor receptor 2 (HER2) has been established as a therapeutic target in multiple types of cancers, such as breast and gastric cancers. Immunohistochemistry (IHC) is employed as a basic HER2 test…

Image and Video Processing · Electrical Eng. & Systems 2020-09-16 Jun Zhang , Kuan Tian , Pei Dong , Haocheng Shen , Kezhou Yan , Jianhua Yao , Junzhou Huang , Xiao Han

Artificial intelligence has started to transform histopathology impacting clinical diagnostics and biomedical research. However, while many computational pathology approaches have been proposed, most current AI models are limited with…

Pathology image analysis plays a pivotal role in medical diagnosis, with deep learning techniques significantly advancing diagnostic accuracy and research. While numerous studies have been conducted to address specific pathological tasks,…

Image and Video Processing · Electrical Eng. & Systems 2025-03-31 Dankai Liao , Sicheng Chen , Nuwa Xi , Qiaochu Xue , Jieyu Li , Lingxuan Hou , Zeyu Liu , Chang Han Low , Yufeng Wu , Yiling Liu , Yanqin Jiang , Dandan Li , Shangqing Lyu

The development of robust artificial intelligence models for histopathology diagnosis is severely constrained by the scarcity of expert-annotated lesion data, particularly for rare pathologies and underrepresented disease subtypes. While…

Computer Vision and Pattern Recognition · Computer Science 2026-01-14 Mohamad Koohi-Moghadam , Mohammad-Ali Nikouei Mahani , Kyongtae Tyler Bae

Application of deep learning on histopathological whole slide images (WSIs) holds promise of improving diagnostic efficiency and reproducibility but is largely dependent on the ability to write computer code or purchase commercial…

Virtual staining has emerged as a powerful alternative to traditional histopathological staining techniques, enabling rapid, reagent-free image transformations. However, existing evaluation methods predominantly rely on full-reference image…

Image and Video Processing · Electrical Eng. & Systems 2025-07-18 Qiankai Wang , James E. D. Tweel , Parsin Haji Reza , Anita Layton

Photoacoustic (PA) imaging systems based on clinical linear ultrasound arrays have become increasingly popular in translational PA research. Such systems can be more easily integrated in a clinical workflow due to the simultaneous access to…

We present a novel diffusion-based approach to generate synthetic histopathological Whole Slide Images (WSIs) at an unprecedented gigapixel scale. Synthetic WSIs have many potential applications: They can augment training datasets to…

Image and Video Processing · Electrical Eng. & Systems 2023-11-15 Robert Harb , Thomas Pock , Heimo Müller