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Modeling the time-series of high-dimensional, longitudinal data is important for predicting patient disease progression. However, existing neural network based approaches that learn representations of patient state, while very flexible, are…

Machine Learning · Computer Science 2021-06-21 Zeshan Hussain , Rahul G. Krishnan , David Sontag

Data-dependent metrics are powerful tools for learning the underlying structure of high-dimensional data. This article develops and analyzes a data-dependent metric known as diffusion state distance (DSD), which compares points using a…

Machine Learning · Statistics 2020-03-10 Lenore Cowen , Kapil Devkota , Xiaozhe Hu , James M. Murphy , Kaiyi Wu

Clinical outcome or severity prediction from medical images has largely focused on learning representations from single-timepoint or snapshot scans. It has been shown that disease progression can be better characterized by temporal imaging.…

Image and Video Processing · Electrical Eng. & Systems 2022-04-01 Aishik Konwer , Xuan Xu , Joseph Bae , Chao Chen , Prateek Prasanna

Sequences of events including infectious disease outbreaks, social network activities, and crimes are ubiquitous and the data on such events carry essential information about the underlying diffusion processes between communities (e.g.,…

Social and Information Networks · Computer Science 2021-06-08 Maya Okawa , Tomoharu Iwata , Yusuke Tanaka , Hiroyuki Toda , Takeshi Kurashima , Hisashi Kashima

Despite the central role of sensor-derived measurements such as imaging traits and plasma biomarkers in biomedical research and clinical practice, existing generative models for disease prediction largely depend on event-level…

Artificial Intelligence · Computer Science 2026-05-12 Ziquan Wei , Tingting Dan , Guorong Wu

It is essential to understand the complex structure of the human brain to develop new treatment approaches for neurodegenerative disorders (NDDs). This review paper comprehensively discusses the challenges associated with modelling the…

Neurons and Cognition · Quantitative Biology 2024-11-01 Hina Shaheen , Roderick Melnik

Graph models are widely used to analyse diffusion processes embedded in social contacts and to develop applications. A range of graph models are available to replicate the underlying social structures and dynamics realistically. However,…

Social and Information Networks · Computer Science 2018-07-27 Md Shahzamal , Raja Jurdak , Bernard Mans , Frank de Hoog

To better predict the dynamics of epidemics such as COVID-19, it is important not only to investigate the network of local and long-range contagious contacts but also to understand the temporal dynamics of infectiousness and detectable…

Populations and Evolution · Quantitative Biology 2025-09-03 Miguel A. Cajahuanca Ricaldi , Yaroslav Ispolatov

Temporal Point Processes (TPP) play an important role in predicting or forecasting events. Although these problems have been studied extensively, predicting multiple simultaneously occurring events can be challenging. For instance, more…

Machine Learning · Computer Science 2023-10-02 Parag Dutta , Kawin Mayilvaghanan , Pratyaksha Sinha , Ambedkar Dukkipati

To infer a diffusion network based on observations from historical diffusion processes, existing approaches assume that observation data contain exact occurrence time of each node infection, or at least the eventual infection statuses of…

Social and Information Networks · Computer Science 2023-12-14 Hao Huang , Qian Yan , Keqi Han , Ting Gan , Jiawei Jiang , Quanqing Xu , Chuanhui Yan

Comorbidity networks, which capture disease-disease co-occurrence usually based on electronic health records, reveal structured patterns in how diseases cluster and progress across individuals. However, how these networks evolve across…

The spread of viruses in biological networks, computer networks, and human contact networks can have devastating effects; developing and analyzing mathematical models of these systems can be insightful and lead to societal benefits. Prior…

Optimization and Control · Mathematics 2016-09-19 Philip E. Paré , Angelia Nedić , Carolyn L. Beck

Motivation: Several different threads of research have been proposed for modeling and mining temporal data. On the one hand, approaches such as dynamic Bayesian networks (DBNs) provide a formal probabilistic basis to model relationships…

Machine Learning · Computer Science 2009-04-15 Debprakash Patnaik , Srivatsan Laxman , Naren Ramakrishnan

The exploration of epidemic dynamics on dynamically evolving ("adaptive") networks poses nontrivial challenges to the modeler, such as the determination of a small number of informative statistics of the detailed network state (that is, a…

Quantitative Methods · Quantitative Biology 2015-07-07 Assimakis A. Kattis , Alexander Holiday , Ana-Andreea Stoica , Ioannis G. Kevrekidis

Many complex systems combine dense background structure with sparse contextual information. We introduce a diffusion-based framework for analyzing how sparse condition-specific layers reshape diffusion geometry in multilayer hypergraphs.…

Physics and Society · Physics 2026-05-21 Hao Ding , Sanjukta Krishnagopal

Alzheimer's disease (AD) is known as one of the major causes of dementia and is characterized by slow progression over several years, with no treatments or available medicines. In this regard, there have been efforts to identify the risk of…

Computer Vision and Pattern Recognition · Computer Science 2020-08-28 Wonsik Jung , Eunji Jun , Heung-Il Suk

Time-limited states characterise many dynamical processes on networks: disease infected individuals recover after some time, people forget news spreading on social networks, or passengers may not wait forever for a connection. These…

Physics and Society · Physics 2023-06-13 Arash Badie-Modiri , Márton Karsai , Mikko Kivelä

We study the temporal reconstruction of epidemics evolving over networks. Given partial or aggregated temporal information of the epidemic, our goal is to estimate the complete evolution of the spread leveraging the topology of the network…

Signal Processing · Electrical Eng. & Systems 2020-11-20 Gojko Cutura , Boning Li , Ananthram Swami , Santiago Segarra

The availability of a large amount of electronic health records (EHR) provides huge opportunities to improve health care service by mining these data. One important application is clinical endpoint prediction, which aims to predict whether…

Artificial Intelligence · Computer Science 2018-11-20 Luchen Liu , Jianhao Shen , Ming Zhang , Zichang Wang , Jian Tang

The spread of infectious diseases crucially depends on the pattern of contacts among individuals. Knowledge of these patterns is thus essential to inform models and computational efforts. Few empirical studies are however available that…