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Improved understanding of charge-transport in single molecules is essential for harnessing the potential of molecules e.g. as circuit components at the ultimate size limit. However, interpretation and analysis of the large, stochastic…

Mesoscale and Nanoscale Physics · Physics 2020-08-06 Nathan D. Bamberger , Jeffrey A. Ivie , Keshaba N. Parida , Dominic V. McGrath , Oliver L. A. Monti

Datasets from single-molecule experiments often reflect a large variety of molecular behaviour. The exploration of such datasets can be challenging, especially if knowledge about the data is limited and a priori assumptions about expected…

Data Analysis, Statistics and Probability · Physics 2020-04-06 Anton Vladyka , Tim Albrecht

We explore the merits of neural network boosted, principal-component-projection-based, unsupervised data classification in single-molecule break junction measurements, demonstrating that this method identifies highly relevant trace classes…

Mesoscale and Nanoscale Physics · Physics 2023-03-10 Zoltán Balogh , Gréta Mezei , Nóra Tenk , András Magyarkuti , András Halbritter

A simple and fast analysis method to sort large data sets into groups with shared distinguishing characteristics is described, and applied to single molecular break junction conductance versus electrode displacement data. The method, based…

Mesoscale and Nanoscale Physics · Physics 2018-01-10 J. M. Hamill , X. T. Zhao , G. Mészáros , M. R. Bryce , M. Arenz

Most single-molecule transport experiments produce large and stochastic datasets containing a wide range of behaviors, presenting both a challenge to their analysis, but also an opportunity for discovering new physical insights. Recently,…

Mesoscale and Nanoscale Physics · Physics 2021-08-19 Nathan D. Bamberger , Dylan Dyer , Keshaba N. Parida , Dominic V. McGrath , Oliver L. A. Monti

Structural breaks occur in timeseries data across a broad range of fields, from economics to nanosciences. For measurements of single-molecule break junctions, structural breaks in conductance versus displacement data occur when the…

Few-shot learning is a promising approach to molecular property prediction as supervised data is often very limited. However, many important molecular properties depend on complex molecular characteristics -- such as the various 3D…

Machine Learning · Computer Science 2023-10-10 Christopher Fifty , Joseph M. Paggi , Ehsan Amid , Jure Leskovec , Ron Dror

We present an original method to estimate the conductivity of a single molecule anchored to nanometric-sized metallic electrodes, using a Mechanically Controlled Break Junction (MCBJ) operated at room temperature in liquid. We record the…

Mesoscale and Nanoscale Physics · Physics 2018-03-16 M. Gil , T. Malinowski , M. Iazykov , H. Klein

At the extreme energies of the Large Hadron Collider, massive particles can be produced at such high velocities that their hadronic decays are collimated and the resulting jets overlap. Deducing whether the substructure of an observed jet…

High Energy Physics - Experiment · Physics 2016-06-01 Pierre Baldi , Kevin Bauer , Clara Eng , Peter Sadowski , Daniel Whiteson

Accurately predicting molecular properties is a challenging but essential task in drug discovery. Recently, many mono-modal deep learning methods have been successfully applied to molecular property prediction. However, the inherent…

Machine Learning · Computer Science 2024-09-16 Xiaohua Lu , Liangxu Xie , Lei Xu , Rongzhi Mao , Shan Chang , Xiaojun Xu

We propose an objective and robust method to extract the electrical conductance of single molecules connected to metal electrodes from a set of measured conductance data. Our method roots in the physics of tunneling and is tested on…

Mesoscale and Nanoscale Physics · Physics 2007-05-23 M. Teresa González , Songmei Wu , Roman Huber , Sense J. van der Molen , Christian Schönenberger , Michel Calame

This article proposes a novel unsupervised learning framework for detecting the number of tunnel junctions in subterranean environments based on acquired 2D point clouds. The implementation of the framework provides valuable information for…

Graph neural networks (GNNs) demonstrate great performance in compound property and activity prediction due to their capability to efficiently learn complex molecular graph structures. However, two main limitations persist including…

Biomolecules · Quantitative Biology 2023-10-10 Apakorn Kengkanna , Masahito Ohue

We propose a construction for joint feature learning and clustering of multichannel extracellular electrophysiological data across multiple recording periods for action potential detection and discrimination ("spike sorting"). Our…

Feature extraction - the ability to identify relevant properties of data - is a key factor underlying the success of deep learning. Yet, it has proved difficult to elucidate its nature within existing predictive theories, to the extent that…

Disordered Systems and Neural Networks · Physics 2025-08-29 Andrea Corti , Rosalba Pacelli , Pietro Rotondo , Marco Gherardi

Unsupervised machine learning methods can be of great help in many traditional engineering disciplines, where huge amount of labeled data is not readily available or is extremely difficult or costly to generate. Two specific examples…

Machine Learning · Computer Science 2020-07-21 Raj Kishore , Zohar Nussinov , Kisor Kumar Sahu

Electronic transport properties for single-molecule junctions have been widely measured by several techniques, including mechanically controllable break junctions, electromigration break junctions or by means of scanning tunneling…

Mesoscale and Nanoscale Physics · Physics 2020-07-22 Ferdinand Evers , Richard Korytár , Sumit Tewari , Jan M. van Ruitenbeek

Unsupervised learning methods for feature extraction are becoming more and more popular. We combine the popular contrastive learning method (prototypical contrastive learning) and the classic representation learning method (autoencoder) to…

Computer Vision and Pattern Recognition · Computer Science 2022-05-11 Zeyu Cao , Xiaorun Li , Liaoying Zhao

We report a method using scanning tunnelling microscope single molecular break junction to simultaneously measure and correlate the single-molecule thermopower and electrical conductance. In contrast to previously reported approaches, it…

Mesoscale and Nanoscale Physics · Physics 2021-09-24 Joseph M. Hamill , Christopher Weaver , Tim Albrecht

Data classification techniques partition the data or feature space into smaller sub-spaces, each corresponding to a specific class. To classify into subspaces, physical features e.g., distance and distributions are utilized. This approach…

Machine Learning · Computer Science 2025-03-11 Josimar Chire , Khalid Mahmood , Zhao Liang
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