Related papers: A 100 ps TOF Detection System for On-Line Range- M…
In order to fully exploit the ballistic potential of particle therapy, we propose an online range monitoring concept based on high-resolution Time-Of-Flight (TOF)-resolved Prompt Gamma (PG) detection in a single proton counting regime. In a…
We are currently conceiving, through (MC) simulation, a multi-channel gamma detector array (TIARA for Time-of-flight Imaging ARrAy) for the online monitoring of protontherapy treatments. By measuring the Time-Of-Flight (TOF) between a beam…
We recently proposed a new approach for the real-time monitoring of particle therapy treatments with the goal of achieving high sensitivities on the particle range measurement already at limited counting statistics. This method extends the…
A beam tagging hodoscope prototype made of squared 1 mm$^2$ fibers arranged in two perpendicular planes and coupled to multi-anode photomultipliers has been studied using 65 MeV proton as well as 95 MeV/u $^{12}$C beams at various…
The major advantage of proton therapy over conventional radiotherapy is the dose deposition pattern, enabling precise coverage of the tumour volume while sparing nearby healthy tissues. However, accurate control of the proton beam range…
Fast procedures for the beam quality assessment and for the monitoring of beam energy modulations during the irradiation are among the most urgent improvements in particle therapy. Indeed, the online measurement of the particle beam energy…
In the context of online ion range verification in particle therapy, the CLaRyS collaboration is developing Prompt-Gamma (PG) detection systems. The originality in the CLaRyS approach is to use a beam-tagging hodoscope in coincidence with…
In the context of range monitoring for particle therapy, this study presents the first experimental results obtained with the TIARA detector using carbon-ion beams at the CNAO clinical center in Pavia, Italy. TIARA is based on the Prompt…
Intraoperative Gamma Probe (IPG) remains the current gold standard modality for sentinel lymph node identification and tumor removal in cancer patients. However, even alongside the optical dyes they do not meet with <5% false negative rates…
We developed a novel gamma-ray detection system (TIARA) for range monitoring in Particle Therapy. The system employs Cherenkov-based gamma-ray detection modules arranged around the target or patient, operated in time coincidence with a fast…
This paper describes the use of the time-of-flight (TOF) technique as a particle identification method for the HERMES experiment. The time-of-flight is measured by two 1x4 m^2 scintillation hodoscopes that initially were designed for the…
PET imaging is a non-invasive technique for particle range verification in proton therapy. It is based on measuring the beta+ annihilations caused by nuclear interactions of the protons in the patient. In this work we present measurements…
Proton therapy's full potential is limited by uncertainties that prevent optimal dose distribution. Monitoring techniques can reduce these uncertainties and enable adaptive treatment planning. Spatiotemporal Emission Reconstruction from…
In this paper we prove that the choice of a suitable treatment of the scintillator surfaces, along with suitable photodetectors electronics and specific algorithms for raw data analysis, allow to achieve an optimal tradeoff between energy,…
Range uncertainties in proton therapy hamper treatment precision. Prompt gamma-rays were suggested 16 years ago for real-time range verification, and have already shown promising results in clinical studies with collimated cameras.…
TORCH is a large-area, high-precision time-of-flight (ToF) detector designed to provide charged-particle identification in the 2-20 GeV$/c$ momentum range. Prompt Cherenkov photons emitted by charged hadrons as they traverse a 10mm quartz…
Uncertainties in the proton range in tissue during proton therapy limit the precision in treatment delivery. These uncertainties result in expanded treatment margins, thereby increasing radiation dose to healthy tissue. Real-time range…
Coincidence time resolution (CTR) in time-of-flight positron emission tomography (TOF-PET) has significantly improved with advancements in scintillators, photodetectors, and readout electronics. Achieving a CTR of 100 ps remains challenging…
We introduce pulsed correlation time-of-flight (PC-ToF) sensing, a new operation mode for correlation time-of-flight range sensors that combines a sub-nanosecond laser pulse source with a rectangular demodulation at the sensor side. In…
Objective. Prompt-gamma imaging encompasses several approaches for online monitoring of beam range or deposited dose distribution in proton therapy. We test one of the imaging techniques - a coded mask approach - both experimentally and via…