Related papers: A DNA damage multi-scale model for NTCP in proton …
We propose an inclusive approach for calculating characteristics of secondary electrons produced by ions/protons in tissue-like media. This approach is based on an analysis of the projectile's interaction with the medium on the microscopic…
Nasopharyngeal Carcinoma (NPC) is endemic cancer in the south-east Asia. With the advent of intensity-modulated radiotherapy excellent locoregional control are being achieved. Consequently, this had led to pretreatment clinical staging…
Accurate dose calculation is vitally important for proton therapy. Pencil beam (PB) model-based dose calculation is fast but inaccurate due to the approximation when dealing with inhomogeneities. Monte Carlo (MC) dose calculation is the…
Acute lymphoblastic leukemia is the most common malignancy in childhood. Successful treatment requires initial high-intensity chemotherapy, followed by low-intensity oral maintenance therapy with oral 6-mercaptopurine (6MP) and methotrexate…
We present a theoretical agent-based model of cell evolution under the action of cytotoxic treatments, such as radioteraphy or chemoteraphy. The major features of cell cycle and proliferation, cell damage and repair, and chemical diffusion…
We present a first determination of the nuclear parton distribution functions (nPDF) based on the NNPDF methodology: nNNPDF1.0. This analysis is based on neutral-current deep-inelastic structure function data and is performed up to NNLO in…
Pancreatic cancer with more than 60,000 new cases each year has less than 10 percent 5-year overall survival. Radiation therapy (RT) is an effective treatment for Locally advanced pancreatic cancer (LAPC). The current clinical RT workflow…
Objective: This study aims to investigate the influence of organ architecture (specifically the distinction between serial and parallel tissue) on the protective FLASH effect when organs are irradiated with inhomogeneous dose distributions.…
To enable an exploration of the initiation mechanism of nanosecond laser damage on a potassium dihydrogen phosphate (KDP) surface, a defect-assisted energy deposition model is developed that involves light intensity enhancement and a…
As depth increases, linear energy transfer (LET) rises toward the distal edge of the Bragg peak, boosting the radiobiological effectiveness (RBE). To manage the biological variation and limit normal-tissue damage, LET-modifying objective…
Physicochemically informed biological sequence generation has the potential to accelerate computer-aided cellular therapy, yet current models fail to \emph{jointly} ensure novelty, diversity, and biophysical plausibility when designing…
Radiation Therapy (XRT) is one of the most common cancer treatment methods. In this paper, a new mathematical model is proposed for the population dynamics of heterogeneous tumor cells following external beam radiation treatment. According…
AI-assisted imaging made substantial advances in tumor diagnosis and management. However, a major barrier to developing robust oncology foundation models is the scarcity of large-scale, high-quality annotated datasets, which are limited by…
In carbon-therapy, the interaction of the incoming beam with human tissues may lead to the production of a large amount of nuclear fragments and secondary light particles. An accurate estimation of the biological dose deposited into the…
Purpose: Radiotherapy commonly relies on CT, but there is growing interest in using hybrid PET/MR. Therefore, dedicated hardware setups have been proposed for PET/MR systems which enable imaging in radiotherapy treatment position. These…
Dose reduction in computed tomography (CT) is essential for decreasing radiation risk in clinical applications. Iterative reconstruction is one of the most promising ways to compensate for the increased noise due to reduction of photon…
Treatment with high energy ionizing radiation is one of the main methods in modern cancer therapy that is in clinical use. During the last decades, two main approaches to dose calculation were used, Monte Carlo simulations and…
Low-dose computed tomography (LDCT) is an important topic in the field of radiology over the past decades. LDCT reduces ionizing radiation-induced patient health risks but it also results in a low signal-to-noise ratio (SNR) and a potential…
The failure of heterogeneous materials with microstructures is a complex process of damage nucleation, growth and localisation. This process spans multiple length scales and is challenging to simulate numerically due to its high…
Diffuse low grade gliomas are slowly growing tumors that always recur after treatment. In this paper, we revisit the modeling of the tumor radius evolution before and after the radiotherapy process and propose a novel model that is simple,…