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Autocatalysis is thought to have played an important role in the earliest stages of the origin of life. An autocatalytic cycle (AC) is a set of reactions that results in stoichiometric increase in its constituent chemicals. When the…

Populations and Evolution · Quantitative Biology 2024-07-29 Alex M. Plum , Christopher P. Kempes , Zhen Peng , David A. Baum

Evolution produces complex and structured networks of interacting components in chemical, biological, and social systems. We describe a simple mathematical model for the evolution of an idealized chemical system to study how a network of…

Adaptation and Self-Organizing Systems · Physics 2014-03-05 Sanjay Jain , Sandeep Krishna

In this thesis we present a mathematical model describing the population dynamics of molecules in an artificial chemistry where large molecules can be produced by successive ligation of pairs of smaller molecules. The chemistry contains a…

Adaptation and Self-Organizing Systems · Physics 2013-04-03 Varun Giri

We present a benchmark study of autonomous, chemical agents exhibiting associative learning of an environmental feature. Associative learning has been widely studied in cognitive science and artificial intelligence, but are most commonly…

Adaptation and Self-Organizing Systems · Physics 2022-10-12 Stuart Bartlett , David Louapre

Autocatalytic Sets are reaction networks theorised as networks at the basis of life. Their main feature is the ability of spontaneously emerging and self-reproducing. The Reflexively and Food-generated theory provides a formal definition of…

Molecular Networks · Quantitative Biology 2020-10-19 Alessandro Ravoni

An autocatalytic pattern matching polymer system is studied as an abstract model for chemical ecosystem evolution. Highly ordered populations with particular sequence patterns appear spontaneously out of a vast number of possible states.…

Molecular Networks · Quantitative Biology 2015-06-17 Shinpei Tanaka , Harold Fellermann , Steen Rasmussen

Chemical kinetics plays an important role in governing the thermal evolution in reactive flows problems. The possible interactions between chemical species increase drastically with the number of species considered in the system. Various…

Instrumentation and Methods for Astrophysics · Physics 2022-07-18 Kwok Sun Tang , Matthew Turk

We study a family of networks of autocatalytic reactions, which we call hyperchains, that are a generalization of hypercycles. Hyperchains, and the associated dynamical system called replicator equations, are a possible mechanism for…

Dynamical Systems · Mathematics 2021-04-23 Badal Joshi , Gheorghe Craciun

To unveil the logic of cell from a level of chemical reaction dynamics, we need to clarify how ensemble of chemicals can autonomously produce the set of chemical, without assuming a specific external control echanism. A cell consists of a…

Molecular Networks · Quantitative Biology 2007-05-23 Kunihiko Kaneko

Many examples of cooperation exist in biology. In chemical systems however, which can sometimes be quite complex, we do not appear to observe intricate cooperative interactions. A key question for the origin of life, is then how can…

Populations and Evolution · Quantitative Biology 2018-02-23 Omer Markovitch , Olaf Witkowski , Nathaniel Virgo

We analyze a model of interacting agents (e.g. prebiotic chemical species) which are represended by nodes of a network, whereas their interactions are mapped onto directed links between these nodes. On a fast time scale, each agent follows…

Populations and Evolution · Quantitative Biology 2009-11-13 Adrian M. Seufert , Frank Schweitzer

Explaining the origin of life requires us to explain how self-replication arises. To be specific, how can a self-replicating entity develop spontaneously from a chemical reaction system in which no reaction is self-replicating? Previously…

Adaptation and Self-Organizing Systems · Physics 2020-12-18 Yu Liu , David Sumpter

Life can be viewed as a localized chemical system that sits on, or in the basin of attraction of, a metastable dynamical attractor state that remains out of equilibrium with the environment. Such a view of life allows that new living states…

Populations and Evolution · Quantitative Biology 2018-01-08 David A. Baum

Life is commonly described as a self-organized, far-from-equilibrium process that maintains internal order by consuming free energy and exporting entropy. This thermodynamic view underlies diverse theoretical frameworks -- from autopoiesis…

Biological Physics · Physics 2025-12-23 Didier Sornette , Virgile Troude

An important transition after the origin of life was the first emergence of a Darwinian population, self-reproducing entities exhibiting differential reproduction, phenotypic variation, and inheritance of phenotypic traits. The simplest…

Biological Physics · Physics 2022-11-08 Yoshiya J. Matsubara , Sandeep Ameta , Shashi Thutupalli , Philippe Nghe , Sandeep Krishna

We investigate the properties of large random conservative chemical reaction networks composed of elementary reactions endowed with either mass-action or saturating kinetics, assigning kinetic parameters in a thermodynamically-consistent…

Molecular Networks · Quantitative Biology 2014-11-26 Erwan Bigan , Jean-Marc Steyaert , Stéphane Douady

Over the last years, analyses performed on a stochastic model of catalytic reaction networks have provided some indications about the reasons why wet-lab experiments hardly ever comply with the phase transition typically predicted by…

Computational Engineering, Finance, and Science · Computer Science 2013-10-01 Chiara Damiani , Alessandro Filisetti , Alex Graudenzi , Marco Villani , Roberto Serra

The ability of a chemical reaction network to generate itself by catalyzed reactions from constantly present environmental food sources is considered a fundamental property in origin-of-life research. Based on Kaufmann's autocatalytic sets,…

Molecular Networks · Quantitative Biology 2023-08-16 Dimitri Loutchko

The emergence of self-sustaining autocatalytic networks in chemical reaction systems has been studied as a possible mechanism for modelling how living systems first arose. It has been known for several decades that such networks will form…

Molecular Networks · Quantitative Biology 2020-11-24 Stuart Kauffman , Mike Steel

Ecology and evolution are inseparable. Motivated by some recent experiments, we have developed models of evolutionary ecology from the perspective of dynamic networks. In these models, in addition to the intra-node dynamics, which…

Populations and Evolution · Quantitative Biology 2009-11-10 Debashish Chowdhury , Dietrich Stauffer
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