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We propose a continuous-time formulation of persistent contrastive divergence (PCD) for maximum likelihood estimation (MLE) of unnormalised densities. Our approach expresses PCD as a coupled, multiscale system of stochastic differential…

Machine Learning · Statistics 2025-10-03 Paul Felix Valsecchi Oliva , O. Deniz Akyildiz , Andrew Duncan

Artificial intelligence (AI) techniques are widely applied in the life sciences. However, applying innovative AI techniques to understand and deconvolute biological complexity is hindered by the learning curve for life science scientists to…

Artificial Intelligence · Computer Science 2024-03-28 Nisha Pillai , Athish Ram Das , Moses Ayoola , Ganga Gireesan , Bindu Nanduri , Mahalingam Ramkumar

The emergence of Large Code Models (LCMs) has transformed software engineering (SE) automation, driving significant advancements in tasks such as code generation, source code documentation, code review, and bug fixing. However, these…

Software Engineering · Computer Science 2025-05-06 Antonio Mastropaolo , Denys Poshyvanyk

The intersection of physics and machine learning has given rise to the physics-enhanced machine learning (PEML) paradigm, aiming to improve the capabilities and reduce the individual shortcomings of data- or physics-only methods. In this…

Machine Learning · Computer Science 2024-04-23 Marcus Haywood-Alexander , Wei Liu , Kiran Bacsa , Zhilu Lai , Eleni Chatzi

Stochastic differential equations (SDEs) are popular tools to analyse time series data in many areas, such as mathematical finance, physics, and biology. They provide a mechanistic description of the phenomeon of interest, and their…

Methodology · Statistics 2021-02-01 Théo Michelot , Richard Glennie , Catriona Harris , Len Thomas

Classification and segmentation are crucial in medical image analysis as they enable accurate diagnosis and disease monitoring. However, current methods often prioritize the mutual learning features and shared model parameters, while…

Computer Vision and Pattern Recognition · Computer Science 2023-08-03 Kai Ren , Ke Zou , Xianjie Liu , Yidi Chen , Xuedong Yuan , Xiaojing Shen , Meng Wang , Huazhu Fu

Unified models (UMs) hold promise for their ability to understand and generate content across heterogeneous modalities. Compared to merely generating visual content, the use of UMs for interleaved cross-modal reasoning is more promising and…

Computer Vision and Pattern Recognition · Computer Science 2026-04-03 Jiachun Jin , Zetong Zhou , Xiao Yang , Hao Zhang , Pengfei Liu , Jun Zhu , Zhijie Deng

Constructing scientific multimodal document reasoning datasets for foundation model training involves an inherent trade-off among scale, faithfulness, and realism. To address this challenge, we introduce the synthesize-and-reground…

Computation and Language · Computer Science 2026-04-30 Ziyu Chen , Yilun Zhao , Chengye Wang , Rilyn Han , Manasi Patwardhan , Arman Cohan

With the explosion of applications of Data Science, the field is has come loose from its foundations. This article argues for a new program of applied research in areas familiar to researchers in Bayesian methods in AI that are needed to…

Machine Learning · Computer Science 2023-07-04 John Mark Agosta , Robert Horton

Quantum computing promises to speed up some of the most challenging problems in science and engineering. Quantum algorithms have been proposed showing theoretical advantages in applications ranging from chemistry to logistics optimization.…

Quantum Physics · Physics 2021-11-12 Niklas Heim , Atiyo Ghosh , Oleksandr Kyriienko , Vincent E. Elfving

Fast and accurate simulation of dynamical systems is a fundamental challenge across scientific and engineering domains. Traditional numerical integrators often face a trade-off between accuracy and computational efficiency, while existing…

Computational Engineering, Finance, and Science · Computer Science 2026-03-06 Jiaxin Yuan , Haizhao Yang , Maria Cameron

We use deep learning to model interactions across two or more sets of objects, such as user-movie ratings, protein-drug bindings, or ternary user-item-tag interactions. The canonical representation of such interactions is a matrix (or a…

Machine Learning · Statistics 2018-06-12 Jason Hartford , Devon R Graham , Kevin Leyton-Brown , Siamak Ravanbakhsh

Conceptual models as representations of real-world systems are based on diverse techniques in various disciplines but lack a framework that provides multidisciplinary ontological understanding of real-world phenomena. Concurrently, systems…

Software Engineering · Computer Science 2023-06-27 Sabah Al-Fedaghi

Intelligent learning diagnosis is a critical engine of intelligent tutoring systems, which aims to estimate learners' current knowledge mastery status and predict their future learning performance. The significant challenge with traditional…

Artificial Intelligence · Computer Science 2023-06-14 Zhifeng Wang , Wenxing Yan , Chunyan Zeng , Shi Dong

Designing safe and sustainable chemicals is critical to combat chemical pollution in our environment. Machine learning (ML) methods have been developed to aid with de novo molecule design. However, data on the environmental impacts of…

Human-Computer Interaction · Computer Science 2026-05-18 Coelina Robinson , Franziska Weissbach , Kjell Jorner , Mennatallah El-Assady , Christina Humer

Nonlinear models and optimization methods have successfully tackled a rapidly growing set of problems in recent years. Indeed, a relatively small toolbox of such models and methods can provide sufficient performance across a large landscape…

Optimization and Control · Mathematics 2026-05-01 Akshunna S. Dogra

Predictive simulations of complex systems are essential for applications ranging from weather forecasting to drug design. The veracity of these predictions hinges on their capacity to capture the effective system dynamics. Massively…

Computational Physics · Physics 2021-10-20 Pantelis R. Vlachas , Georgios Arampatzis , Caroline Uhler , Petros Koumoutsakos

Partial differential equations (PDEs) govern a wide range of physical systems, but solving them efficiently remains a major challenge. The idea of a scientific foundation model (SciFM) is emerging as a promising tool for learning…

Machine Learning · Computer Science 2025-03-26 Amin Totounferoush , Serge Kotchourko , Michael W. Mahoney , Steffen Staab

Causal inference in observational panel data has become a central concern in economics,policy analysis,and the broader social sciences.To address the core contradiction where traditional difference-in-differences (DID) struggles with…

Machine Learning · Statistics 2025-07-23 Yile Yu , Anzhi Xu , Yi Wang

A diffusion probabilistic model (DPM) is a generative model renowned for its ability to produce high-quality outputs in tasks such as image and audio generation. However, training DPMs on large, high-dimensional datasets such as…

Quantum Physics · Physics 2025-11-05 Yunfei Wang , Ruoxi Jiang , Yingda Fan , Xiaowei Jia , Jens Eisert , Junyu Liu , Jin-Peng Liu